Results 131 to 140 of about 20,230 (187)
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LUPUS ANTICOAGULANT IN PREGNANCY
The Lancet, 1984summaryIn a group of 10 women with circulating lupus anticoagulant 25 intrauterine deaths were previously documented in the nine multigravidae. The presence of lupus anticoagulant activity was confirmed by showing prolongation of the activated partial thromboplastin time and kaolin clotting time with failure of correction of the prolongation on ...
Prentice, RL +5 more
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Blood Reviews, 1991
Acquired antibodies to phospholipids form a heterogeneous group, which may be detected in vitro by the inhibition of phospholipid dependent tests of coagulation (lupus anticoagulant) and also by immunological assays, such that a combined approach is required for their reliable detection.
M D, Creagh, M, Greaves
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Acquired antibodies to phospholipids form a heterogeneous group, which may be detected in vitro by the inhibition of phospholipid dependent tests of coagulation (lupus anticoagulant) and also by immunological assays, such that a combined approach is required for their reliable detection.
M D, Creagh, M, Greaves
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Arthritis & Rheumatism, 1976
AbstractThe clinical and laboratory experience with the lupus anticoagulant was reviewed in 37 patients. The anticoagulant is thought to act by blocking the activation of prothrombin by the prothrombin activator complex of factors Xa, V, and phospholipid.
M, Boxer, L, Ellman, A, Carvalho
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AbstractThe clinical and laboratory experience with the lupus anticoagulant was reviewed in 37 patients. The anticoagulant is thought to act by blocking the activation of prothrombin by the prothrombin activator complex of factors Xa, V, and phospholipid.
M, Boxer, L, Ellman, A, Carvalho
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Testing for Lupus Anticoagulants
Seminars in Thrombosis and Hemostasis, 2022AbstractLupus anticoagulant (LA) is one of the three criteria antiphospholipid antibodies (aPLs) employed in classification, and by default diagnosis, of antiphospholipid syndrome (APS). Detection of LA is not via calibrated assays but is based on functional behavior of the antibodies in a medley of coagulation assays.
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Standardization of lupus anticoagulant. The Lupus Anticoagulant Sensitivity Index (LASI)
Lupus, 2012Results for lupus anticoagulant (LA) are expressed as ratio of patient-to-normal clotting times (LA-ratio) according to the equation LA-ratio = (Patient Clotting time /Normal Clotting time ).
Tripodi A +2 more
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The challenges of lupus anticoagulants
Expert Review of Hematology, 2016The term "lupus anticoagulant" (LA) refers to a heterogeneous group of immunoglobulins behaving as acquired in vitro inhibitors of coagulation. These antibodies, namely anti-β2GPI and anti-prothrombin antibodies, induce the in vitro elongation of clotting time interfering with phospholipid-dependent coagulation cofactors. Positive LA is associated with
Chighizola, Cecilia Beatrice +5 more
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Lupus Anticoagulant and Stroke
Archives of Neurology, 1987To the Editor. —Tabachnik-Schor and Lipton's 1 recent report of a case of nonvasculitic cerebral infarction associated with a lupuslike anticoagulant (LA) suggests that their case is the first without "other causes of vasculopathy." Several features of their patient's case do not appear to support their conclusion. Their patient's skin biopsy specimen
S R, Levine, K M, Welch
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The Lupus Anticoagulant Paradox
Seminars in Thrombosis and Hemostasis, 2017AbstractLupus anticoagulant (LA) represents the most enigmatic antibody population in patients with antiphospholipid syndrome and represents a paradox that is still unsolved. This class of antiphospholipid antibody causes a phospholipid-dependent prolongation of the clotting time but is associated with an increased risk of thrombosis and pregnancy ...
Jessica E, Molhoek +2 more
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Cofactor of the “Lupus Anticoagulant”
Thrombosis and Haemostasis, 1974SummaryNormal plasma contains an activity known as cofactor which further lengthens the clotting time of the plasma of some patients with the “lupus anticoagulant.55 Cofactor has been characterized as either prothrombin or a gamma globulin. Our findings indicate that cofactor has the following properties: stable at room temperature but largely ...
G E, Rivard, S, Schiffman, S I, Rapaport
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Neurology and the Lupus Anticoagulant
European Neurology, 2008The lupus anticoagulant, an immunoglobulin of the IgG or IgM class, is one of a group of antiphospholipid antibodies. Although an anticoagulant in vitro, its action in vivo is that of a procoagulant. This procoagulant activity may involve many organ systems including the nervous system.
H, Englert, G, Derue, G R, Hughes
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