Results 111 to 120 of about 327,203 (311)

Macrophage RSAD2 Couples mtDNA Synthesis With a Self‐Amplifying Inflammatory Circuit to Orchestrate Tissue Repair

Advanced Science, EarlyView.
Macrophage RSAD2 dually regulates CMPK2—the rate‐limiting enzyme for mitochondrial DNA synthesis—by suppressing its ubiquitination and promoting its phosphorylation via Csnk2a2 recruitment. This amplifies mtDNA production, which simultaneously activates a cGAS‐STING‐IRF3‐RSAD2 feedforward loop and the NLRP3 inflammasome, driving a self‐sustaining ...
Haomiao Yuan, Shukui Du, Chunfei Li, Xinjie Li, Shuyang Mu, Anran Qu, Hengxu Yan, Chongchong Xu, Jinnong Yang, Jingkai Sun, Yijun Wang, Jiayang Xiao, Fuyuan Zhang, Linlin Wang, Tiegang Li, Rui Zhao, Dawei Guan   +16 more
wiley   +1 more source

LP-203 The new markers of systemic lupus erythematosus activity: focus on interleukin (IL)-1b and soluble IL-2 receptor

Lupus Science and Medicine, 2023
Mariia Aristova, Tatyana Panafidina, Yulia Gorbunova, Anastasiya Avdeeva, Tatyana Popkova   +4 more
doaj   +1 more source

Circus Lupus, Super Genius promotional poster, 1992

, 1992
Poster promoting an album, "Super Genius" by the Washington, D.C. punk band, Circus Lupus.
Dischord Records
core  

Methotrexate therapy in systemic lupus erythematosus

, 2001
There are 12 non-controlled and only two controlled studies using methotrexate (MTX) in a total of 207 SLE patients in the literature. the majority of these studies evaluated mainly cutaneous and/or articular involvement and attained good results.
Sato, E. I.
core   +1 more source

Upadacitinib Restrains the Pathogenic Fitness of CD4+ T Cells and Aberrant B Cell Programming in Optic Neuritis

Advanced Science, EarlyView.
Single‐cell profiling and functional perturbation reveal coordinated JAK1‐pSTAT3 downstream programs in optic neuritis, including MCL1‐dependent fitness of pathogenic CD4+ Tem cells and glycolysis‐linked, cholesterol‐sensitive B‐cell responses associated with RORA. Upadacitinib disrupts this reciprocal T‐B‐cell circuit and alleviates neuroinflammation,
Gengchen Jiang, Qi Jiang, Lian Han, Yue Peng, Xingyu Liu, Tong Yang, Hao Huang, Jiaying Liu, Yuan Gao, Hui Yang, Wenjun Zou, Zhaohuai Li, Wenru Su   +12 more
wiley   +1 more source

Ovarian necrotizing vasculitis in a patient with lupus

, 2009
Ovarian vasculitis is a rare complication seen in the reproductive system and has been described in only one patient with lupus and a few patients with other rheumatic conditions (polyarteritis nodosa, giant cell arteritis, scleroderma). Three additional
SILVA, C. A. A., MEDEIROS, A. C. de, CAPELOZZI, V., BONFA, E., CARVALHO, J. F. de, PEREIRA, R. M. R.   +5 more
core   +1 more source

Mitochondria‐Targeted Nanotherapeutics: A Promising Strategy in Modulating Mitochondrial Function, Transfer, and Transplantation

Advanced Science, EarlyView.
This review summarizes the pathogenic role of mitochondria in diseases and highlights mitochondrial transfer and transplantation as emerging therapeutic strategies. It systematically discusses how nanomaterials are engineered to facilitate these processes, and critically examines the current challenges and future perspectives for their clinical ...
Yuanyuan Su, Zhiyan Gong, Jiao Mu, Lili Huang, Pengfei Yang, Chenli Zhang, Lingshan Zhao, Liling Yang, Jun Deng, Xiaohui Liao   +9 more
wiley   +1 more source

LP-048 Characteristics and clinical outcome of incomplete systemic lupus erythematosus

Lupus Science and Medicine, 2023
Anastasiia Shumilova, Evgeniy Nasonov, Yulia Gorbunova, Tatiana Popkova, Tatiana Panafidina, Liubov Kondrateva, Alexandr Lila   +6 more
doaj   +1 more source

Silent nephritis in systemic lupus erythematosus

, 2003
Silent lupus nephritis (SLN) was investigated in 42 renal asymptomatic patients and compared with 49 untreated patients with overt lupus nephropathy (OLN).
Zabaleta-Lanz, M., Tápanes, F., Bianco Colmenares, Nicolás E., Vargas-Arenas, R.E., Daboin, I., Atahualpa Pinto, J.   +5 more
core  

Prognostically distinct clinical patterns of systemic lupus erythematosus identified by cluster analysis.

, 2009
The objective of this study was to evaluate the patterns of clinical manifestations and their mortality in a large cohort of Chinese patients with systemic lupus erythematosus.
Lau, CS, To, CH, Wong, RW, Tang, SS, Ying, SK, Mok, CC   +5 more
core   +1 more source