Results 71 to 80 of about 1,460,646 (299)

An Epigenetic Fate Converter Based on Nuclei‐Targeting Lipid Nanoparticles Drives Neuronal Programming of Stem Cells for Spinal Cord Repair

Advanced Functional Materials, EarlyView.
Schematic illustration of LNP‐MPG nuclei‐targeting delivery of HMW‐FGF2 promoting histone acetylation to regulate the fate of DPSCs and treat spinal cord injury. LNPs components include pHMW‐FGF2 plasmid, DSPC, Dlin‐MC3‐DMA, cholesterol, and PEG2000, and are modified with MPG to form HMW‐FGF2@LNP‐MPG (HLM). HLM nuclei‐targets DPSCs to deliver HMW‐FGF2,
Heng Zhou, Qiang Qin, Xiqin Li, Hanyu Ding, Chun Xu, Yan He, Qingsong Ye   +6 more
wiley   +1 more source

ISHLT consensus document on lung transplantation in patients with connective tissue disease: Part II: Cardiac, surgical, perioperative, operative, and post-operative challenges and management statements

, 2021
Patients with connective tissue disease (CTD) present unique surgical, perioperative, operative, and postoperative challenges related to the often underlying severe pulmonary hypertension and right ventricular dysfunction.
Shlobin, Oksana, Gothenburg University., King, Christopher, Heresi, Gustavo, Bush, Errol, Pipeling, Matthew, Mercier, Olaf, Bush, Errol E.L., Douglas, Aaron, Franco, Veronica, Göteborgs universitet., Bush, Errol L, Kanwar, Manreet M.K., Dellgren, Göran,, Mazurek, Jeremy J.A., Hadler, Rachel, Shlobin, Oksana Anatolia, Bermudez, Christian, Bermudez, Christian A, Heresi, Gustavo A, Bermudez, Christian C.A., Gutsche, Jacob, Kolatis, Nicholas, Mannem, Hannah, Heresi, Gustavo G.A., Dellgren, Göran, Shlobin, Oksana A, Crespo, Maria M, Mazurek, Jeremy, Mazurek, Jeremy A, Crespo, Maria, Cypel, Marcello, Raman, Sanjeev, Crespo, Maria M.M., Levine, Deborah, Knoop, Christiane, Kanwar, Manreet, Mooney, Joshua, Benvenuto, Luke, Cantu, Edward, Christian A Bermudez, Nicholas Kolatis, Errol L. Bush, Olaf Mercier, Matthew Pipeling, Hannah Mannem, Manreet Kanwar, Marcello Cypel, Christopher King, Oksana A. Shlobin, Maria M. Crespo, Rachel Hadler, Sanjeev Raman, Veronica Franco, Luke Benvenuto, Joshua Mooney, Jeremy A. Mazurek, Christiane Knoop, Gustavo A. Heresi, Aaron Douglas, Deborah Levine, Jacob Gutsche, Edward Cantu, Göran Dellgren   +63 more
core   +1 more source

GDNF‐Enriched Small Extracellular Vesicle‐Loaded ROS‐Scavenging Hydrogel Promotes Neural Regeneration After Spinal Cord Injury

Advanced Healthcare Materials, EarlyView.
A glial cell line‐derived neurotrophic factor (GDNF)‐enriched small extracellular vesicle‐loaded reactive oxygen species (ROS)‐scavenging hydrogel integrates sustained neurotrophic delivery with local modulation of oxidative and inflammatory stress after spinal cord injury. The composite hydrogel improves local vesicle retention, protects neural tissue,
Xingyu Zhu, Zhong Liu, Kewei Li, Yuhong Fan, Kangjia Yang, Xiaopeng Sun, Hang Shi, Lixuan Sun, Yang Lou, Min Wang, Peipei Wu, Hui Qian, Qiang Fu, Hua Ding   +13 more
wiley   +1 more source

Contribution of 3D visualization and printing in teaching lung segments anatomy

3D Printing in Medicine
Background The knowledge and understanding of the anatomy of lung segments is of great importance while segmentectomies are increasingly performed. To introduce new technologies and tools in anatomy teaching could help students to improve their skills ...
Gabrielle Drevet, Valentin Soldea, Sylvain Gouttard, Melia Virely, Jean-Michel Maury, François Tronc   +5 more
doaj   +1 more source

The impact of gastrointestinal dysmotility on the aerodigestive microbiome of pediatric lung transplant recipients

