Results 151 to 160 of about 106,151 (254)

Engineering a Synthetic Formatotrophic Yeast With Enhanced Growth Capacity on Formate

Advanced Energy and Sustainability Research, Volume 7, Issue 5, May 2026.
Engineering Yeast for Growth on Formate and Methanol via Serine‐Centered C1 Coupling. By engineering serine metabolism and remodeling the rGly pathway, we rendered yeast growth strictly dependent on formate. This synthetic formatotrophy enables growth on dual‐C1 substrates by channeling formate into the central metabolism via serine deaminases and ...
Shuyuan Guo, Gulikezi Maimaitirexiati, Qiannan Zhang, Zhehao Jin, Kaidi Chen, Tiantian Zou, Xuemei Zhao, Xiangjian Liu, Zhenmin Bai, Dashuang Gao, Xudong Kong, Tao Yu   +11 more
wiley   +1 more source

Systemic neuropsychology: toward a contemporary theory of topological functional systems. [PDF]

Front Psychiatry
Guiral JA.
europepmc   +1 more source

Digital seed amplification assay for TDP‐43 aggregate quantification in CSF

Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.
Abstract INTRODUCTION Dementia is commonly caused by underlying pathologies driven by misfolded protein aggregates. Although dementia subtypes have distinct mechanisms, overlapping symptoms make diagnosis without biomarkers difficult. Misdiagnosis has previously hindered drug development by enrolling patients non‐specifically in trials.
Ella Borberg, Zoe Swank, Tal Gilboa, Lily A. Wickland Shearer, Arek V. Melkonian, Justin C. Rolando, David R. Walt, Andrew M. Stern   +7 more
wiley   +1 more source

Mutation rate variability in viral populations: Implications for lethal mutagenesis. [PDF]

Proc Natl Acad Sci U S A
Arcos S, Lauring AS.
europepmc   +1 more source

Enhanced Sensitivity of a Modified Quaking‐Induced Conversion Diagnostic Test for the Broad Detection of Sporadic and Inherited Prion Diseases: A Retrospective Study

Annals of Neurology, Volume 99, Issue 5, Page 1303-1314, May 2026.
Objective Quaking‐induced conversion (QuIC) tests, which detect prion‐seeding activity in cerebrospinal fluid (CSF), have markedly advanced the antemortem diagnosis of prion diseases such as Creutzfeldt‐Jakob disease (CJD). These tests provide high diagnostic accuracy and enable timely differentiation from other rapidly progressive neurodegenerative ...
Jennifer Myskiw, Rebecca Fox, Dominic M.S. Kielich, Lise Lamoureux, Melanie Leonhardt, Olivia Nykvist, Jessy A. Slota, Kristen Avery, Clark Phillipson, Kathy Frost, Sharon Simon, Brian S. Appleby, Ben A. Bailey‐Elkin, Stephanie A. Booth   +13 more
wiley   +1 more source

Equity-focused implementation to enhance access to rare disease genomic research and understand diverse perspectives. [PDF]

Genet Med
Martinez E, Serrano J, Abouhala S, Neale A, VanNoy G, Rehm HL, O'Leary M, O'Donnell-Luria A, Wojcik MH.   +8 more
europepmc   +1 more source

Recombinant Fibrinogen‐Gamma‐Chain as a Crosslinker of Thiol‐ene Hydrogels

Biopolymers, Volume 117, Issue 3, May 2026.
Fibrinogen gamma chain (FGG) was recombinantly expressed in E. coli to generate a recombinant protein containing free thiol groups from cysteine. The expressed protein was used to crosslink norbornene functionalized gelatin providing a proof‐of‐principle of this novel crosslinker type and the formed hydrogels were characterized for their stiffness ...
Domenic Schlauch, Charlotte Selin Güler, Marina Harzi, Selin Kara, Antonina Lavrentieva, Iliyana Pepelanova   +5 more
wiley   +1 more source

Socioeconomic disparities and severity of gunshot injuries in Israel: a retrospective review of National Trauma Registry data from public hospitals 2019-2022. [PDF]

Inj Epidemiol
Awwad A, Abo Naser L, Ziv A, Givon A, Wolf JM, Strelzow JA, Farhat E, Luria S, Israel Trauma Group.   +8 more
europepmc   +1 more source

Outer Membrane Vesicles Mediate the Secretion and Nuclear Trafficking of a Bacterial Nucleomodulin

Journal of Extracellular Vesicles, Volume 15, Issue 5, May 2026.
(A) We propose that Helicobacter pylori secretes a nucleomodulin, Tumour Necrosis Factor‐α‐inducing protein (Tipα), predominantly via extracellular vesicles (EVs), also known as outer membrane vesicles, rather than as free protein. (B) EVs carrying Tipα enter eukaryotic cells by endocytosis and independently of surface‐expressed nucleolin, then traffic
Jack K. Emery, Variya Nemidkanam, Nina Colon, Kate R. J. Friesen, Lena H. M. Le, Angus R. Cramond, Maxine Yap, Mônica S. Barbosa, Georgie Wray‐McCann, David J. McGee, Natalia Castaño‐Rodríguez, Dongmei Tong, Caroline Skene, Laurent Terradot, Richard L. Ferrero   +14 more
wiley   +1 more source

Mentorship, memory, and honor: Rita Levi-Montalcini's legacy and the role of academic recognition in promoting women in science. [PDF]

Front Mol Neurosci
Sun L, Delouya G, Taussky D.
europepmc   +1 more source