Results 41 to 50 of about 268,948 (265)

Anti-dsDNA negative and anti-Ro positive lupus nephritis: a report of a rare case

Reumatismo, 2014
Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease, characterized by an autoantibody response to various nuclear and cytoplasmic antigens.
D. Jain, H.K. Aggarwal, V. Kaverappa, S. Dhayia, P. Jain, S. Yadav   +5 more
doaj   +1 more source

Expanding the Role of Complement Therapies: The Case for Lupus Nephritis

Journal of Clinical Medicine, 2021
The complement system is an innate immune surveillance network that provides defense against microorganisms and clearance of immune complexes and cellular debris and bridges innate and adaptive immunity.
Nicholas L. Li, D. Birmingham, B. Rovin
semanticscholar   +1 more source

The Pathogenesis of Lupus Nephritis [PDF]

Journal of the American Society of Nephrology, 2013
Lupus nephritis is an immune complex GN that develops as a frequent complication of SLE. The pathogenesis of lupus nephritis involves a variety of pathogenic mechanisms. The extrarenal etiology of systemic lupus is based on multiple combinations of genetic variants that compromise those mechanisms normally assuring immune tolerance to nuclear ...
Maciej, Lech, Hans-Joachim, Anders
openaire   +2 more sources

Long Non-Coding RNA TUG1 Gene Polymorphism and TUG1 Expression Level as Molecular Biomarkers of Systemic Lupus Erythematosus and Lupus Nephritis

Non-Coding RNA, 2023
Long non-coding RNA (lncRNA) TUG1 acts as a proto-oncogene, allowing the proliferation of tumor cells, and it has been related to inflammation. Therefore, we aimed in this study to investigate for the first time the role of TUG1 gene polymorphism and the
Gehan Abd-Elfatah Tawfeek, Heba Kasem, Eman Ali Abdallah, Mohammed Almulhim, Abdullah Almulhim, Mohammed Albarqi, Khaled Mohamed Amin Elzorkany   +6 more
doaj   +1 more source

Immunophenotyping identifies distinct cellular signatures for systemic lupus erythematosus and lupus nephritis

Rheumatology & Autoimmunity, 2023
Background Systemic lupus erythematosus (SLE) is a complex systemic autoimmune disease characterized by development of autoantibodies and multiorgan involvement. Kidney involvement, termed lupus nephritis, has major impact on life expectancy.
Yi Tong V. Aw, Phillip J. Whiley, Ayla May Lorenzo, Tom Lea‐Henry, Somasundhari Shanmuganandam, Maurice Stanley, Sonia N. Babu, Vicki Athanasopoulos, Jean Cappello, Julia I. Ellyard, Matthew Cook, Carola Vinuesa, Giles Walters, David A. Fulcher, Simon H. Jiang   +14 more
doaj   +1 more source

The immune cell landscape in kidneys of patients with lupus nephritis

Nature Immunology, 2019
Lupus nephritis is a potentially fatal autoimmune disease for which the current treatment is ineffective and often toxic. To develop mechanistic hypotheses of disease, we analyzed kidney samples from patients with lupus nephritis and from healthy control
A. Arazi, Deepak A. Rao, C. Berthier, A. Davidson, Yanyan Liu, P. Hoover, A. Chicoine, T. Eisenhaure, A. Jonsson, Shuqiang Li, David J. Lieb, Fan Zhang, Kamil Slowikowski, E. Browne, A. Noma, Danielle Sutherby, S. Steelman, D. Smilek, Patti Tosta, W. Apruzzese, E. Massarotti, M. Dall'Era, Meyeon Park, D. Kamen, R. Furie, F. Payan-Schober, W. Pendergraft, E. McInnis, J. Buyon, M. Petri, C. Putterman, K. Kalunian, E. Woodle, J. Lederer, David A Hildeman, C. Nusbaum, S. Raychaudhuri, M. Kretzler, J. Anolik, M. Brenner, D. Wofsy, N. Hacohen, B. Diamond   +42 more
semanticscholar   +1 more source

Lupus nephritis: clinical presentations and outcomes in the 21st century

Rheumatology, 2020
Lupus nephritis (LN) is a frequent and severe manifestation of SLE. Along the decades, the epidemiology of LN and its clinical presentation have been changing.
M. Gasparotto, M. Gatto, V. Binda, A. Doria, G. Moroni   +4 more
semanticscholar   +1 more source

Lupus nephritis

Kidney International, 1997
Contains fulltext : 24337___.PDF (Publisher’s version ) (Open Access)
openaire   +3 more sources

Neutrophil gelatinase-associated lipocalin is a urine-based biomarker for diagnosing active lupus nephritis

Bangabandhu Sheikh Mujib Medical University Journal
Background: Lupus nephritis is one of the most serious complications of systemic lupus erythematosus (SLE). Urinary neutrophil gelatinase-associated lipocalin (NGAL) is a non-invasive biomarker that may aid in diagnosing active lupus nephritis.
Anthony Chakma, Debatosh Paul, Sheuly Ferdoushi, Minhaj Rahim Choudhury, Md. Saiful Islam   +4 more
doaj   +1 more source

CALIBRATE: A Phase 2 Randomized Trial of Rituximab Plus Cyclophosphamide Followed by Belimumab for the Treatment of Lupus Nephritis

Arthritis & Rheumatology, 2020
To assess the safety, mechanism of action, and preliminary efficacy of rituximab followed by belimumab in the treatment of refractory lupus nephritis (LN).
Y. Atisha-Fregoso, S. Malkiel, Kristina M. Harris, M. Byron, Linna Ding, S. Kanaparthi, William T. Barry, Wendy Gao, Kristin Ryker, Patti Tosta, A. Askanase, S. Boackle, W. Chatham, D. Kamen, David Karp, K. Kirou, S. Sam Lim, B. Marder, M. McMahon, Samir V. Parikh, W. Pendergraft, Amber S. Podoll, A. Saxena, D. Wofsy, B. Diamond, Dawn E. Smilek, C. Aranow, M. Dall'Era   +27 more
semanticscholar   +1 more source