Results 61 to 70 of about 11,593,090 (249)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

PEEP decreases atelectasis and extravascular lung water but not lung tissue volume in surfactant-washout lung injury.

, 2003
OBJECTIVE: To examine the effects of positive end-expiratory pressure (PEEP) on extravascular lung water (EVLW), lung tissue, and lung volume. DESIGN AND SETTING: Experimental animal study at a university research facility.
JOACHIM A, WEISSER G, PELOSI, PAOLO PASQUALINO, ROTH H, HERRMANN P, QUINTEL M., LUECKE T   +6 more
core   +1 more source

The avian lung-associated immune system [PDF]

, 2006
The lung is a major target organ for numerous viral and bacterial diseases of poultry. To control this constant threat birds have developed a highly organized lung-associated immune system.
Reese, Sven, Dalamani, Grammatia, Kaspers, Bernd, Sven Reese, Grammatia Dalamani, Bernd Kaspers   +5 more
core   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Integrating fetal pulmonary artery doppler with 2D lung volumetry to predict neonatal respiratory distress

The Egyptian Journal of Radiology and Nuclear Medicine
Objectives This study aims to evaluate fetal lung development through volumetric measurements and Doppler assessments of the main pulmonary artery, thereby correlating these findings with neonatal respiratory distress and Apgar score.
Marwa Elsayed Abdelrahman Ibrahim, Mohamed Adel Rezk, Hossam El-Khouli, Ahmed Shaaban Owais   +3 more
doaj   +1 more source

Dual-energy micro-CT functional imaging of primary lung cancer in mice using gold and iodine nanoparticle contrast agents: a validation study. [PDF]

PLoS ONE, 2014
PURPOSE:To provide additional functional information for tumor characterization, we investigated the use of dual-energy computed tomography for imaging murine lung tumors. Tumor blood volume and vascular permeability were quantified using gold and iodine
Jeffrey R Ashton, Darin P Clark, Everett J Moding, Ketan Ghaghada, David G Kirsch, Jennifer L West, Cristian T Badea   +6 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Growth pattern analysis of murine lung neoplasms by advanced semi-automated quantification of micro-CT images. [PDF]

PLoS ONE, 2013
Computed tomography (CT) is a non-invasive imaging modality used to monitor human lung cancers. Typically, tumor volumes are calculated using manual or semi-automated methods that require substantial user input, and an exponential growth model is used to
Minxing Li, Artit Jirapatnakul, Alberto Biancardi, Mark L Riccio, Robert S Weiss, Anthony P Reeves   +5 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Reproducibility of a semiautomatic lobar lung tissue assignment technique on noncontrast CT scans: a study on swine animal model

European Radiology Experimental
Background To evaluate the reproducibility of a vessel-specific minimum cost path (MCP) technique used for lobar segmentation on noncontrast computed tomography (CT).
Nile Luu, Nathan Van, Alireza Shojazadeh, Yixiao Zhao, Sabee Molloi   +4 more
doaj   +1 more source