, 2021
BACKGROUND: Delayed gastric emptying has been associated with increased graft rejection, although the mechanism of this association is not known. This study aims to investigate the interrelationship between delays in gastrointestinal motility and the ...
Lurie, Margot,, Lötstedt, Britta,, Boyer, Debra,, Kane, Madeline,, Setchell, Kenneth,, Lundeberg, Joakim,, Visner, Gary,, Narvaez-Rivas, Monica,, Alm, Eric,, Rosen, Rachel,, Freiberger, Dawn,, DiFilippo, Courtney,   +11 more
core   +1 more source

Anti‐Inflammatory and Neuroactive Effects of Polymer‐Coated Iron Oxide Nanoparticles Functionalized With Interleukin 4 for Spinal Cord Injury

Advanced Healthcare Materials, EarlyView.
Polymer‐coated IONPs functionalized with IL‐4 display respective neuroactive and anti‐inflammatory actions on neural progenitor cells and macrophages/microglia in vitro. When examined chronically in a rat experimental model of spinal cord injury, rGO scaffolds carrying these nanosystems adequately integrate into the lesion, significantly reduce ...
Julia Martínez‐Ramírez, Paloma Lozano‐Picazo, María de Lamo‐Atencia, Andrea Ferreras, Esther Benayas‐Martín, Elena Fernández‐López, Marina Sánchez‐Petidier, Verónica Barranco‐Maresca, Víctor Caz, Anne des Rieux, Juliana M. Rosa, María del Puerto Morales, María C. Serrano   +12 more
wiley   +1 more source

The impaired diaphragmatic function after bilateral lung transplantation : A multifactorial longitudinal study

, 2020
BACKGROUND: Lung transplantation is a complex but effective treatment of end-stage pulmonary disease. Among the post-operative complications, phrenic nerve injury, and consequent diaphragmatic dysfunction are known to occur but are hitherto poorly ...
Frykholm, Peter,, LoMauro, Antonella,, Vergari, Maurizio,, Nosotti, Mario,, Privitera, Emilia,, Morlacchi, Letizia,, Righi, Ilaria,, Nigro, Martina,, Aliverti, Andrea,, Palleschi, Alessandro,, Tarsia, Paolo,   +10 more
core   +1 more source

Hydrogel‐Based Airway‐on‐Tube With Perfusable Endothelial Lumen and Outward Epithelialization

Advanced Materials, EarlyView.
A hydrogel‐based airway‐on‐tube platform featuring a perfusable endothelial lumen and outward epithelialization is presented. The system supports primary human bronchial epithelial and lung microvascular endothelial coculture under air‐liquid interface conditions.
Ali Doryab, Jack F. Murphy, Michael Bartolf‐Kopp, Jenny C‐C Hsin, Alice Chernaik, Frank McCaughan, Yan Yan Shery Huang, Tomasz Jungst, Jürgen Groll   +8 more
wiley   +1 more source

Successful lung transplantation for posttraumatic adult respiratory distress syndrome after extracorporeal membrane oxygenation support

, 1992
A severe adult respiratory distress syndrome after bilateral lung contusion was successfully treated by extracorporeal membrane oxygenation and subsequent double-lung transplantation in a 19-year-old man.
Wagner, T O, Müller, K M, Demertzis, Stefanos, Haverich, A, Nerlich, M, Ziemer, G, Borst, H G   +6 more
core   +1 more source

Mesenchymal stromal cell therapy during ex vivo lung perfusion ameliorates ischemia-reperfusion injury in lung transplantation

, 2019
The application of mesenchymal stromal cell (MSC)–based therapy during ex vivo lung perfusion (EVLP) could repair injured donor lungs before transplantation.
Akihiro Ohsumi, Coutinho, Rafael, Davies, John E., Hwang, David M., Pipkin, Mauricio, Rohin K. Iyer, Mingyao Liu, Marcelo Cypel, Keshavjee, Shaf, Ohsumi, Akihiro, Kanou, Takashi, Daisuke Nakajima, Tomohito Saito, John E. Davies, Manyin Chen, Stephen Juvet, Mordant, Pierre, Yui Watanabe, Shaf Keshavjee, Chen, Manyin, Saito, Tomohito, Lindsay Caldarone, Mauricio Pipkin, Thomas K. Waddell, Tereza Martinu, Iyer, Rohin K., Liu, Mingyao, Takashi Kanou, David M. Hwang, Juvet, Stephen, Cypel, Marcelo, Waddell, Thomas K., Martinu, Tereza, Rafael Coutinho, Caldarone, Lindsay, Lam, Ryan, Nakajima, Daisuke, Ryan Lam, Watanabe, Yui, Pierre Mordant   +39 more
core   +1 more source