Results 131 to 140 of about 108,236 (258)

Ligand binding represses bacterial histidine kinase activity by inhibiting its dimerization

The FEBS Journal, EarlyView.
PdtaS is a kinase in the pathogen Mycobacterium tuberculosis that senses copper and nitric oxide and controls virulence gene expression, but how the kinase senses these compounds was unclear. We show that PdtaS is active as a dimer with each monomer phosphorylating the other in trans.
Gaurav D. Sankhe, Jiawei Xing, Xiansha Xiao, John A. Buglino, Huilin Li, Igor B. Zhulin, Michael S. Glickman   +6 more
wiley   +1 more source

Neonatal sepsis in Cameroon: A call for a national registry and surveillance to bridge data and action gaps. [PDF]

New Microbes New Infect
Founou LL, Founou RC.
europepmc   +1 more source

Conserved dimerization architecture in C‐type lectins from virus‐vector mosquitoes

The FEBS Journal, EarlyView.
C‐type lectins (CTLs) are involved in the detection of viral/microbial carbohydrates. We studied a family of soluble CTLs in the mosquito Aedes aegypti, which acts as a vector for viruses like dengue and Zika. Using crystallography, biophysics, and structure prediction approaches, we found that these proteins consistently pair together in the same ...
Mattia Bertinelli, Rupesh Balaji Jayachandran, Jack Whitehead, Cédric Leyrat, Annabel v. Clanner, Guido C Paesen, Max Renner   +6 more
wiley   +1 more source

Working memory's pointer system is governed by physical objecthood, not spatiotemporal information. [PDF]

Psychon Bull Rev
Balaban H.
europepmc   +1 more source

Structural insights into xyloglucan recognition by an ABC transporter from a Gram‐positive, thermophilic bacterium

The FEBS Journal, EarlyView.
Athe_2052 is an ABC transporter substrate‐binding protein that recognizes xyloglucan heptasaccharide (XXXG), a soluble breakdown product of plant xyloglucan. The crystal structure of Athe_2052, together with binding assays and computational modeling, shows how XXXG is recognized by this sugar transporter.
Hansen Tjo, Virginia Jiang, Philip D. Jeffrey, Angela Zhu, A. James Link, Jerelle A. Joseph, Jonathan M. Conway   +6 more
wiley   +1 more source

The Enduring Relevance of "Romantic Neuroscience" in Biological Psychiatry. [PDF]

Indian J Psychol Med
Uvais NA, Rahman AMAU.
europepmc   +1 more source

Alternative [2Fe‐2S] donor assemblies in the cytosol: GLRX3 and GLRX3‐BOLA2 converge on NUBP1 maturation

The FEBS Journal, EarlyView.
GLRX3 homodimer and GLRX3‐BOLA2 heterotrimer act as alternative [2Fe‐2S] donor assemblies for NUBP1 maturation. Both systems support formation of [4Fe‐4S] cluster‐bound NUBP1, but display distinct kinetic dependence on the physiological electron donor anamorsin, which accelerates GLRX3‐mediated transfer but does not enhance GLRX3‐BOLA2‐mediated ...
Martina Masini, Rosanna Cuccaro, Lucia Banci   +2 more
wiley   +1 more source

Complete genome sequences of <i>Staphylococcus aureus</i> isolates with a novel sequence type from a patient with hospital-acquired pneumonia. [PDF]

Microbiol Resour Announc
Amusin DB, Nozick SH, Wunderink RG, Ozer EA, Hauser AR.   +4 more
europepmc   +1 more source

Directional information flow in human frataxin defines allosteric pathways connecting the hydrophobic core to the iron‐binding ridge

The FEBS Journal, EarlyView.
Human frataxin deficiency causes Friedreich's ataxia, yet how iron‐binding events are communicated across the protein is unclear. Using transfer entropy analysis of molecular dynamics simulations, we identify buried hydrophobic core leucines (LEU136, LEU140) as the source of directional signaling toward the iron‐binding acidic ridge.
Kevser Kübra Kırboğa, Ecir Uğur Küçüksille   +1 more
wiley   +1 more source

New methods drive new biology. [PDF]

Genetics
Lohse K, Fields S, Chikina M.
europepmc   +1 more source