Results 41 to 50 of about 355,907 (356)

TRPM8 levels determine tumor vulnerability to channel agonists

Molecular Oncology, EarlyView.
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo, Francesco Giuseppe Carbone, Kristi Buzo, Nicole Annesi, Sacha Genovesi, Annalisa Lorenzato, Karen Widmann, Michela Libergoli, Elisa Marmocchi, Giovanni Bertalot, Alberto Brolese, Mauro Giulio Papotti, Luca Molinaro, Orazio Caffo, Mattia Barbareschi, Alberto Bardelli, Alessandro Romanel, Sabrina Arena, Andrea Lunardi   +18 more
wiley   +1 more source

Therapeutic applications of a novel humanized monoclonal antibody targeting chemokine receptor CCR9 in pancreatic cancer

Molecular Oncology, EarlyView.
C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald, Anna M. Reagan, Charles J. Bailey, Mei Gao, Muqiang Gao, Angelica L. Solomon, Michael J. Cavnar, Prakash K. Pandalai, Mautin T. Barry‐Hundeyin, Megan M. Harper, Justin A. Rueckert, Ángela Turrero, Araceli Tobio, Anxo Vidal, Daniel Roca‐Lema, Elia Álvarez‐Coiradas, Pablo Garrido, Laureano Simón, Joseph Kim   +18 more
wiley   +1 more source

Thoracic duct drainage in organ transplantation: Will it permit better immunosuppression? [PDF]

, 1979
It is possible that thoracic-duct drainage, a major but neglected immunosuppressive adjunct, can have an important impact on organ transplantation.
Franks, JJ, Halgrimson, CG, Koep, LJ, Starzl, TE, Weil, R   +4 more
core  

Different behaviour of BK-virus infection in liver transplant recipients [PDF]

, 2016
Polyomavirus BK (BKV) infects up to 90% of the general population. After primary infection, occurring early during childhood, a state of non-replicative infection is established in the reno-urinary tract, without complications for immunocompetent hosts ...
MITTERHOFER, Anna Paola, Muiesan, Paolo, TINTI, FRANCESCA, UMBRO, ILARIA   +3 more
core   +2 more sources

Association of high‐dose radioactive iodine therapy with PPM1D‐mutated clonal hematopoiesis in older individuals

Molecular Oncology, EarlyView.
In thyroid cancer patients, high‐dose (≥7.4 GBq) radioactive iodine therapy (RAIT) was associated with a higher prevalence of clonal hematopoiesis (variant allele frequency >2%) in individuals aged ≥50 years (OR = 2.44). In silico analyses showed that truncating PPM1D mutations conferred a selective advantage under these conditions.
Jaeryuk Kim, Sungwoo Bae, Jaeyong Choi, Sun‐Wha Im, Bukyoung Cha, Gyeongseo Jung, Sun Wook Cho, Eul‐Ju Seo, Young Ah Lee, Jin Chul Paeng, Young Joo Park, Jong‐Il Kim   +11 more
wiley   +1 more source

Facilitators and barriers in the donor family interview process from the perspective of hospital staff: a cross-sectional study

Korean Journal of Transplantation, 2023
Background : Obtaining consent from potential donor families is a challenging step in the donation process and is influenced by various factors.
Seyed Mohammad Reza Nejatollahi, Yazdan Abdolmohammadi, Sepideh Ahmadi, Arman Hasanzade, Fatemeh Hosseini, Arshia Mohseni, Shadi Shafaghi, Mojtaba Mokhber Dezfuli, Fariba Ghorbani   +8 more
doaj   +1 more source

SensRORing cholesterol to drive protumoral myelopoiesis

Molecular Oncology, EarlyView.
Bleve et al. uncover a cholesterol‐driven immune evasion pathway, where RORγ‐dependent myelopoiesis shapes tumor immunosuppression. Targeting RORγ and PCSK9 emerges as a strategy to boost cancer immunotherapy. Protumoral myelopoiesis is a determinant of immunoevasion and tumor spread in many malignancies.
Sara Gennari, Luigi Nezi, Teresa Manzo
wiley   +1 more source

Post‐RSV Bronchial Web Formation in a Lung Transplant Recipient: A Case Report

Respirology Case Reports
Bronchial webs (BW) are fibrinous membranes which obstruct the airway lumen. A 33‐year‐old female presented with acute lung allograft dysfunction following a recent respiratory syncytial virus (RSV) infection, having undergone bilateral lung transplant 2 
Nathan Harb, Alexander Mullin, Celeste Mar, Rebecca Pearson, Adrian Havryk, Marshall Plit   +5 more
doaj   +1 more source

Lung Transplantation for Pulmonary Arterial Hypertension: Optimized Referral and Listing Based on an Evolving Disease Concept

Journal of Cardiovascular Development and Disease, 2023
Pulmonary hypertension (PH) was once a devastating and fatal disease entity, the outlook of which has been significantly improved by the continued progress of medical treatment algorithms.
Xiaokun Hu, Ningying Ding, Wanqiu Songchen, Ruifeng Wang, Jing Chen, Ailing Zhong, Jinzhu Nan, Yujie Zuo, Heng Huang, Dong Tian   +9 more
doaj   +1 more source

Lung transplantation for emphysema [PDF]

Annals of Translational Medicine, 2020
Lung transplantation (LT) is proved to be effective in patients with end-stage lung disease who are failing optimal therapy. Chronic obstructive pulmonary disease (emphysema) is the most common indication for adult lung transplantation. As most patients with emphysema (EMP) can survive long term, it could be difficult to decide which patient should be ...
openaire   +4 more sources