Results 91 to 100 of about 234,888 (250)
Loss of TRIM21 drives UVB‐induced systemic inflammation by regulating DNA‐sensing pathways
Arthritis &Rheumatology, Accepted Article.Background Patients with systemic lupus erythematosus (SLE) experience photosensitivity, with exposure to ultraviolet light B (UVB) driving lupus flares and triggering symptoms like joint pain, fatigue, and cutaneous lesions. Although the mechanism(s) linking UVB exposure to systemic effects are unclear, type I interferons (IFNs) are known to play a ...
Gantsetseg Tumurkhuu +17 more
wiley +1 more source
Arthritis &Rheumatology, EarlyView.Objective Fine particulate matter (PM2.5) is a possible trigger of systemic autoimmune rheumatic diseases (SARDs). We investigated SARDs risk related to long‐term exposure to PM2.5 and its components (ammonium, black carbon, mineral dust, sea salt, nitrate, sulfate, organic matter), the composition of which may affect toxicity.
Mareva Geslin +6 more
wiley +1 more source
Arthritis &Rheumatology, EarlyView.Objective To identify and summarize existing telerehabilitation interventions for people living with rheumatic and musculoskeletal diseases (RMDs), including the rehabilitation components, the technology used, the type of health care professional (HCP) interaction, and how the effectiveness is evaluated.
Thomas A. Ingram +5 more
wiley +1 more source
Arthritis &Rheumatology, Accepted Article.Objective To assess risks of adverse pregnancy outcomes (APO) in a contemporary cohort of women with systemic sclerosis (SSc) in relation to the timing of SSc diagnosis and by parity. Methods From the nationwide Swedish Medical Birth Register, we assembled pregnancies with births in women with SSc and in comparator women from the general population ...
Weng Ian Che +5 more
wiley +1 more source
Arthritis &Rheumatology, Accepted Article.Objective The transition from asymptomatic anti‐nuclear antibody (ANA) positivity to systemic autoimmune rheumatic disease (SARD) is associated with increased production of pro‐inflamamtory factors such as TNF‐α. Here we investigate whether the relative absence of inflammation in asymptomatic ANA+ individuals (ANA+NS) results from a lack of circulating
Carolina Muñoz‐Grajales +8 more
wiley +1 more source
B cells and systemic sclerosis interstitial lung disease
Arthritis &Rheumatology, Accepted Article.Interstitial lung disease is an important complication of systemic sclerosis (SSc‐ILD) with high mortality and morbidity. Recent clinical studies in SSc‐ILD have led to FDA‐approved therapies in SSc‐ILD. Importantly, evidence from these studies has been extrapolated to guide management of interstitial lung diseases of other systemic autoimmune ...
Nina Goldman +2 more
wiley +1 more source
Arthritis &Rheumatology, Accepted Article.Objective International criteria for antiphospholipid syndrome (APS) include lupus anticoagulant (LA), anticardiolipin (aCL) immunoglobulin (Ig) G and IgM, and anti‐β2‐glycoprotein I (β2GPI) IgG and IgM. However, evidence supporting their prognostic value or treatment efficacy in improving live birth rates is limited.
Megumi Nonobe +8 more
wiley +1 more source
Serum cytokine profiling differentiates underlying diseases in cytokine storm syndrome
Arthritis &Rheumatology, Accepted Article.Objective Cytokine storm syndrome (CSS), commonly associated with hemophagocytic lymphohistiocytosis (HLH), is a fatal hyperinflammatory syndrome. Differentiating the underlying diseases responsible for CSS is essential for timely therapeutic decisions. This study explored the clinical usefulness of serum cytokine profiling in distinguishing underlying
Shuya Kaneko +42 more
wiley +1 more source
Arthritis &Rheumatology, Accepted Article.Objective Keratinocyte‐derived interferon kappa (IFN‐κ) is chronically overexpressed in human non‐lesional systemic lupus erythematosus (SLE) skin. Recent evidence suggests that epidermal signals instruct the immune system in SLE, but whether epidermal IFN‐κ alone is sufficient to drive lupus phenotypes has not been investigated.
Benjamin Klein +14 more
wiley +1 more source