Results 61 to 70 of about 295,397 (306)

Tratamento da nefrite lúpica.

Acta Médica Portuguesa, 2008
Systemic lupus erithematosus (SLE) is a multiorganic inflammatory disease characterized by a significant morbidity and mortality related not just to disease evolution but also to therapeutic side effects.
Carla Santos-Araújo, Manuel Pestana
doaj   +1 more source

Urine peptidomic biomarkers for diagnosis of patients with systematic lupus erythematosus [PDF]

, 2018
Background: Systematic lupus erythematosus (SLE) is characterized with various complications which can cause serious organ damage in the human body. Despite the significant improvements in disease management of SLE patients, the non-invasive diagnosis ...
Burkly, L.C., Mischak, H., Mullen, W., Pejchinovski, M., Petri, M.A., Siwy, J., Wei, R.   +6 more
core   +1 more source

Hydroxychloroquine Associated With Lower Glomerular Filtration Rate Decline in Lupus Nephritis

Arthritis Care &Research, EarlyView.
Objective Hydroxychloroquine (HCQ) protects kidney function in lupus nephritis (LN) by preventing flares, yet some cohort studies show no significant benefit in kidney function with HCQ. Clarifying these conflicting findings by showing early and long‐term benefits of HCQ on kidney function preservation is critical.
Shivani Garg, Brad Rovin, Brad C. Astor, Tripti Singh, Fauzia Hollnagel, Megan Kuik, Lexie Kolton, Callie Saric, S. Sam Lim, Christie M. Bartels   +9 more
wiley   +1 more source

High prevalence of anti-C1q antibodies in biopsy-proven active lupus nephritis [PDF]

, 2017
Background. Anti-C1q antibodies (anti-C1q) have been shown to correlate positively with systemic lupus erythematosus (SLE) nephritis. Several clinical studies indicated a high negative predictive value, suggesting that active lupus nephritis is rarely ...
Frémeaux-Bacchi, Véronique, Honsova, Eva, Jancova, Eva, Lopez-Trascasa, Margarita, Martinez-Ara, Jorge, Moll, Solange, Picazo, Mari Luz, Potlukova, Eliska, Regenass, Stephan, Sadallah, Salima, Schifferli, Jürg, Tesar, Vladimir, Trendelenburg, Marten   +12 more
core  

Kidney disease in lupus is not always 'lupus nephritis' [PDF]

, 2013
In lupus erythematosus, elevated serum creatinine levels and urinary abnormalities implicate a kidney disorder, which may not always be lupus nephritis as defined by the current classification of the International Society of Nephrology/Renal Pathology ...
A Rahman, D Song, Hans-Joachim Anders, HJ Anders, Jan J Weening, JJ Weening   +5 more
core   +5 more sources

Cellular aspects of the pathogenesis of lupus nephritis

Current Opinion in Rheumatology, 2020
Purpose of review Lupus nephritis is a common severe manifestation of systemic lupus erythematosus. Despite recent advances in therapeutics and understanding of its pathogenesis, there are still substantial unmet needs.
A. Chang, M. Clark, K. Ko
semanticscholar   +1 more source

Identifying High‐Impact Solutions to Address Racial and Ethnic Health Disparities in Lupus: A Consensus‐Based Approach

Arthritis Care &Research, EarlyView.
Objective We conducted formative research aimed at identifying solutions that address inequitable health outcomes in lupus due to adverse social determinants of health (SDoH). Methods We conducted a search for keywords, which provided insights into potential solutions and initiatives underway. An advisory panel of lupus experts iteratively reviewed the
Joy Buie, Michael P. Fisher, Kristen Backor, Hannah Tyldsley, Ashira Blazer, Candace Feldman, Andrea Knight, S. Sam Lim, Barbara Ann Polk, Ed Yelin, Edith Williams, Karen H. Costenbader   +11 more
wiley   +1 more source

Therapeutically targeting proinflammatory type I interferons in systemic lupus erythematosus: efficacy and insufficiency with a specific focus on lupus nephritis

Frontiers in Immunology
Type I interferons (IFN-Is) are important players in the immunopathogenesis of systemic lupus erythematosus (SLE). Pathogenic events in patients with SLE are potent triggers of IFN-I induction, yet IFN-I may induce or initiate the immunopathogenesis ...
Benjamin Lai, Shue-Fen Luo, Jenn-Haung Lai, Jenn-Haung Lai   +3 more
doaj   +1 more source

Arginine mutation alters binding of a human monoclonal antibody to antigens linked to systemic lupus erythematosus and the antiphospholipid syndrome [PDF]

, 2007
Objective: Previous studies have shown the importance of somatic mutations and arginine residues in the complementarity-determining regions (CDRs) of pathogenic anti-double-stranded DNA (anti-dsDNA) antibodies in human and murine lupus, and in studies of
Giles, I., Ioannou, Y., Isenberg, D.A., Lambrianides, A., Latchman, D.S., Manson, J.J., Mason, L., Rahman, A.   +7 more
core   +1 more source

Prevalence, Determinants, and Outcomes of Low Disease Activity and Remission Attainment in Patients With Systemic Lupus Erythematosus That Is Clinically Active

Arthritis Care &Research, EarlyView.
Objective This study aimed to identify in patients with systemic lupus erythematosus (SLE) with clinically active disease the attainment of frequency and determinants of Lupus Low Disease Activity State (LLDAS) and Definition of Remission in SLE (DORIS) and the frequency and determinants of flare and damage accrual after target attainment.
Yanjie Hao, Dylan Hansen, Rangi Kandane‐Rathnayake, Worawit Louthrenoo, Yi‐Hsing Chen, Jiacai Cho, Aisha Lateef, Laniyati Hamijoyo, Shue Fen Luo, Yeong‐Jian Jan Wu, Sandra Navarra, Leonid Zamora, Zhanguo Li, Sargunan Sockalingam, Yasuhiro Katsumata, Masayoshi Harigai, Zhuoli Zhang, Madelynn Chan, Jun Kikuchi, Tsutomu Takeuchi, Sang‐Cheol Bae, Fiona Goldblatt, Sean O'Neill, Kristine (Pek Ling) Ng, Annie Law, B. M. D. B. Basnayake, Nicola Tugnet, Sunil Kumar, Cherica Tee, Michael Tee, Naoaki Ohkubo, Yoshiya Tanaka, Shirley Chan, C. S. Lau, Vera Golder, Alberta Hoi, Shereen Oon, Eric Morand, Mandana Nikpour, for the Asia‐Pacific Lupus Collaboration   +39 more
wiley   +1 more source