Results 191 to 200 of about 73,762 (293)

Kinsenoside Targets IDH1 to Restore Microglial Immune‐Metabolic Homeostasis for Alzheimer's Disease Therapy

Advanced Science, EarlyView.
Dysregulated TCA cycle contributes to Alzheimer's disease (AD) pathogenesis. Here, we show that microglial isocitrate dehydrogenase 1 (IDH1) is a critical driver. Elevated IDH1 disrupts citrate metabolism and mitochondrial function, exacerbating AD pathology.
Qianqian Li, Yajin Liao, Yan‐bo Zhao, Hongxing Wu, Tong Jin, Shuoshuo Li, Yuhan Liu, Peng Li, Songying Ouyang, Zekai Li, YuTing Xia, Qian Hua, Rui‐Yuan Pan, Zengqiang Yuan   +13 more
wiley   +1 more source

Comparison of clinical performance of glass ionomer cement vs. composite resin in restorations of non-carious cervical lesions: A systematic review and meta-analysis. [PDF]

J Clin Exp Dent
Arbildo-Vega HI, Cruzado-Oliva FH, Coronel-Zubiate FT, Luján-Valencia SA, Meza-Málaga JM, Aguirre-Ipenza R, Echevarria-Goche A, Luján-Urviola E, Castillo-Cornock TB, Serquen-Olano K.   +9 more
europepmc   +1 more source

Photodynamic Priming and Minocycline Overcome Chemoresistance by Reprogramming the Pancreatic Tumor Immune Microenvironment In Vivo

Advanced Science, EarlyView.
Dual priming with minocycline and photodynamic priming reprograms the pancreatic tumor microenvironment to overcome chemoresistance. By suppressing DNA repair enzyme Tdp1, inducing photooxidative damage, and enhancing irinotecan delivery via light‐activated nanoencapsulation, this strategy remodels the tumor microenvironment and drives immune ...
Fernanda V. Cabral, Jose Quilez‐Alburquerque, Olivia Mooradian, Shivendran Vytheswarran, Badri Parshad, Girgis Obaid, Huang‐Chiao Huang, Tayyaba Hasan   +7 more
wiley   +1 more source

Glass Formation in the GeSe₂-As₂Se₃-MeCh Systems (Me = Cu, Ag, Zn, Cd, Sn, Pb; Ch = S, Se, Te). [PDF]

Materials (Basel)
Aljihmani L.
europepmc   +1 more source

Microstructure Optimization of Na3SbS4/Na3Zr2Si2PO12 Composite Solid Electrolytes for Improving Cycling Stability in All‐Solid‐State Sodium Batteries

Advanced Science, EarlyView.
This research demonstrates that incorporating 10 wt.% NASICON‐type Na3Zr2Si2PO12 into Na3SbS4 sulfide electrolytes mitigates interfacial instability and structural defects. The resulting composite enhances ionic conductivity to 3.97 * 10−4 S cm−1 and reduces activation energy.
Celastin Bebina Thairiyarayar, Zhenghui Pan, Soorathep Kheawhom, Jeng‐Kuei Chang, Wei‐Ren Liu   +4 more
wiley   +1 more source

Seven New Species of Anastatus Motschulsky (Hymenoptera: Chalcidoidea: Eupelmidae) from China Identified Based on Morphological and Molecular Data. [PDF]

Insects
Wang Z, Zhou Y, Zou Y, Liu Q, Peng L.
europepmc   +1 more source

A High‐Throughput Live Imaging Platform to Investigate Circuit‐Dependent Regulation of Circadian Rhythms in Brain Tissue

Advanced Science, EarlyView.
Biological rhythms coordinate physiology, from genes to behavior. Study of circadian rhythms in brain tissue is constrained by limited throughput and spatial and temporal information quality. A new platform for high‐throughput, long‐term multiplexed fluorescent live imaging of circadian rhythms in brain slices is introduced.
Marco Ferrari, Natalie Ness, Julieta Acosta, Marco Brancaccio   +3 more
wiley   +1 more source

Validation of longitudinal biomarker screening algorithms for HCC detection in patients with cirrhosis. [PDF]

Hepatol Commun
Singal AG, Jin Q, Marrero J, Parikh ND, Lok AS, Lopez C, Page-Lester S, Roberts LR, Reddy R, Luster M, Khaderi S, Asrani SK, El-Serag HB, Kanwal F, Feng Z, Tayob N.   +15 more
europepmc   +1 more source

Biomimetic Bone Marrow Monocyte Membrane‐Fused Extracellular Vesicles for Targeted Therapy of Myocardial Infarction

Advanced Science, EarlyView.
This study develops a biomimetic delivery system (M‐hEV) by fusing monocyte membranes with extracellular vesicles for targeted therapy of damaged cardiac tissue. The system homes to injured myocardium through specific molecular pathways. In a myocardial infarction model, M‐hEV effectively accumulates in the heart, reduces infarct size, alleviates ...
Jiaxin Song, Hao Yang, Qiqi Zhang, Wenqin Zhou, Rui Wang, Yuxing Xie, Emeli Chatterjee, Guoping Li, Jizong Jiang, Qiulian Zhou, Cuimei Zhao   +10 more
wiley   +1 more source