Results 41 to 50 of about 197,842 (260)

The burden of chronic respiratory disease in Western Pacific Region from 1990 to 2021: a systematic analysis for the global burden of disease study 2021

BMC Public Health
Background Chronic respiratory diseases (CRDs) like asthma, chronic obstructive pulmonary disease (COPD), pneumoconiosis, interstitial lung disease (ILD) and pulmonary sarcoidosis pose a major global health challenge.
Chenlong Zha, Xuehan Zhu, Yong Liu, Tao Yan, Jia Liu, Jichang Liu, Fei Gao, Jingyu Chen   +7 more
doaj   +1 more source

IDENTIFYING LEUKOCYTE POPULATIONS AS BIOMARKERS FOR CHRONIC LUNG ALLOGRAFT DYSFUNCTION

Open Respiratory Archives
Introduction: Lung transplantation (LT) is a life-saving therapy for end-stage respiratory diseases, but long-term survival is limited by chronic lung allograft dysfunction (CLAD). Early detection is essential to prevent irreversible damage.
Iván Martínez-Ballestero, Meritxell Boada Pérez, Victoria Ruiz de Miguel, Oriol Grau-Bosch, Eva Revilla-López, Carles Bravo Masgoret, Berta Saez Gimenez, Marta Zapata-Ortega, Manuel López Meseguer, Roser Escobar, Victor Monforte Torres, Cristina Berastegui García, Susana Gómez-Ollés   +12 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Bridging the knowledge gap: assessing heart failure awareness and educational needs among clinical physicians

BMC Primary Care
Introduction Heart failure (HF) is a life-threatening disease that affects approximately 26 million people worldwide. Meanwhile, due to the increasing rate of hypertension, diabetes, and ischemic heart diseases as heart failure’s major risk factors, the ...
Hannaneh Yousefi-Koma, Mahshid Haji-Ali, Raha Parnia, Zahra Hajimoradi, Babak Sharif-Kashani, Farah Naghashzadeh, Rozita Jalalian, Behzad Hajimoradi, Ali Bozorg Savoji, Maryam Hajimoradi, Masoume Avateffazeli, Mohammad-Esmail Gheydari, Mohammad-Sadegh Keshmiri, Shadi Shafaghi   +13 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Influenza Vaccination Responses in Disabled Stroke Patients: A Single‐Center Prospective Observational Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aimed to investigate the immunological response to influenza vaccination, the incidence and severity of influenza infection, and the side effects of the vaccination in patients with ischemic stroke. Methods This prospective observational study was conducted between 2023 and 2024 at Ramathibodi Hospital.
Achiraya Pakngao, Sureerat Suwatcharangoon, Pintip Ngamjanyapron, Kobporn Boonnak, Thanitta Suangtamai, Porpon Rotjanapan   +5 more
wiley   +1 more source

Pediatric Lung Transplantation [PDF]

Proceedings of the American Thoracic Society, 2009
Abstract Pediatric lung and heart-lung transplantation are viable therapeutic interventions for end stage pulmonary parenchymal or pulmonary vascular diseases. Issues specific to pediatrics include unique diagnoses and increased need for mechanical ventilation before transplant and increased complications related to infection both ...
openaire   +3 more sources

Neurologic Manifestations of Long COVID Affect Adult Females More Severely Than Males

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterize differences in neurologic manifestations of postacute sequelae of SARS‐CoV‐2 infection (Neuro‐PASC) between females and males. Methods Cross‐sectional study of the first consecutive 261 posthospitalization Neuro‐PASC (PNP) and 2068 nonhospitalized Neuro‐PASC (NNP) patients evaluated at the Neuro‐COVID clinic between ...
Hannah Kopinsky, Melissa Lopez, Janet Miller, Millenia Jimenez, Eric M. Liotta, Igor J. Koralnik   +5 more
wiley   +1 more source