Results 41 to 50 of about 1,460,646 (299)

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Post‐RSV Bronchial Web Formation in a Lung Transplant Recipient: A Case Report

Respirology Case Reports
Bronchial webs (BW) are fibrinous membranes which obstruct the airway lumen. A 33‐year‐old female presented with acute lung allograft dysfunction following a recent respiratory syncytial virus (RSV) infection, having undergone bilateral lung transplant 2 
Nathan Harb, Alexander Mullin, Celeste Mar, Rebecca Pearson, Adrian Havryk, Marshall Plit   +5 more
doaj   +1 more source

Lung transplantation [PDF]

F1000Prime Reports, 2013
Lung transplantation may be the only intervention that can prolong survival and improve quality of life for those individuals with advanced lung disease who are acceptable candidates for the procedure. However, these candidates may be extremely ill and require ventilator and/or circulatory support as a bridge to transplantation, and lung ...
openaire   +2 more sources

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Breakthrough Tracheobronchial Aspergillosis Caused by Aspergillus calidoustus and Aspergillus niger in a Lung Transplant Recipient Despite Combined Antifungal Prophylaxis

Case Reports in Pulmonology
Aspergillus niger and Aspergillus calidoustus are relatively uncommon pathogens that could cause invasive disease, especially in immunocompromised patients. We present the case of a 61-year-old male with a history of idiopathic pulmonary fibrosis who was
Carlos Enrique Calvache Benavides, Martha Daniela Rodríguez Cárdenas, Sergio Saul Sánchez Salazar, Rogelio de Jesús Treviño Rangel, Adrián Camacho Ortiz   +4 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Primary lung adenocarcinoma in transplanted lung in post bilateral lung transplantation

Clinical Case Reports, 2023
Key Clinical MessagePrimary lung cancer was reported by a bilateral lung transplant patient without any risk factors. Single lung transplantation should be contemplated instead of double lung transplantation as it has been shown to increase the risk of lung cancers.AbstractThis is a case report of a 37‐year‐old woman, with no history of smoking, who ...
Fathima Shafra Mubarak, Sanjay Agrawal, Jagan Rao   +2 more
openaire   +3 more sources

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Bridging the knowledge gap: assessing heart failure awareness and educational needs among clinical physicians

BMC Primary Care
Introduction Heart failure (HF) is a life-threatening disease that affects approximately 26 million people worldwide. Meanwhile, due to the increasing rate of hypertension, diabetes, and ischemic heart diseases as heart failure’s major risk factors, the ...
Hannaneh Yousefi-Koma, Mahshid Haji-Ali, Raha Parnia, Zahra Hajimoradi, Babak Sharif-Kashani, Farah Naghashzadeh, Rozita Jalalian, Behzad Hajimoradi, Ali Bozorg Savoji, Maryam Hajimoradi, Masoume Avateffazeli, Mohammad-Esmail Gheydari, Mohammad-Sadegh Keshmiri, Shadi Shafaghi   +13 more
doaj   +1 more source

IDENTIFYING LEUKOCYTE POPULATIONS AS BIOMARKERS FOR CHRONIC LUNG ALLOGRAFT DYSFUNCTION

Open Respiratory Archives
Introduction: Lung transplantation (LT) is a life-saving therapy for end-stage respiratory diseases, but long-term survival is limited by chronic lung allograft dysfunction (CLAD). Early detection is essential to prevent irreversible damage.
Iván Martínez-Ballestero, Meritxell Boada Pérez, Victoria Ruiz de Miguel, Oriol Grau-Bosch, Eva Revilla-López, Carles Bravo Masgoret, Berta Saez Gimenez, Marta Zapata-Ortega, Manuel López Meseguer, Roser Escobar, Victor Monforte Torres, Cristina Berastegui García, Susana Gómez-Ollés   +12 more
doaj   +1 more source