Results 111 to 120 of about 149 (149)

Opioid Therapy in Chronic Pain: Assessment of Clinical Outcomes and Relationships With Endocrine Biomarkers

European Journal of Pain, Volume 29, Issue 6, July 2025.
ABSTRACT Background Long‐term opioid treatment (L‐TOT) may have consequences that are mediated by factors affecting functionality and health‐related quality of life. This study aimed at investigating associations between L‐TOT and clinical outcomes including sustained attention, short‐term and working memory, worst pain intensity, sleep quality, mood ...
Dalia Abou‐Kassem, Pernille Døssing Kwateng Diasso, Per Sjøgren, Katharina Maria Main, Susanne Dam Nielsen, Geana Paula Kurita   +5 more
wiley   +1 more source

Recommendations for the management of GnRH‐ant for ovarian stimulation in the assistant reproductive process: Benefits and harms for different ovarian response population

Clinical and Public Health Guidelines, Volume 2, Issue 3, July 2025.
Abstract Introduction: Gonadotropin‐releasing hormone antagonists (GnRH‐ant) are commonly used during controlled ovarian stimulation (COS) in the in vitro fertilization (IVF) process to prevent premature luteinization and to ensure follicles mature synchronously.
Rong Li, Rui Yang, Junhao Yan, Yang Song, Yunxia Cao, Zijiang Chen, Chenchen Xu, Zhan Zhao, Yichun Guan, Fei Gong, Guimin Hao, Hefeng Huang, Li Jin, Fenghua Liu, Jiayin Liu, Xiaoyan Liang, Xiaolin La, Yun Sun, Xiaohong Wang, Yanwen Xu, Cuilian Zhang, Jie Qiao   +21 more
wiley   +1 more source

Primary Analysis of (NCT03380806) a Phase II Randomized Trial of Stereotactic Body Radiotherapy Boost Versus Conventional Fractionation External Beam Radiotherapy Boost in Unfavorable‐Intermediate and High‐Risk Prostate Cancer

The Prostate, Volume 85, Issue 10, Page 977-985, July 2025.
ABSTRACT Background Standard treatment for unfavorable‐intermediate and high‐risk prostate cancer involves androgen deprivation therapy (ADT) in combination with pelvic conventional fractionation (CF) external beam radiotherapy (EBRT) and a CF‐EBRT or brachytherapy boost to the prostate.
Andre Gouveia, Aruz Mesci, Naghmeh Isfahanian, Ian Dayes, Kimmen Quan, Mira Goldberg, Kara Lynne Schnarr, Himu Lukka, David Cuthbert, Abhiram Hallock, Georgia Douvi, Jim Wright, Anand Swaminath, Tom Chow, Kevin Diamond, George Hajdok, Lindsay Maharaj, Joycelyne Ewusie, Theodoros Tsakiridis   +18 more
wiley   +1 more source

Long Noncoding RNA NONHSAT233728.1 Promotes ROS Accumulation and Granulosa Cell Apoptosis by Regulating the MAPK/ERK1/2 Signaling Pathway

The FASEB Journal, Volume 39, Issue 11, 15 June 2025.
Through isolation and transcriptomic profiling of granulosa cells, we identified the functional significance of lncRNA NONHSAT233728.1 in polycystic ovary syndrome (PCOS) pathogenesis. Knockdown of lncRNA NONHSAT233728.1 in granulosa cells elevated ROS levels, reduced the Bcl2/Bax ratio, downregulated phospho‐ERK1/2, and increased IL‐8 secretion. These
Yao Chen, Heqi Dai, Fei Mao, Yangbai Li, Ruizhi Feng, Yun Qian   +5 more
wiley   +1 more source

Hydrogen sulfide repairs testicular damage induced by heat stress in rats

FEBS Open Bio, Volume 15, Issue 6, Page 963-971, June 2025.
Heat stress can cause testicular damage and affect fertility. We investigated the potential protective role of hydrogen sulfide (H2S) against heat stress‐induced testicular injury and observed that H2S donor NaHS can effectively restore testicular damage in rats by inhibiting inflammation and oxidative stress. Our results suggest that H2S might be used
Xinyu Guo, Yupeng Yin, Susu Guo, Xiaoyan Chen, Suyan Xie, Shiqin Chen, Yan Huang   +6 more
wiley   +1 more source

