Results 51 to 60 of about 1,371,833 (300)

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Bridging the knowledge gap: assessing heart failure awareness and educational needs among clinical physicians

BMC Primary Care
Introduction Heart failure (HF) is a life-threatening disease that affects approximately 26 million people worldwide. Meanwhile, due to the increasing rate of hypertension, diabetes, and ischemic heart diseases as heart failure’s major risk factors, the ...
Hannaneh Yousefi-Koma, Mahshid Haji-Ali, Raha Parnia, Zahra Hajimoradi, Babak Sharif-Kashani, Farah Naghashzadeh, Rozita Jalalian, Behzad Hajimoradi, Ali Bozorg Savoji, Maryam Hajimoradi, Masoume Avateffazeli, Mohammad-Esmail Gheydari, Mohammad-Sadegh Keshmiri, Shadi Shafaghi   +13 more
doaj   +1 more source

Incidence, risk factors, and sequelae of dysphagia mediated aspiration following lung transplantation

, 2022
We aimed to determine dysphagia profiles before and after lung transplantation (prevalence, incidence) and to examine predictors and health-related outcomes of aspiration in individuals undergoing lung transplantation. A retrospective single-center study
Shahmohammadi, Abbas, Colsky, Jennifer, Dallal-York, Justine, Vasilopoulos, Terrie, Plowman, Emily K., Croft, Kayla, Pipkin, Mauricio, DiBiase, Lauren, Segalewitz, Tara, Anderson, Amber, Pelaez, Andres, Machuca, Tiago N.   +11 more
core   +1 more source

Understanding and Mitigating the Risk of Accelerated Biological Aging in Survivors of Cancer: A Scoping Review

Aging and Cancer, EarlyView.
Cancer treatment is associated with measurable acceleration of biological aging across epigenetic, telomere, senescence, and immune biomarkers. However, biomarker validation and interventional strategies remain limited, especially in hematologic malignancies, underscoring the need for standardized multi‐omic aging assessments and adequately powered ...
Moataz Ellithi, Emily Herdman, Danielle Westmark, Vijaya R. Bhatt   +3 more
wiley   +1 more source

The burden of chronic respiratory disease in Western Pacific Region from 1990 to 2021: a systematic analysis for the global burden of disease study 2021

BMC Public Health
Background Chronic respiratory diseases (CRDs) like asthma, chronic obstructive pulmonary disease (COPD), pneumoconiosis, interstitial lung disease (ILD) and pulmonary sarcoidosis pose a major global health challenge.
Chenlong Zha, Xuehan Zhu, Yong Liu, Tao Yan, Jia Liu, Jichang Liu, Fei Gao, Jingyu Chen   +7 more
doaj   +1 more source

IDENTIFYING LEUKOCYTE POPULATIONS AS BIOMARKERS FOR CHRONIC LUNG ALLOGRAFT DYSFUNCTION

Open Respiratory Archives
Introduction: Lung transplantation (LT) is a life-saving therapy for end-stage respiratory diseases, but long-term survival is limited by chronic lung allograft dysfunction (CLAD). Early detection is essential to prevent irreversible damage.
Iván Martínez-Ballestero, Meritxell Boada Pérez, Victoria Ruiz de Miguel, Oriol Grau-Bosch, Eva Revilla-López, Carles Bravo Masgoret, Berta Saez Gimenez, Marta Zapata-Ortega, Manuel López Meseguer, Roser Escobar, Victor Monforte Torres, Cristina Berastegui García, Susana Gómez-Ollés   +12 more
doaj   +1 more source

Influenza Vaccination Responses in Disabled Stroke Patients: A Single‐Center Prospective Observational Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aimed to investigate the immunological response to influenza vaccination, the incidence and severity of influenza infection, and the side effects of the vaccination in patients with ischemic stroke. Methods This prospective observational study was conducted between 2023 and 2024 at Ramathibodi Hospital.
Achiraya Pakngao, Sureerat Suwatcharangoon, Pintip Ngamjanyapron, Kobporn Boonnak, Thanitta Suangtamai, Porpon Rotjanapan   +5 more
wiley   +1 more source

Neurologic Manifestations of Long COVID Affect Adult Females More Severely Than Males

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterize differences in neurologic manifestations of postacute sequelae of SARS‐CoV‐2 infection (Neuro‐PASC) between females and males. Methods Cross‐sectional study of the first consecutive 261 posthospitalization Neuro‐PASC (PNP) and 2068 nonhospitalized Neuro‐PASC (NNP) patients evaluated at the Neuro‐COVID clinic between ...
Hannah Kopinsky, Melissa Lopez, Janet Miller, Millenia Jimenez, Eric M. Liotta, Igor J. Koralnik   +5 more
wiley   +1 more source

First Report of the Korean Lung Transplantation Registry

, 2018
BACKGROUND: The Korean Organ Transplantation Registry (KOTRY) began to register lung transplants in 2015. This is an initial report on the status of patients receiving lung transplants over the past 2 years. METHODS: We analyzed a total of 69 patients
백효채, 김송이, 이진구
core   +1 more source

The Lupus Damage Index Revision Program: Results From the Item Generation and Reduction Phases

Arthritis Care &Research, EarlyView.
Objective A data‐driven and expert/patient consensus‐based project to develop a revised Systemic Lupus International Collaborating Clinics (SLICC)/American College of Rheumatology (ACR) Damage Index (SDI) is under way supported by SLICC, ACR, and the Lupus Foundation of America. Our objective is to report the item generation and reduction phase results
Burak Kundakci, Megan R. W. Barber, Ann E. Clarke, Sindhu R. Johnson, Anselm Mak, Hermine I. Brunner, Murat Inanc, Rosalind Ramsey‐Goldman, Guillermo Ruiz‐Irastorza, Ellen M. Ginzler, John G. Hanly, Alexandra Legge, Cynthia Aranow, Laurent Arnaud, Nathalie Costedoat‐Chalumeau, Dafna D. Gladman, Søren Jacobsen, Michelle Petri, Clovis A. Silva, Évelyne Vinet, Alexandre E. Voskuyl, SDI Revision Literature Review Groups, SDI Revision Delphi Panel, SDI Revision Item Reduction Committee, SDI Revision Clinical Domain Groups, Ian N. Bruce   +25 more
wiley   +1 more source