Results 41 to 50 of about 390,856 (338)
Trial of Anifrolumab in Active Systemic Lupus Erythematosus.
New England Journal of Medicine, 2019 BACKGROUND Anifrolumab, a human monoclonal antibody to type I interferon receptor subunit 1 investigated for the treatment of systemic lupus erythematosus (SLE), did not have a significant effect on the primary end point in a previous phase 3 trial.
E. Morand +10 more
semanticscholar +1 more source
Targeting CD38 with Daratumumab in Refractory Systemic Lupus Erythematosus.
New England Journal of Medicine, 2020 Daratumumab, a human monoclonal antibody that targets CD38, depletes plasma cells and is approved for the treatment of multiple myeloma. Long-lived plasma cells are implicated in the pathogenesis of systemic lupus erythematosus because they secrete ...
L. Ostendorf +16 more
semanticscholar +1 more source
The significance of M1/M2 macrophage-like monocytes in children with systemic lupus erythematosus
European Journal of Inflammation, 2019 Monocytes/macrophages are important in the development of systemic lupus erythematosus. To research M1 and M2 macrophage-like monocytes in the peripheral blood of children with systemic lupus erythematosus and explore the clinical significance, M1 and M2
Xiao-Ling Niu +6 more
doaj +1 more source
BMC Musculoskeletal Disorders, 2004 Background Systemic lupus erythematosus is an age- and gender-associated autoimmune disorder. Previous studies suggested that defects in the hypothalamic/pituitary axis contributed to systemic lupus erythematosus disease progression which could also ...
Malemud Charles J, Denko Charles W
doaj +1 more source
Journal of Translational Autoimmunity, 2020 Neuropsychiatric systemic lupus erythematosus is an autoimmune disorder characterized by an irregular exchange between the central nervous system and the immune system, leading to the outbreak of neurological conditions with possible disabling effects ...
Sangita Khatri +7 more
doaj +1 more source
Role of brain perfusion SPECT with 99mTc HMPAO in the assessment of response to drug therapy in patients with autoimmune vasculitis: a prospective study [PDF]
, 2015 BACKGROUND: The diagnosis of vasculitis in the brain remains a quite difficult achievement. To the best of our knowledge, there is no imaging method reported in literature which is capable of reaching to a diagnosis of vasculitis with very high ...
Anna Margherita Maffione, 2 +11 more
core +1 more source
Toll-like receptor signalling in B cells during systemic lupus erythematosus
Nature Reviews Rheumatology, 2020 B lymphocytes have a central role in autoimmune diseases, which are often defined by specific autoantibody patterns and feature a loss of B cell tolerance.
S. Fillatreau, B. Manfroi, T. Dörner
semanticscholar +1 more source
Macrophage Activation Syndrome as Onset of Systemic Lupus Erythematosus: A Case Report and a Review of the Literature [PDF]
, 2015 Macrophage activation syndrome (MAS) is a potentially fatal condition. It is a rare complication of several autoimmune disorders, including systemic lupus erythematosus (SLE) and systemic juvenile idiopathic arthritis (sJIA).
Didona, Dario +4 more
core +4 more sources
American Journal of Ophthalmology Case Reports, 2018 Purpose: To describe a triad of fibrous histiocytoma, Systemic Lupus Erythematosus and Sero-positive Sjögren's Syndrome. Observations: This case was diagnosed first as bilateral fibrous histiocytoma of cheeks, which on further investigations proved to be
Abdullah Al-Mujaini +2 more
doaj +1 more source
Systemic 5-fluorouracil induced lupus erythematosus: a review of the literature [PDF]
, 2019 Drug-induced subacute cutaneous lupus erythematosus (SCLE) is the most common subtype of drug-induced systemic lupus erythematosus and has been associated with more than 100 drugs.
Marsch, Amanda F, Shakhbazova, Anastasia
core