Results 81 to 90 of about 815,365 (380)

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Growth pattern analysis of murine lung neoplasms by advanced semi-automated quantification of micro-CT images. [PDF]

PLoS ONE, 2013
Computed tomography (CT) is a non-invasive imaging modality used to monitor human lung cancers. Typically, tumor volumes are calculated using manual or semi-automated methods that require substantial user input, and an exponential growth model is used to
Minxing Li, Artit Jirapatnakul, Alberto Biancardi, Mark L Riccio, Robert S Weiss, Anthony P Reeves   +5 more
doaj   +1 more source

Measuring pulmonary function in COPD using quantitative chest computed tomography analysis

European Respiratory Review, 2021
COPD is diagnosed and evaluated by pulmonary function testing (PFT). Chest computed tomography (CT) primarily serves a descriptive role for diagnosis and severity evaluation.
Jens T. Bakker, Karin Klooster, Rozemarijn Vliegenthart, Dirk-Jan Slebos   +3 more
doaj   +1 more source

Effect of external PEEP in patients under controlled mechanical ventilation with an auto-PEEP of 5 cmH2O or higher. [PDF]

, 2016
In some patients with auto-positive end-expiratory pressure (auto-PEEP), application of PEEP lower than auto-PEEP maintains a constant total PEEP, therefore reducing the inspiratory threshold load without detrimental cardiovascular or respiratory effects.
Amodeo, Guido, Bernardini, Achille, Berruto, Francesco, Filippini, Matteo, Fiorillo, Marialinda, Grazioli, Michele, Lucangelo, U., Marsilia, Paolo F., Minelli, Cosetta, Natalini, Giuseppe, Pennestr\uec, Vincenzo, Peratoner, Alberto, Rosano, Antonio, Testa, Marco, Tinnirello, Andrea, Tuzzo, Daniele, Ventilab, Group   +16 more
core   +1 more source

Unveiling unique protein and phosphorylation signatures in lung adenocarcinomas with and without ALK, EGFR, and KRAS genetic alterations

Molecular Oncology, EarlyView.
Proteomic and phosphoproteomic analyses were performed on lung adenocarcinoma (LUAD) tumors with EGFR, KRAS, or EML4–ALK alterations and wild‐type cases. Distinct protein expression and phosphorylation patterns were identified, especially in EGFR‐mutated tumors. Key altered pathways included vesicle transport and RNA splicing.
Fanni Bugyi, Mirjam Balbisi, Simon Sugár, Lóránd Váncza, Eszter Regős, Ilona Kovalszky, Ibolya Laczó, Tünde Harkó, Gábor Kecskeméti, Zoltán Szabó, Judit Moldvay, László Drahos, Lilla Turiák   +12 more
wiley   +1 more source

EFFECT OF DIFFERENT SITTING POSTURES IN WHEELCHAIR ON LUNG CAPACITY, EXPIRATORY FLOW IN PATIENTS OF SPINAL CORD INJURY (SCI) OF SPINE INSTITUTE OF AHMEDABAD

National Journal of Medical Research, 2012
Background: People with Spinal Cord Injury (SCI) frequently experience various complications. Subjects with SCI are in a sitting posture for prolonged periods of time, it is important to know how different sitting postures affect pulmonary function ...
Namrata P Prajapati , Anjali R Bhise
doaj  

Olaparib synergy screen reveals Exemestane induces replication stress in triple‐negative breast cancer

Molecular Oncology, EarlyView.
Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh, Liping Su, Suet Lin Chia, Xiaohe Tian, Haslina Ahmad, Martin R. Gill   +5 more
wiley   +1 more source

What every ICU clinician needs to know about the cardiovascular effects caused by abdominal hypertension [PDF]

, 2015
The effects of increased intra-abdominal pressure (IAP) on cardiovascular function are well recognized and include a combined negative effect on preload, afterload and contractility.
De Keulenaer, Bart L, De Waele, Jan, Malbrain, Manu LNG   +2 more
core   +1 more source

RKIP overexpression reduces lung adenocarcinoma aggressiveness and sensitizes cells to EGFR‐targeted therapies

Molecular Oncology, EarlyView.
RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha, Joana Pinheiro, Rui F. Marques, Patrícia Fontão, Diana Cardoso‐Carneiro, Adriana Mendes, Izabela N. F. Gomes, Ana Carolina Laus, Renato J. da Silva‐Oliveira, Rui Manuel Reis, Olga Martinho   +10 more
wiley   +1 more source

Acute and Chronic Effects of Smoking on Inflammation Markers in Exhaled Breath Condensate in Current Smokers [PDF]

, 2010
Background: Long-term cigarette smoking is associated with pulmonary inflammation, but the acute effects of smoking have been less well studied. Analysis of the exhaled breath condensate (EBC) can provide noninvasive markers that might be indicative of ...
Bals, Robert, Herr, Christian, Jörres, Rudolf A., Koczulla, A. Rembert, Noeske, Sarah, Römmelt, Horst, Vogelmeier, Claus   +6 more
core   +1 more source