Lupus anticoagulant - Open Access .click

Results 41 to 50 of about 157,710 (222)

, 2005
Toll-like receptor (TLR)-9 recognizes CpG motifs in microbial DNA. TLR9 signalling stimulates innate antimicrobial immunity and modulates adaptive immune responses including autoimmunity against chromatin, e.g., in systemic lupus erythematosus (SLE ...
Anders, Hans-Joachim, H-J Anders
core +1 more source

Concurrent Acquired Hemophilia A and Lupus Anticoagulant Managed With Emicizumab and Immunosuppression: A Case Report

Case Reports in Hematology
Acquired hemophilia A (AHA) is a rare bleeding disorder that can be accompanied by challenges in diagnosis and management when there is a concurrent lupus anticoagulant.
Julie Williamson +3 more
doaj +1 more source

Spermatic vein thrombosis with lupus anticoagulant, a cause of acute inguinal pain: a case report

The Pan African Medical Journal, 2020
Patients with lupus anticoagulants are at high risk of systemic arterial and venous thrombosis and arterial stroke. We present an unusual case of a young man presenting inguinal pain. Doppler ultrasound revealed spermatic vein thrombosis on the left side.
Mohammed Aynaou +4 more
doaj +1 more source

Extracellular Vesicle Packaged TDP43 Derived From ECs Exacerbates Cigarette Tar‐Related Atherosclerosis Progression via Enhancing Macrophage Extracellular Traps

Advanced Science, EarlyView.
Cigarette tar triggers EC‐derived EVs carrying TDP43, which binds VDAC1 to boost MAMs, mitochondrial Ca2+ overload, and METs formation in macrophages, accelerating smoking‐related AS progression, while retinoic acid binds TDP43 to block this pathogenic cascade.
Xinxin Zhu +20 more
wiley +1 more source

Higher Complement C4 Gene Copy Number Constitutes a Shared Genetic Risk Factor for Giant Cell Arteritis and IgA Vasculitis

Arthritis &Rheumatology, EarlyView.
Objective Low copy number (CN) of complement C4 isoforms and high CN of retroviral HERV‐K elements are known risk factors for many immune‐mediated inflammatory diseases (IMIDs), often showing sex‐biased effects. Here, we assessed whether CN variation within the C4 gene contributes to giant cell arteritis (GCA) and IgA vasculitis (IgAV), two complex ...
Laura Martínez‐Gutiérrez +295 more
wiley +1 more source

Nasal Skin Necrosis: A Very Rare Manifestation of Antiphospholipid Syndrome

European Journal of Case Reports in Internal Medicine, 2017
A 23-year-old woman, a smoker and oral oestrogen user, presented with nasal necrosis. No other symptoms or local trauma were described. Relevant laboratory findings included complement consumption, positive lupus-anticoagulant assay, increased rheumatoid
Carolina Oliveira Ourique +4 more
doaj +1 more source

Clinical significance of antibodies to the phosphatidylserine/prothrombin complex

Современная ревматология, 2022
Classical serological markers of antiphospholipid syndrome (APS) are antibodies to cardiolipin, antibodies to β2-glycoprotein 1, and lupus anticoagulant.
T. M. Reshetnyak +3 more
doaj +1 more source

Significance and Correlation of Lupus Anticoagulant and Anticardiolipin Antibody Assay in High-risk Pregnancy

Journal of Marine Medical Society
Background: Antiphospholipid antibodies (aPL), a heterogeneous group of circulating antibodies including lupus anticoagulant (LAC), anticardiolipin antibodies (aCL), & anti-beta-2-glycoprotein 1 antibodies (aβ2GP1) that have been associated with ...
Blessy Mathew +5 more
doaj +1 more source

Autoimmune hemolytic anemia as an initial presentation in children with systemic lupus erythematosus: two case reports

Journal of International Medical Research, 2022
We report the cases of two children who presented with autoimmune hemolytic anemia (AIHA) as an initial presentation of systemic lupus erythematosus (SLE).
Yan Lu, Xian-Mei Huang
doaj +1 more source

From Interferon Signature to the Clinical Landscape: Type I Interferonopathies

Arthritis &Rheumatology, EarlyView.
Objective TypeI interferonopathies are heterogeneous diseases driven by dysregulated type I interferon (IFN‐I) signaling. Diagnosis is challenging due to clinical/molecular variability and the need for IFN‐I quantification. The aim of this study was to characterize the clinical, immunologic, genetic, molecular profiles of patients with suspected ...
Ismail Yaz +13 more
wiley +1 more source

humans
lupus coagulation inhibitor
3. good health

female
blood coagulation factors
antiphospholipid syndrome

pregnancy
thrombosis
lupus erythematosus, systemic