Results 41 to 50 of about 11,593,090 (249)

Congenital diaphragmatic hernia: 2D lung area and 3D lung volume measurements of the contralateral lung to predict postnatal outcome

, 2008
Objectives: The aim of the study was to evaluate the prognostic utility of 2D lung area and 3D lung volume measurements of the contralateral lung in infants with congenital diaphragmatic hernia. Methods: At 18-37 weeks' gestation between 1 and 5 scans of
Gerards, F.A., Twisk, J.W., Twisk, JWR, Vugt, JMG, Tibboel, Dick, van Vugt, J.M.G., Gerards, FA, Tibboel, D.   +7 more
core   +1 more source

Respiratory health problems in adolescents living near main roads in the Upper Silesian industrial zone, Poland

International Journal of Occupational Medicine and Environmental Health, 2019
Objectives This study explores the association between self-reported exposure to traffic-related air pollution and respiratory health symptoms, as well as lung functions and skin prick tests in adolescents living in the vicinity of main roads.
Michał Skrzypek, Małgorzata Kowalska, Joanna Kasznia-Kocot, Elżbieta M. Czech, Ewa Niewiadomska   +4 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Respiratory Function Assessment through Kinematic Analysis of Chest Wall Movements: Effects of Position and Gender [PDF]

Journal of Biomedical Physics and Engineering
Background: The effect of position and gender on chest movements and respiratory volumes is controversial and investigated in only a few studies.Objective: This study aimed to investigate the effects of position and gender on the breathing pattern during
Bahar Shaghayeghfard, Mohammad Taghi Karimi, Leila Abbasi, Mohsen Razeghi   +3 more
doaj   +1 more source

Investigating the relationships among lung function variables in chronic obstructive pulmonary disease in men [PDF]

PeerJ, 2019
Background In patients with chronic obstructive pulmonary disease (COPD), the independent contributions of individual lung function variables to outcomes may be lower when they are modelled together if they are collinear.
Ming-Lung Chuang, I-Feng Lin
doaj   +2 more sources

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Flow-Volume Parameters in COPD Related to Extended Measurements of Lung Volume, Diffusion, and Resistance

Pulmonary Medicine, 2013
Classification of COPD into different GOLD stages is based on forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) but has shown to be of limited value.
Linnea Jarenbäck, Jaro Ankerst, Leif Bjermer, Ellen Tufvesson   +3 more
doaj   +1 more source

Distribution of transpulmonary pressure during one-lung ventilation in pigs at different body positions

Frontiers in Physiology, 2023
Background. Global and regional transpulmonary pressure (PL) during one-lung ventilation (OLV) is poorly characterized. We hypothesized that global and regional PL and driving PL (ΔPL) increase during protective low tidal volume OLV compared to two-lung ...
Jakob Wittenstein, Martin Scharffenberg, Xiuli Yang, Xiuli Yang, Thomas Bluth, Thomas Kiss, Thomas Kiss, Marcus J. Schultz, Patricia R. M. Rocco, Paolo Pelosi, Paolo Pelosi, Marcelo Gama de Abreu, Marcelo Gama de Abreu, Marcelo Gama de Abreu, Robert Huhle   +14 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source