Results 161 to 170 of about 106,151 (254)

Unifying the Communities of Early‐Onset Glycogen Storage Disease Type IV and Adult Polyglucosan Body Disease Through a Genetic Prevalence Study of GBE1‐Related Disease

JIMD Reports, Volume 67, Issue 3, May 2026.
Genetic prevalence study of glycogen storage disease type IV. In collaboration with the Rare Genomes Project at the Broad Institute of MIT and Harvard and the APBD Research Foundation, this study queried and curated variants in GBE1 from ClinVar, HGMD, and gnomAD to calculate the genetic prevalence of glycogen storage disease type IV (GSD IV).
Rebecca L. Koch, H. Orhan Akman, Erin Chown, Deberah Goldman, Jeff Levenson, Qing Lu, Lindsay T. Michalovicz Gill, Matthew Morgan, Jennifer L. Orthmann‐Murphy, Natacha T. Pires, Rebecca Reef, Harriet Saxe, Moriel Singer‐Berk, Samantha Baxter   +13 more
wiley   +1 more source

Expectations for papers performing Mendelian randomization analyses. [PDF]

PLoS Genet
Williams SM, Tang H, Cooper GM, O'Donnell-Luria A, Girirajan S, Dudley AM, Goriely A, Kutalik Z, Zhu X, Sirugo G, Epstein MP.   +10 more
europepmc   +1 more source

Hydrophobic interactions of a substrate with L193 on the flexible substrate‐binding loop contribute to 3α‐hydroxysteroid dehydrogenase/carbonyl reductase catalytic efficiency

Protein Science, Volume 35, Issue 5, May 2026.
Abstract Flexible loops within enzyme active sites are central to substrate binding, transition‐state stabilization, and catalytic turnover. Hydrophobic interactions modulate ligand recognition and influence protein function. Here, we interrogated loop‐mediated hydrophobic contributions to catalysis in 3α‐hydroxysteroid dehydrogenase/carbonyl reductase
Yan‐Liang Chen, Yun‐Hao Chou, Hwei‐Jen Lee, Tzu‐Pin Wang, Chi‐Ching Hwang   +4 more
wiley   +1 more source

An ALS‐associated mutation in the C‐terminal α‐helix of TDP‐43 uncouples condensate formation and amyloid assembly

Protein Science, Volume 35, Issue 5, May 2026.
Abstract TAR DNA‐binding protein 43 (TDP‐43) plays a critical role in RNA metabolism and is incorporated into biomolecular condensates called stress granules. In amyotrophic lateral sclerosis (ALS) and several other neurodegenerative disorders, TDP‐43 undergoes aberrant phase transitions, forming insoluble amyloid aggregates, including fibrils composed
Emily J. Byrd, Joel A. Crossley, Chalmers C. C. Chau, Paolo Actis, Antonio N. Calabrese   +4 more
wiley   +1 more source

Investigation of antibiofilm activity of bacteriophage ETEC-phage-TG and BC-VP against pathogenic Escherichia coli biofilms. [PDF]

BMC Res Notes
Archell K, Stuart J, Waturangi DE.
europepmc   +1 more source

Structure and Mechanism of PhdC, a Prenylated‐Flavin Maturase

Proteins: Structure, Function, and Bioinformatics, Volume 94, Issue 5, Page 1019-1029, May 2026.
ABSTRACT Prenylated flavin mononucleotide (prFMN) is a modified flavin cofactor required by the UbiD family of (de)carboxylase enzymes. While the reduced prFMNH2 form is produced by the flavin prenyltransferase UbiX, the corresponding two‐electron oxidized prFMNiminium form is required to support UbiD catalysis. Thus, oxidative maturation of prFMNH2 is
Dominic R. Whittall, Henry G. Box, Karl A. P. Payne, Stephen A. Marshall, David Leys   +4 more
wiley   +1 more source

Item-based Parsing of Dynamic Scenes in a Combined Attentional Tracking and Working Memory Task. [PDF]

J Cogn Neurosci
Styrkowiec PP, Ngiam WXQ, Epstein W, Gneezy R, Jones HM, Awh E, Vogel EK.   +6 more
europepmc   +1 more source

Nanovesicle‐Based Delivery of Magnesium Chlorophyllin for Photodynamic Inactivation in Agriculture

Small Science, Volume 6, Issue 5, May 2026.
Nanovesicles based on sodium dodecylbenzenesulfonate (SDBS) and cetyltrimethylammonium bromide (CTAB), prepared with modifiers to either enhance or reduce the stability of the bilayer membrane, can effectively encapsulate the photodynamic agent magnesium chlorophyllin (Mg‐chl) and enable both improved light‐activated bacterial eradication and enhanced ...
Lisha Zhao, Wenzi Ckurshumova, Ava Ettehadolhagh, Jun Liu, Michael Fefer, Todd Hoare   +5 more
wiley   +1 more source

DeNoFo: a file format and toolkit for standardized, comparable de novo gene annotation. [PDF]

Bioinformatics
Dohmen E, Aubel M, Eicholt LA, Roginski P, Luria V, Karger A, Grandchamp A.   +6 more
europepmc   +1 more source

Transmembrane Condensation in Albumin‐Loaded Giant Vesicles Induced by an Intrinsically Disordered Protein

ChemSystemsChem, Volume 8, Issue 3, May 2026.
An intrinsically disordered protein, Q20, forms transmembrane condensates with albumin‐loaded lipid and hybrid giant vesicles. Condensate insertion and membrane remodeling depend on giant vesicle size and membrane properties, inducing local lipid coupling without leakage and revealing a robust membrane‐condensate interplay.
Paula De Dios Andres, Ankush Garg, Ramy Alam, Isabella N. Westensee, Magnus Kjaergaard, Brigitte Städler   +5 more
wiley   +1 more source