Results 171 to 180 of about 108,236 (258)

Sodium Channel Blockers Demonstrate Binding Affinity for the Tandem Tudor Domain of the Epigenetic Hub UHRF1

ChemMedChem, Volume 21, Issue 17, 14 September 2026.
An investigation of the tandem Tudor domain (TTD) domain of UHRF1 identified and extensively characterized the local anesthetic hydroxyprocaine as a strong ligand capable of activating related genes such as p53 and also highlighted a new, potentially druggable intramolecular interaction between TTD and UBL.
Efstratios Tsakalidis, Mariangela Giannouli, Ifigeneia Akrani, Anthi Panara, Eleni Katalagarianou, Kyriaki Degaita, Maria Giahou, Konstantina Kyriakou, Maria Routsi, Panagiota Efstathia Nikolaou, Evangelia Tsitsou, Aggeliki Tsoka, Constantinos C. Vorgias, Emmanuel Mikros, Evangelos Gikas, Eleni K. Efthimiadou, Vassilios Myrianthopoulos   +16 more
wiley   +1 more source

RNU4ATAC-opathy: Clinical, molecular, and transcriptomic insights from a large cohort. [PDF]

Genet Med
Matalon DR, Duker AL, Arriaga TM, Russell K, Mendez HR, Bonner DE, Harley ME, Singer-Berk M, Wojcik MH, Pais L, DiTroia S, O'Leary M, Cassini T, Ezell K, Niehaus AD, Kaplan J, Wargowski DS, Smid CJ, Longenecker ED, Rodriguez Barreto AM, Miller DE, Keefe AC, Calderwood L, Enns GM, Tekin M, Bivona SA, Vora NL, Gilmore KL, Khan TN, Davis EE, Wang AW, Khan S, Maddirevula S, Al Abdi L, Abuyousef O, Shamseldin HE, Alkhalifi S, Abdulwahab F, Alqahtani M, Alhumaidi ZA, Nadeef S, Al Hashem AM, Bakur K, Faqeih EA, Abdalla E, Clarke A, Fletcher E, Keng WT, Ousager LB, de Silva DC, Haniffa M, Mari F, Lam W, Campbell J, Homfray T, Nampoothiri S, Li C, Chaudhari BP, Truxal K, Genomics Research to Elucidate the Genetics of Rare Diseases consortium, Undiagnosed Diseases Network, Bernstein JA, Montgomery SB, Wheeler MT, Alkuraya FS, O'Donnell-Luria A, Jackson AP, Campbell IM, Ganesh VS, Robertson N, Lemire G.   +70 more
europepmc   +1 more source

Lacticaseibacillus rhamnosus LRPerfectus158 Alleviates Postinfectious Irritable Bowel Syndrome in Mice and Is Associated With Modulation of Hypothalamic–Pituitary–Adrenal Axis Activity

Food Frontiers, Volume 7, Issue 5, September 2026.
This study demonstrated that administration of Lacticaseibacillus rhamnosus LRPerfectus158 significantly alleviated IBS‐like symptoms in a mouse model by attenuating visceral hypersensitivity, reducing intestinal inflammation, improving epithelial barrier function, and relieving anxiety‐like behaviors.
Dun Su, Yajuan Guo, Yue Wang, Xiaoyue Bai, Guiyuan Yu, Huixian Han, Yizhi Jing, Yuanzhi Yin, Wenjie Chen, Jing Li, Zhengyuan Zhai, Yanling Hao   +11 more
wiley   +1 more source

Draft genome sequence of a resistant diesel fuel degrader <i>Rhodococcus ruber</i> IEGM 442. [PDF]

Microbiol Resour Announc
Komarova L, Krivoruchko A, Kuyukina M, Ivshina I.   +3 more
europepmc   +1 more source

ACE‐inhibitory peptide Leu‐Tyr‐Ala in skeletal muscle actin exhibits anti‐aging effects through the inhibition of acn‐1 in Caenorhabditis elegans

Journal of the Science of Food and Agriculture, Volume 106, Issue 12, Page 7002-7014, September 2026.
Abstract BACKGROUND Inhibitors of angiotensin‐converting enzyme (ACE) are used in pharmaceuticals and functional foods. Captopril, a well‐known ACE inhibitor, extends the lifespan of the nematode Caenorhabditis elegans. Bioactive peptides derived from food sources are considered safe ACE inhibitors.
Issei Yokoyama, Minori Yamane, Kanaho Watanabe, Abdul Fatah, Yusuke Komiya, Jun Nagasao, Keizo Arihara   +6 more
wiley   +1 more source

Complete genome sequence of <i>Bacillus velezensis</i> DDW3, an endophyte isolated from the leaves of <i>Matricaria chamomilla</i>. [PDF]

Microbiol Resour Announc
Du Y, Duan J, Xu Y, Zhang J, Gan X, Xie K, Yang X.   +6 more
europepmc   +1 more source

Disulfide engineering of the FANCM–MHF complex reveals constraints on crosslink design in symmetric oligomers

Protein Science, Volume 35, Issue 9, September 2026.
Abstract The Fanconi anemia complementation group M protein (FANCM)–MHF complex is required for branched DNA recognition in the Fanconi anemia pathway, but structural analysis of the intact complex has been hindered by dissociation of FANCM from the FANCM‐associated histone fold (MHF) heterotetramer under crystallization conditions.
Sho Ito, Tatsuya Nishino
wiley   +1 more source

Staphylococcus aureus Extracellular Vesicles Enhance PslE-Mediated Pathogenesis in Pseudomonas aeruginosa. [PDF]

Microbiologyopen
Subsomwong P, Sukchawalit R, Watabe N, Nakane A, Asano K.   +4 more
europepmc   +1 more source

Molecular logics in dual sensor regulation of diguanylate cyclase activity—Phosphorylation OR blue‐light activation

Protein Science, Volume 35, Issue 9, September 2026.
Abstract Bacterial cells use multiple environmental cues to regulate levels of the second messenger cyclic dimeric GMP. This compound influences key lifestyle decisions such as motility, biofilm formation, or virulence. Although many diguanylate cyclases (DGCs) combined with various sensory domains have been studied previously, how distinct inputs are ...
Maximilian Fuchs, Andreas Winkler
wiley   +1 more source

Draft genome sequence of <i>Salibacterium</i> sp. K-3, a halophilic Mn(II)-oxidizing bacterium. [PDF]

Microbiol Resour Announc
Abdulwahed LA, Greene AC.
europepmc   +1 more source