Results 51 to 60 of about 11,593,090 (249)

Lung volume segmentation in fetal MRI: super-resolution reconstructions improve inter-rater reliability

European Radiology Experimental
Background Fetal MRI is increasingly used to investigate fetal lung pathologies, and super-resolution (SR) algorithms could be a powerful clinical tool for this assessment.
Kelly Payette, Julia Geiger, Michael Zellner, Céline Steger, Christian J. Kellenberger, Ruth Tuura, Raimund Kottke, Andras Jakab   +7 more
doaj   +1 more source

Determination of reliable lung function parameters in intubated mice

Respiratory Research, 2019
Background Animal models and, in particular, mice models, are important tools to investigate the pathogenesis of respiratory diseases and to test potential new therapeutic drugs. Lung function measurement is a key step in such investigation.
Eline Bonnardel, Renaud Prevel, Marilyne Campagnac, Marielle Dubreuil, Roger Marthan, Patrick Berger, Isabelle Dupin   +6 more
doaj   +1 more source

Correlation Analysis of the Lung Volume Reduction and the Lung Function Loss 
after the Thoracoscopic Lobectomy

Chinese Journal of Lung Cancer, 2022
Background and objective To investigate the correlation between the reduction of lung volume and the degree of lung function damage after lobectomy. Methods A total of 131 patients (72 males and 59 females) who underwent thoracoscopic lobectomy in the ...
Zhenzhou ZHAI, Jun ZHAO, Chang LI, Cheng DING, Chun XU   +4 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Dynamic and volumetric variables reliably predict fluid responsiveness in a porcine model with pleural effusion [PDF]

, 2013
Background: The ability of stroke volume variation (SVV), pulse pressure variation (PPV) and global end-diastolic volume (GEDV) for prediction of fluid responsiveness in presence of pleural effusion is unknown.
Meybohm, Patrick, Matthias Gruenewald, Grünewald, Matthias Lars, Jan Schöttler, Katharina Heß, Steinfath, Markus, Heß, Katharina, Ole Broch, Jochen Renner, Schöttler, Jan, Patrick Meybohm, Bein, Berthold, Gruenewald, Matthias, Bein, Berthold Helmut, Berthold Bein, Renner, Jochen, Broch, Ole, Markus Steinfath   +17 more
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Effect on smoking quit rate of telling patients their lung age: the Step2quit randomised controlled trial [PDF]

, 2008
Objective To evaluate the impact of telling patients their estimated spirometric lung age as an incentive to quit smoking.Design Randomised controlled trial.Setting Five general practices in Hertfordshire, England.Participants 561 current smokers aged ...
Griffin, M, Trisha Greenhalgh, Dent, R, Greenhalgh, T, Mark Griffin, Gary Parkes, Greenhalgh, Trisha, Richard Dent, Parkes, G   +8 more
core   +1 more source

EFFECT OF DIFFERENT SITTING POSTURES IN WHEELCHAIR ON LUNG CAPACITY, EXPIRATORY FLOW IN PATIENTS OF SPINAL CORD INJURY (SCI) OF SPINE INSTITUTE OF AHMEDABAD

National Journal of Medical Research, 2012
Background: People with Spinal Cord Injury (SCI) frequently experience various complications. Subjects with SCI are in a sitting posture for prolonged periods of time, it is important to know how different sitting postures affect pulmonary function ...
Namrata P Prajapati , Anjali R Bhise
doaj  

Measuring pulmonary function in COPD using quantitative chest computed tomography analysis

European Respiratory Review, 2021
COPD is diagnosed and evaluated by pulmonary function testing (PFT). Chest computed tomography (CT) primarily serves a descriptive role for diagnosis and severity evaluation.
Jens T. Bakker, Karin Klooster, Rozemarijn Vliegenthart, Dirk-Jan Slebos   +3 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source