Results 11 to 20 of about 411,751 (361)

A Toll for lupus [PDF]

, 2005
Toll-like receptor (TLR)-9 recognizes CpG motifs in microbial DNA. TLR9 signalling stimulates innate antimicrobial immunity and modulates adaptive immune responses including autoimmunity against chromatin, e.g., in systemic lupus erythematosus (SLE ...
Anders, Hans-Joachim, H-J Anders
core   +1 more source

Joint involvement in patients affected by systemic lupus erythematosus: application of the swollen to tender joint count ratio

Reumatismo, 2015
Joint involvement is a common manifestation in systemic lupus erythematosus (SLE). According to the SLE disease activity index 2000 (SLEDAI-2K), joint involvement is present in case of ≥2 joints with pain and signs of inflammation.
E. Cipriano, F. Ceccarelli, L. Massaro, F. R. Spinelli, C. Alessandri, C. Perricone, G. Valesini, F. Conti   +7 more
doaj   +1 more source

Lack of the long pentraxin PTX3 promotes autoimmune lung disease but not glomerulonephritis in murine systemic lupus erythematosus. [PDF]

, 2011
The long pentraxin PTX3 has multiple roles in innate immunity. For example, PTX3 regulates C1q binding to pathogens and dead cells and regulates their uptake by phagocytes. It also inhibits P-selectin-mediated recruitment of leukocytes.
Mantovani Alberto, Heni Eka Susanti, Adriana Migliorini, A. Migliorini, Susanti, Heni Eka, Hans-Joachim Anders, Christoph Römmele, Kulkarni, Onkar P., M. Lech, Cecilia Garlanda, Kulkarni Onkar P., Lech, Maciej, Lech Maciej, Garlanda Cecilia, C. Garlanda, Römmele, Christoph, Migliorini Adriana, Mantovani, Alberto, Alberto Mantovani, Anders Hans-Joachim, Onkar P Kulkarni, Maciej Lech, Susanti Heni Eka, A. Mantovani, Anders, Hans-Joachim, Römmele Christoph, H.E. Susanti, Migliorini, Adriana, O.P. Kulkarni, C. Römmele, H. J. Anders, Garlanda, Cecilia, Onkar P. Kulkarni   +32 more
core   +1 more source

Anti-carbamylated protein antibodies as a new biomarker of erosive joint damage in systemic lupus erythematosus

Arthritis Research & Therapy, 2018
Background The application of more sensitive imaging techniques, such as ultrasonography (US), changed the concept of non-erosive arthritis in systemic lupus erythematosus (SLE), underlining the need for biomarkers to identify patients developing the ...
Fulvia Ceccarelli, Carlo Perricone, Tania Colasanti, Laura Massaro, Enrica Cipriano, Monica Pendolino, Francesco Natalucci, Riccardo Mancini, Francesca Romana Spinelli, Guido Valesini, Fabrizio Conti, Cristiano Alessandri   +11 more
doaj   +1 more source

Gradual Glucocorticosteroid Withdrawal Is Safe in Clinically Quiescent Systemic Lupus Erythematosus

ACR Open Rheumatology, 2021
Objectives Patients with systemic lupus erythematosus (SLE) are usually treated with glucocorticosteroids even during periods of clinically quiescent disease.
Konstantinos Tselios, Dafna D. Gladman, Jiandong Su, Murray B. Urowitz   +3 more
doaj   +1 more source

Lupus nephritis and lupus band test [PDF]

Postgraduate Medical Journal, 1981
Summary Twenty-seven patients with histologically confirmed lupus nephritis were studied to identify the incidence of lupus band and its significance to histological patterns of nephritis and complement levels. It was found that the kidney involvement is 2.5 times more frequent in lupus band positive patients.
B A, Adam, F, Wang, L M, Looi, K, Prathap   +3 more
openaire   +2 more sources

A randomised study of rituximab and belimumab sequential therapy in PR3 ANCA-associated vasculitis (COMBIVAS): design of the study protocol

Trials, 2023
Background Sequential B cell-targeted immunotherapy with BAFF antagonism (belimumab) and B cell depletion (rituximab) may enhance B cell targeting in ANCA-associated vasculitis (AAV) through several mechanisms.
Mark E. McClure, Seerapani Gopaluni, James Wason, Robert B. Henderson, Andre Van Maurik, Caroline C.O. Savage, Charles D. Pusey, Alan D. Salama, Paul A. Lyons, Jacinta Lee, Kim Mynard, David R. Jayne, Rachel B. Jones, on behalf the COMBIVAS investigators   +13 more
doaj   +1 more source

Kidney disease in lupus is not always 'lupus nephritis' [PDF]

Arthritis Research & Therapy, 2013
In lupus erythematosus, elevated serum creatinine levels and urinary abnormalities implicate a kidney disorder, which may not always be lupus nephritis as defined by the current classification of the International Society of Nephrology/Renal Pathology Society.
Anders, Hans-Joachim, Weening, Jan J.
openaire   +3 more sources

Early Discoid Lupus Erythematosus Protects Against Renal Disease In Patients With Systemic Lupus Erythematosus: Longitudinal Data From A Large Latin American Cohort

, 2017
The objective of this study was to examine whether early discoid lupus erythematosus (DLE) would be a protective factor for further lupus nephritis in patients with systemic lupus erythematosus (SLE).
V.; Alvarellos, E. M.; Chacon-Diaz, M. J.; Sato, A.; Caeiro, L. T. L.; Neira, R.; Drenkard, C., E. I.; Soriano, G. J.; Aspey, D.; Saurit, F.; Haye Salinas, M. H.; Acevedo-Vasquez, O.; Iglesias-Gamarra, L. D.; Bao, G.; Cardiel, Pons-Estel, E. R.; Costallat, A.; Reyes-Llerena, G.; Pons-Estel, B. A.; Wojdyla   +19 more
core   +3 more sources

New efforts to incorporate patient-reported outcomes into lupus clinical trials: report of the community meeting convened by the Lupus Accelerating Breakthroughs Consortium (Lupus ABC), 16–17 October 2024

Lupus Science and Medicine
The Lupus Research Alliance formed the Lupus Accelerating Breakthroughs Consortium (Lupus ABC) in 2023 as a public-private partnership with investigators, pharmaceutical companies, the Food and Drug Administration, National Institutes of Health, patient ...
, Meenakshi Jolly, Zahi Touma, Anca D Askanase, Patricia Katz, Cindy Coney, Wen-Hung Chen, Josephine Park, Hoang Nguyen, Elektra Papadopoulos, Nicole Cooper, Brian Ung, Narae Yun, Teodora P Staeva, Nandan Baruah, Anna Fisch, Lili Garrard, Veronica Vargas Lupo, Judith Mills, Carla Menezes, Jeanine Cox, Carrie Eberspecher, Shanelle Gabriel, Shane Lerner, Malinda Logan, Erika Reyna, Elizabeth Santa Cruz, Veronica Vargas Lupo, Elizabeth Santa Cruz   +28 more
doaj   +1 more source