Results 161 to 170 of about 19,610 (201)

Circulating inhibitors of blood coagulation associated with procainamide‐induced lupus erythematosus

American Journal of Hematology, 1978
AbstractWe studied a patient being treated with procainamide in whom we observed a high antinuclear antibody titer and prolonged activated partial thromboplastin (PTT), prothrombin (PT), and Stypven times (ST). Serum antibody concentrations against single‐stranded DNA were elevated while those against native DNA were not elevated, suggesting the ...
S, Davis, B C, Furie, J H, Griffin, B, Furie, R, Willey   +4 more
openaire   +3 more sources

A Circulating Lupus-like Coagulation Inhibitor Induced by Chlorpromazine

Journal of Clinical Psychopharmacology, 1984
A variety of immune phenomena have been associated with chlorpromazine. One such factor, the lupus-like anticoagulant, while nonspecific, has been reported in 26 to 75% of chronic chlorpromazine recipients, although the exact incidence is unknown and requires further investigation.
G, Tollefson, K, Rodysill, M, Cusulos
openaire   +3 more sources

Acquired Inhibitors of Coagulation in a Patient With Systemic Lupus Erythematosus and Antiphospholipid Antibodies: Response to Rituximab

Reumatología Clínica (English Edition), 2008
Hematologic signs of systemic lupus erythematosus are diverse (SLE). Although a delayed coagulation time is anti-phospholipid antibody related, thrombotic events are the usual clinical manifestation. Spontaneous appearance of circulating anticoagulant in the absence of a previous coagulation disorder is secondary to the development of antibodies to ...
Enrique, Ortiz Jiménez, Sergio, Loera Fragoso, Marina, Rull Gabayet   +2 more
openaire   +3 more sources

Studies on Phospholipids in the Action of a Lupus Coagulation Inhibitor

Pathology, 1975
Plasma from a patient with early manifestations of disseminated lupus erythematosus, a prolonged partial thromboplastin time with kaolin, mildly prolonged prothrombin time, and a circulating inhibitor affecting the assay of several clotting factors was investigated.
T, Exner, K A, Rickard, H, Kronenberg
openaire   +3 more sources

Recurrent Venous Thrombosis with a “Lupus” Coagulation Inhibitor in the Absence of Systemic Lupus

Australian and New Zealand Journal of Medicine, 1977
A young man presenting with recurrent deep venous thrombosis was found to have a lupus type coagulation inhibitor. He showed neither clinical nor serological evidence of systemic lupus. The value of the Russell viper venom coagulation time in the detection of the inhibitor is demonstrated.
A, Manoharan, L, Gibson, B, Rush, B J, Feery   +3 more
openaire   +3 more sources

Natural inhibitors of blood coagulation and fibrinolysis in patients with lupus anticoagulant

Blood Coagulation & Fibrinolysis, 1992
We studied the natural inhibitors (NI) of blood coagulation and fibrinolysis in 50 patients with lupus anticoagulant (LA), in order to identify possible alterations of these NI, that could favour thrombotic manifestations. We found no statistically significant difference in antithrombin III, protein C and alpha 2-antiplasmin between controls and ...
L C, Kordich, R R, Forastiero, E, Basilotta, P, Porterie, L O, Carreras   +4 more
openaire   +3 more sources

Characterization of an acquired IgG inhibitor of coagulation factor XIII in a patient with systemic lupus erythematosus

British Journal of Haematology, 1996
An acquired IgG inhibitor to factor XIII was identified in a 30‐year‐old Vietnamese woman with systemic lupus erythematosus. The IgG fraction was isolated from plasma by chromatography on an agarose gel column and by protein G adsorption. The anti‐factor XIII activity, identified within the IgG fraction, inhibited factor XIII from both normal plasma ...
F, Ahmad, S, Solymoss, M C, Poon, C, Berube, A K, Sullivan   +4 more
openaire   +3 more sources

Changes in Components of the Natural Coagulation Inhibitor System, in Patients with Antiphospholipid Antibodies and/or the Lupus Inhibitor.

Blood, 2006
Abstract The cell surface glycoproteins thrombomodulin (TM) and endothelial protein C receptor (EPCR) are major intermediaries in the down-regulation of thrombin and are noted to be shed from endothelial cells (ECs) due to the actions of proinflammatory cytokines, thrombin and other agents.
Xuam Lam, Jeffrey Birnbaum, Evelyn Y. Ku, De-Hui W. Ku, Yale S. Arkel   +4 more
openaire   +2 more sources

New method to differentiate between lupus anticoagulants, progressive coagulation inhibitors and coagulation factor deficiencies in the mixing tests

International Journal of Laboratory Hematology
AbstractIntroductionMixing tests in activated partial thromboplastin time (APTT) are used for the differentiation between lupus anticoagulants (LA), coagulation inhibitors, and factor deficient samples with APTT prolongation. However, the indexes for the differentiation have not been established.
Daiki Shimomura, Osamu Kumano, Kaori Ueda, Keisuke Kitano, Nobuo Arai, Masashi Shimada, Mikio Kamioka   +6 more
openaire   +3 more sources

LUPUS‐TYPE COAGULATION INHIBITOR IN HAIRY CELL LEUKAEMIA AND REOSOLUTION WITH SPLENECTOMY

British Journal of Haematology, 1987
A. S. Duncombe, R. G. Dalton, G. F. Savidge   +2 more
openaire   +2 more sources