Results 21 to 30 of about 109,330 (215)
Renal Dnase1 enzyme activity and protein expression is selectively shut down in murine and human membranoproliferative lupus nephritis. [PDF]
PLoS ONE, 2010 BACKGROUND: Deposition of chromatin-IgG complexes within glomerular membranes is a key event in the pathogenesis of lupus nephritis. We recently reported an acquired loss of renal Dnase1 expression linked to transformation from mild to severe ...
Svetlana N Zykova +2 more
doaj +1 more source
Anti-dsDNA negative and anti-Ro positive lupus nephritis: a report of a rare case
Reumatismo, 2014 Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease, characterized by an autoantibody response to various nuclear and cytoplasmic antigens.
D. Jain +5 more
doaj +1 more source
Biomedicines, 2023 Lupus nephritis (LN) is one of the most common and serious complications of systemic lupus erythematosus (SLE). The risk factors for developing LN by SLE patients are not fully understood. They are considered to be a mix of genetic and environmental variables, one of them being dysbiosis, proposed recently to interfere with autoimmunity. As of yet, the
Marta Monticolo +2 more
openaire +3 more sources
Does Rheumatoid Factor have any Protective Role in Patients with Lupus Nephritis [PDF]
Al-Anbar Medical Journal, 2020 Background: Systemic lupus erythematosus (SLE) is a chronic inflammatory disease that appears to result from an immune-regulatory disturbance caused by an interplay of genetic, hormonal, immunological, and environmental factors.
Khamis Y. C. AL-Qubaeissy +3 more
doaj +1 more source
Mediators of Inflammation, 2023 Objective. Modified C-reactive protein (mCRP) is known to be involved in the upregulation and amplification of the local inflammatory response. This study investigated the circulating and local levels of mCRP and their relevance to clinicopathological ...
Mo Yuan +4 more
doaj +1 more source
Distinct pathogenic roles for resident and monocyte-derived macrophages in lupus nephritis
JCI Insight, 2023 Lupus nephritis is a serious complication of systemic lupus erythematosus, mediated by IgG immune complex (IC) deposition in kidneys, with limited treatment options. Kidney macrophages are critical tissue sentinels that express IgG-binding Fcγ receptors (
Nathan Richoz +14 more
doaj +1 more source
FCGR3B copy number variation is associated with systemic lupus erythematosus risk in Afro-Caribbeans. [PDF]
, 2011 OBJECTIVES: To evaluate FCGR3B copy number variation (CNV) in African and European populations and to determine if FCGR3B copy number is associated with SLE and SLE nephritis risk in Afro-Caribbeans, adjusting for African genetic ancestry.
A. L. Patrick +21 more
core +1 more source
Non-Coding RNA, 2023 Long non-coding RNA (lncRNA) TUG1 acts as a proto-oncogene, allowing the proliferation of tumor cells, and it has been related to inflammation. Therefore, we aimed in this study to investigate for the first time the role of TUG1 gene polymorphism and the
Gehan Abd-Elfatah Tawfeek +6 more
doaj +1 more source
The Pathogenesis of Lupus Nephritis [PDF]
Journal of the American Society of Nephrology, 2013 Lupus nephritis is an immune complex GN that develops as a frequent complication of SLE. The pathogenesis of lupus nephritis involves a variety of pathogenic mechanisms. The extrarenal etiology of systemic lupus is based on multiple combinations of genetic variants that compromise those mechanisms normally assuring immune tolerance to nuclear ...
Maciej, Lech, Hans-Joachim, Anders
openaire +2 more sources
Early Discoid Lupus Erythematosus Protects Against Renal Disease In Patients With Systemic Lupus Erythematosus: Longitudinal Data From A Large Latin American Cohort [PDF]
, 2017 The objective of this study was to examine whether early discoid lupus erythematosus (DLE) would be a protective factor for further lupus nephritis in patients with systemic lupus erythematosus (SLE).
V.; Alvarellos +19 more
core +3 more sources