Results 181 to 190 of about 73,762 (293)

Microglia‐Targeted Biomimetic Tetrahedral Framework Nucleic Acid Nanovesicles for Synergistic Treatment of Sepsis‐Associated Encephalopathy

open access: yesAdvanced Science, EarlyView.
Sepsis‐associated encephalopathy (SAE) lacks effective therapies. We developed ME@FDsi, a biomimetic nanodrug using a tetrahedral framework nucleic acid to deliver disulfiram and siTNFα. It crosses the blood‐brain barrier, targets M1 microglia, inhibits pyroptosis and inflammation, and scavenges ROS.
Huimin Shi   +15 more
wiley   +1 more source

Reinforcement of Cathode Interface Using a Dipolar Small Molecule for Enhancing Operational Stability of Perovskite Solar Cells

open access: yesAdvanced Science, EarlyView.
We report a high‐dipole interlayer, MQPPO, that simultaneously improves efficiency and stability in perovskite solar cells. Its strong interfacial dipole enhances photovoltaic performance, while its uniform coverage and strong interaction with Ag effectively suppress AgI formation, ensuring long‐term stability under moisture and thermal stress.
Dong Hyun Lee   +11 more
wiley   +1 more source

Plant‐Derived Melatonin Inhibits Bacterial Virulence via CpxA/R Two‐Component System

open access: yesAdvanced Science, EarlyView.
Plant‐derived melatonin is sensed by CpxAE48/T51, which inhibits the phosphorylation cascade transmission from CpxAH240 to CpxRD52, resulting in the inhibition of DNA‐binding capacity of CpxR and subsequent T3SS genes expression in Pst DC3000. ABSTRACT In defending against pathogens, plants deploy diverse secondary metabolites and signaling molecules ...
Jin‐Wei Wei   +7 more
wiley   +1 more source

Enzymatic Basis for the Oxidative Branch of Aromatic Amino Acid Fermentation Leading to p‐cresol Formation

open access: yesAdvanced Science, EarlyView.
In anaerobic bacteria, tyrosine serves as an electron donor in the oxidative Stickland fermentation branch, generating p‐hydroxyphenylacetate, ATP and reduced ferredoxin for decarboxylation into p‐cresol. ABSTRACT The phenolic metabolite p‐cresol is a byproduct of tyrosine fermentation by certain strictly anaerobic bacteria, including the human gut ...
Li Jiang   +15 more
wiley   +1 more source

A Cross-Sectional Study of Acceptability and Influence of HEALing Communities Study Communications Campaign Messaging Among Community Members in Four U.S. States. [PDF]

open access: yesAm J Health Promot
Luster J   +10 more
europepmc   +1 more source

Non‐Invasively Tracking an Arbitrary Deformable Object Through Scattering Media and Around Corners via Speckle Correlations

open access: yesAdvanced Science, EarlyView.
A speckle correlation centroid localization method (SCCLM) is proposed for non‐invasive tracking of an arbitrary deformable object through scattering media and around corners, requiring no prior information. Its effectiveness is demonstrated not only in tracking hidden objects beyond the memory effect region but also in following objects undergoing ...
Aiping Zhai   +6 more
wiley   +1 more source

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