Results 101 to 110 of about 327,203 (311)

Condition‐Associated Pattern Extraction and Recovery From Multi‐Condition Single‐Cell RNA‐seq Data With CAPER

Advanced Science, EarlyView.
Decoupling biological signals from unwanted variation in multi‑condition single‑cell RNA sequencing data remains challenging. CAPER disentangles condition‑associated biological effects from sample heterogeneity through matrix factorization, producing interpretable latent factors and a batch‑corrected expression matrix.
Ye Li, Jin Ning, An Wang, Minxi Shi, Yuanze Chen, Guoliang Liu, Shiquan Sun   +6 more
wiley   +1 more source

Senkyunolide I Inhibits mtDNA‐cGAS‐STING Signaling in Macrophages via Targeting VDAC1 Oligomerization to Attenuate Ulcerative Colitis

Advanced Science, EarlyView.
In macrophages, senkyunolide I (SEI) directly targets the K12 residue of VDAC1 to inhibit its stress‐induced oligomerization, a critical upstream event that effectively prevents mitochondrial DNA release and subsequent cGAS‐STING pathway activation.
Zhiming Ye, Yihang Huang, Bohao Han, Lei Zhang, Can Yu, Yang Yang, Bing Liu, Yongping Jian, Zhixiang Xu, Cheng Zeng   +9 more
wiley   +1 more source

LP-199 Medications given to patients with incomplete systemic lupus erythematosus

Lupus Science and Medicine, 2023
Anastasiia Shumilova, Yulia Gorbunova, Tatiana Popkova, Tatiana Panafidina, Liubov Kondrateva, Alexandr Lila   +5 more
doaj   +1 more source

Long-term safety and efficacy of the combination of belimumab and rituximab in the treatment of severe and refractory SLE: a preliminary report

Lupus Science and Medicine
Objective Combination therapy with rituximab and belimumab is a novel treatment strategy for severe SLE and lupus nephritis. Phase II studies have shown promising results, although long-term data are currently lacking.
Tineke Kraaij, Cees van Kooten, Y K Onno Teng, Tom Huizinga, Eline J Arends, Robbert J Goekoop, Ton Rabelink, Mieke van Schaik, Marjolein J A L Wetzels, Stéphanie H Verbruggen, Sandra W van der Kooij, Sylvia W A Kamerling   +11 more
doaj   +1 more source

Further description of early clinically silent lupus nephritis.

, 2006
Thirty silent lupus nephritis (SLN) patients were compared to 16 individuals bearing overt lupus nephritis (OLN). Results included: years of systemic lupus erythematosus (SLE) diagnosis were significantly earlier (4.6 +/- 2.8 years) in SLN than in OLN (7.
Pinto, J.A., Bianco Colmenares, Nicolás E., Vargas-Arenas, R.E., Zabaleta-Lanz, M.E., Tapanes, F.J., Barrios, Y., Muñoz, L.E., Daboin, I.   +7 more
core  

Irreversible blindness in juvenile systemic lupus erythematosus

, 2011
Blindness caused by severe vasculitis or uveitis is rare in juvenile systemic lupus erythematosus (JSLE) patients. In a 27-year period, 5367 patients were followed at our Paediatric Rheumatology Division and 263 (4.9%) patients had JSLE (American College
AIKAWA, N. E., SILVA, C. A., SALLUM, A. M. E., JESUS, A. A., ALMEIDA, R. T., SA, L. C. F.   +5 more
core   +1 more source

Nano Proton Scavengers Modulate Endosomal pH to Inhibit Microglial Activation and Enhance Stroke Recovery

Advanced Science, EarlyView.
Amphiphilic sulfonated chitosan nanoparticles buffer endo/lysosomal acidity in microglia by limiting V‐ATPase membrane recruitment and restoring endosomal homeostasis. Following systemic administration, they accumulate in the ischemic hemisphere partly through association with infiltrating immune cells, suppress TLR3/IRF3 and TLR4/NF‐κB signaling ...
Xuanlin Wang, Yujing Shi, Zehua Gao, Jing Wang, Changsheng Liu   +4 more
wiley   +1 more source

LP-113 Systemic lupus erythematosus induced by experimental therapy with a combination of monoclonal antibodies against the sars-cov2 surface s-protein

Lupus Science and Medicine, 2023
Mariia Aristova, Tatiana Popkova, Tatiana Panafidina, Anna Misiyuk, Magomed Kurbanmagomedov   +4 more
doaj   +1 more source

Lupus vulgar, reporte de un caso

, 2018
Lupus vulgaris is one of the most common forms of cutaneous tuberculosis. It is a chronic and benign form that usually occurs in patients that had been previously sensitized to Mycobacterium tuberculosis and its diagnosis is based mainly in the clinical ...
Maldonado, Juliana; Pontificia Universidad Javeriana, Hoyos, Victoria; Universitario San Ignacio, Mejía, Maddy; Universitario San Ignacio   +2 more
core  

Correlation between the Modified Systemic Lupus Erythematosus Disease Activity Index 2000 and the European Consensus Lupus Activity Measurement in juvenile systemic lupus erythematosus

, 2016
Objective The objective of this study was to assess Modified Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K) and European Consensus Lupus Activity Measurement (ECLAM) disease activity correlation in addition to their respective ...
Corrente, J. E. [UNESP], Corrente, J. E., Saad-Magalhães, C., Sato, J. O., Sato, J. O. [UNESP], Saad-Magalhães, C. [UNESP]   +5 more
core   +1 more source