Results 21 to 30 of about 268,948 (265)

A secondary analysis of the Belimumab International Study in Lupus Nephritis trial examined effects of belimumab on kidney outcomes and preservation of kidney function in patients with lupus nephritis.

Kidney International, 2021
We performed a post hoc analysis of the Belimumab International Study in Lupus Nephritis (BLISS-LN), a Phase 3, multinational, double-blind, 104-week trial, in which 448 patients with lupus nephritis were randomized to receive intravenous belimumab 10 mg/
B. Rovin, R. Furie, Y. Teng, G. Contreras, A. Malvar, Xueqing Yu, B. Ji, Y. Green, T. González-Rivera, D. Bass, J. Gilbride, Chun-Hang Tang, D. Roth   +12 more
semanticscholar   +1 more source

Comparison of clinical features and outcomes between patients with early and delayed lupus nephritis

BMC Nephrology, 2020
Background Lupus nephritis is associated with increased risk of end-stage renal disease (ESRD) and all-cause mortality. We evaluated the clinical features and outcomes of patients with early and delayed lupus nephritis. Methods The medical records of 171
Sung Soo Ahn, Juyoung Yoo, Seung Min Jung, Jason Jungsik Song, Yong-Beom Park, Sang-Won Lee   +5 more
doaj   +1 more source

Kidney tubular epithelial cell ferroptosis links glomerular injury to tubulointerstitial pathology in lupus nephritis

Clinical Immunology, 2022
Ferroptosis is a druggable, iron-dependent form of cell death that is characterized by lipid peroxidation but has received little attention in lupus nephritis. Kidneys of lupus nephritis patients and mice showed increased lipid peroxidation mainly in the
A. Alli, Dhruv P. Desai, Ahmed Elshika, M. Conrad, B. Proneth, W. Clapp, Carl Atkinson, M. Segal, L. Searcy, N. Denslow, Subhashini Bolisetty, B. Mehrad, L. Morel, Y. Scindia   +13 more
semanticscholar   +1 more source

Molecular signatures of intrarenal complement receptors C3AR1 and C5AR1 correlate with renal outcome in human lupus nephritis

Lupus Science and Medicine, 2022
Objective Lupus nephritis is one of the most common and serious complications of systemic lupus erythematosus (SLE). Lupus nephritis is a major cause of kidney failure in patients with SLE, attributed to increased morbidity and mortality.
Samy Hakroush, Björn Tampe, Desiree Tampe   +2 more
doaj   +1 more source

CD36 aggravates podocyte injury by activating NLRP3 inflammasome and inhibiting autophagy in lupus nephritis

Cell Death and Disease, 2022
A major cause of proteinuria in lupus nephritis (LN) is podocyte injury, and determining potential therapeutic targets to prevent podocyte injury is important from a clinical perspective in the treatment of LN.
Fu Lv, Ying-jie He, Hongde Xu, Yongchun Li, Li-pei Han, Lijie Yan, H. Lang, Yafei Zhao, Zhanzheng Zhao, Yu-feng Qi   +9 more
semanticscholar   +1 more source

Incidence, Prevalence, and Mortality of Lupus Nephritis: A Population-Based Study Over Four Decades—The Lupus Midwest Network (LUMEN)

Arthritis & Rheumatology, 2022
There is a paucity of population‐based studies investigating the epidemiology of lupus nephritis (LN) in the US and long‐term secular trends of the disease and its outcomes.
M. Hocaoğlu, M. Valenzuela-Almada, Jesse Y Dabit, S. Osei-Onomah, B. Chevet, R. Giblon, L. Zand, F. Fervenza, C. Helmick, C. Crowson, A. Duarte-García   +10 more
semanticscholar   +1 more source

The Role of Anti-mCRP Autoantibodies in Lupus Nephritis

Kidney Diseases, 2023
Background: Lupus nephritis is characterized by multiple autoantibodies production. However, there are few autoantibodies associated with disease activity and prognosis.
Mo Yuan, Ying Tan, Ming-hui Zhao
doaj   +1 more source

Two-Year, Randomized, Controlled Trial of Belimumab in Lupus Nephritis.

New England Journal of Medicine, 2020
BACKGROUND In adults with active lupus nephritis, the efficacy and safety of intravenous belimumab as compared with placebo, when added to standard therapy (mycophenolate mofetil or cyclophosphamide-azathioprine), are unknown.
R. Furie, B. Rovin, F. Houssiau, A. Malvar, Y. Teng, G. Contreras, Z. Amoura, Xueqing Yu, C. Mok, M. Santiago, A. Saxena, Y. Green, B. Ji, C. Kleoudis, S. Burriss, Carly R. Barnett, D. Roth   +16 more
semanticscholar   +1 more source

Association of STAT4 polymorphism with severe renal insufficiency in lupus nephritis. [PDF]

PLoS ONE, 2013
Lupus nephritis is a cause of significant morbidity in systemic lupus erythematosus (SLE) and its genetic background has not been completely clarified.
Karin Bolin, Johanna K Sandling, Agneta Zickert, Andreas Jönsen, Christopher Sjöwall, Elisabet Svenungsson, Anders A Bengtsson, Maija-Leena Eloranta, Lars Rönnblom, Ann-Christine Syvänen, Iva Gunnarsson, Gunnel Nordmark   +11 more
doaj   +1 more source

In Patients with Membranous Lupus Nephritis, Exostosin-Positivity and Exostosin-Negativity Represent Two Different Phenotypes.

Journal of the American Society of Nephrology, 2021
BACKGROUND In patients with secondary (autoimmune) membranous nephropathy, two novel proteins, Exostosin 1 and Exostosin 2 (EXT1/EXT2), are potential disease antigens, biomarkers, or both.
A. Ravindran, M. Casal Moura, F. Fervenza, S. Nasr, M. Alexander, M. Fidler, Loren P. Herrera hernandez, Pingchuan Zhang, J. Grande, L. Cornell, Louann Gross, V. Negron, Grace E Jenson, B. Madden, M. Charlesworth, S. Sethi   +15 more
semanticscholar   +1 more source