Results 101 to 110 of about 127,194 (360)

Investigating the KNDy hypothesis in humans by co-administration of kisspeptin, neurokinin B and naltrexone in men [PDF]

, 2016
Context: A subpopulation of hypothalamic neurons co-localise three neuropeptides namely kisspeptin, neurokinin B (NKB) and dynorphin collectively termed KNDy neurons. Animal studies suggest they interact to affect pulsatile GnRH release (KNDy hypothesis);
Abbara, A, Bassett, P, Bloom, S, COMNINOS, A, Dhillo, WS, Jayasena, C, Mizamtsidi, M, Narayanaswamy, S, Papadopoulou, D, Prague, J, Shah, A, Veldhuis, J   +11 more
core   +1 more source

Considerations of Fertility in Elite Sportswomen: A Narrative Review

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Background Increasingly more women are participating in professional and recreational sports. Whilst vigorous intensity physical activity is considered beneficial, evidence demonstrates higher rates of menstrual disturbance in elite athletes. There is less clear evidence on the impact of elite‐level exercise on fertility outcomes.
Ariadne L'Heveder, Rachel E. Roberts, Amal Hassan, Lorraine Kasaven, Srdjan Saso, Timothy Bracewell‐Milnes, James Nicopoullos, Meen‐Yau Thum, Helen C. O'Neill, Noel Pollock, James Brown, Benjamin P. Jones   +11 more
wiley   +1 more source

Advent of NK3R Antagonists for the Treatment of Menopausal Hot Flushes: A Narrative Review

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT The menopause transition is marked by symptoms predominantly attributed to declining oestrogen levels. Approximately 80% of women experience associated symptoms, and 25% experience severe symptoms. The commonest are vasomotor symptoms (VMS), collectively referring to hot flushes and/or night sweats.
Aaran H. Patel, Aureliane Pierret, Edouard G. Mills, Alexander N. Comninos, Waljit S. Dhillo, Ali Abbara   +5 more
wiley   +1 more source

Genetic and sex hormone analysis of infertile men

Journal of International Medical Research, 2020
Objective Genetic defects and endocrine-related factors are the leading causes of male infertility. This study was performed to analyze the genetic characteristics and sex hormone levels in different types of male infertility.
Xiaolei Xie, Xiaoyan Guo, Fuguang Li, Weihe Tan, Weiguo Yin, Runqinag Chen   +5 more
doaj   +1 more source

The Effect of Assisted Reproductive Technologies on Human Sex Ratios

Australian and New Zealand Journal of Obstetrics and Gynaecology, EarlyView.
ABSTRACT Background Modern assisted reproductive technology (ART), including pre‐implantation genetic testing for aneuploidy (PGT‐A), has opened new avenues in understanding early embryonic events and has simultaneously raised questions about the impact of ART itself on sex ratios.
Ektoras X. Georgiou, Yossi Mizrachi, Rebecca Kelley, Sharyn Stock‐Myer, John Stevens, David K. Gardner, Alex Polyakov   +6 more
wiley   +1 more source

Effect of Ghrelin Antagonist on Serum Testosterone and Luteinizing Hormone in Obese Type 2 Diabetic Mice

Journal of Rawalpindi Medical College, 2014
Background: To determine the effect of ghrelin antagonist (D-Lys3) on plasma glucose, insulin resistance, serum testosterone and luteinizing hormone levels, on obese and type 2 diabetic mice.
Lubna Siddique
doaj   +2 more sources

The Pathogenic TSH β-Subunit Variant C105Vfs114X Causes a Modified Signaling Profile at TSHR [PDF]

, 2019
1) Background: Central congenital hypothyroidism (CCH) is a rare endocrine disorder that can be caused by mutations in the β-subunit of thyrotropin (TSHB).
Biebermann, Heike, Grüters-Kieslich, Annette, Kalveram, Laura, Kleinau, Gunnar, Rivero-Müller, Adolfo, Scheerer, Patrick, Szymańska, Kamila   +6 more
core   +1 more source

ACCEPT Group Condensed Position Paper on the Management of Recurrent Pregnancy Loss

Australian and New Zealand Journal of Obstetrics and Gynaecology, EarlyView.
ABSTRACT The Australasian CREI (Certificate of Reproductive Endocrinology and Infertility) Consensus Expert Panel on Trial Evidence (ACCEPT) group recently published an evidence‐based guideline on the investigation and management of recurrent pregnancy loss (RPL).
Adriana Suker, Ying Li, Anthony Marren, Danielle Robson, the Australasian CREI (Certificate of Reproductive Endocrinology and Infertility) Consensus Expert Panel on Trial evidence (ACCEPT) Group   +4 more
wiley   +1 more source

Quality of life effects of androgen deprivation therapy in a prostate cancer cohort in New Zealand: Can we minimize effects using a stratification based on the aldo-keto reductase family 1, member C3 rs12529 gene polymorphism? [PDF]

, 2016
Background: Androgen deprivation therapy (ADT) is an effective palliation treatment in men with advanced prostate cancer (PC). However, ADT has well documented side effects that could alter the patient's health-related quality of life (HRQoL).
Benjamin, Benji, Ellett, Stephanie, Ferguson, Lynnette R., Goudie, Megan, Han, Dug Yeo, Holmes, Michael, Karunasinghe, Nishi, Keogh, Justin, Lange, Katja, Masters, Jonathan, Wang, Alice, Zhu, Shuotun, Zhu, Yifei   +12 more
core   +2 more sources

Testicular histopathology and its association with germ cell numbers, serum concentrations of reproductive hormones, and semen quality

Andrology, EarlyView.
Abstract Background It is well‐established that spermatogenesis, semen quality, and reproductive hormones are interlinked. It is, however, less well‐described how various specific testicular histopathologies are linked to reproductive hormones and semen quality.
Gülizar Saritas, Nina Mørup, Trine H. Johannsen, Anders Juul, Lise Aksglaede, Sofia B. Winge, Kristian Almstrup   +6 more
wiley   +1 more source