Exploring of Antidepressant Components and Mechanisms of Zhizichi Decoction: Integration of Serum Pharmacochemistry, Network Pharmacology and Anti‐inflammatory Analysis Verification

Analytical Science Advances, Volume 6, Issue 1, June 2025.
ABSTRACT Using LC–MS to screen and analyse the characteristics of components and biological systems is a new approach to study the pharmacological substance basis of traditional Chinese medicine, which has strong novelty in analytical science. This study analyses the antidepressant material basis of Zhizichi decoction through the integration strategy ...
Chuan Chai, Bo Jin, Jinghan Bi, Yuhan Cui, Xiaobing Cui, Chenxiao Shan, Sheng Yu, Hongmei Wen   +7 more
wiley   +1 more source

Bilateral Ovarian Hemangiomas Presenting With Abnormal Uterine Bleeding: A Rare Case Report

Clinical Case Reports, Volume 13, Issue 6, June 2025.
ABSTRACT Ovarian hemangiomas are rare benign vascular tumors that can present with abnormal uterine bleeding and mimic malignant ovarian lesions. Imaging may be inconclusive, and histopathology remains essential for diagnosis. This case highlights the importance of considering ovarian hemangiomas in the differential diagnosis of pelvic masses to ensure
Ensiyeh Bahadoran, Fatemeh SamieeRad
wiley   +1 more source

Impact of maintenance treatment on male gonadal function in patients treated for localized rhabdomyosarcoma in RMS2005 trial in France

Cancer, Volume 131, Issue 11, 1 June 2025.
Abstract Background Maintenance treatment with vinorelbine and oral cyclophosphamide (oral‐CPM) improves outcome of nonmetastatic high‐risk (HR) and very‐high risk (VHR) rhabdomyosarcoma (RMS) patients. However, gonadal toxicity of maintenance was not yet investigated. Methods The authors focused their analysis on male gonadal toxicity in HR/VHR groups
Lea Rossillon, Cécile Thomas‐Teinturier, Daniel Orbach, Marie‐Dominique Tabone, Amandine Bertrand, Sophie Ansoborlo, Anne‐Sophie Defachelles, Angelique Rome, Stéphanie Haouy, Dominique Plantaz, Stéphanie Bolle, Valérie Bernier‐Chastagner, Florent Guerin, Sabine Sarnacki, Pascale Philippe‐Chomette, Rodrigue Allodji, Laura Lenez, Lucy Métayer, Virginie Barraud‐Lange, Véronique Minard‐Colin, Brice Fresneau   +20 more
wiley   +1 more source

Clinical evaluation and outcome in heart failure patients receiving chemotherapy with different anti‐cancer agents

ESC Heart Failure, Volume 12, Issue 3, Page 1965-1976, June 2025.
Abstract Background The optimal strategy for modern chemotherapy should be based on a comprehensive approach for cancer patients with cardiovascular diseases. Therefore, cardio‐oncology has received increasing attention owing to the cardiotoxic effects of anti‐cancer therapies.
Tomiko Sunaga, Takahiro Okada, Yoshitaka Iso, Mio Ebato, Tsutomu Toshida, Shuichi Nawata, Hiroshi Suzuki, Mari Kogo   +7 more
wiley   +1 more source

Cisplatin‐Induced Muscle Wasting and Atrophy: Molecular Mechanism and Potential Therapeutic Interventions

Journal of Cachexia, Sarcopenia and Muscle, Volume 16, Issue 3, June 2025.
ABSTRACT Platinum‐based chemotherapeutics, particularly cisplatin, are crucial in the treatment of various malignancies due to their strong antitumor effects. However, a significant side effect of cisplatin is muscle atrophy, which severely impairs physical strength, diminishes quality of life and complicates cancer therapy.
Ko‐Chieh Huang, Yi‐Fen Chiang, Mohamed Ali, Shih‐Min Hsia   +3 more
wiley   +1 more source