Results 41 to 50 of about 71,128 (264)

Pharmacokinetics, pharmacodynamics and safety of vutiglabridin after multiple oral administrations in healthy female and obese subjects

British Journal of Clinical Pharmacology, EarlyView.
Aims Vutiglabridin (HSG4112) is a novel drug under clinical development for antiobesity treatment. This study aimed to evaluate the pharmacokinetics (PKs) and safety of vutiglabridin after multiple oral administrations in healthy Korean female and obese subjects and explore short‐term pharmacodynamic (PD) responses.
Sooyoun Lee, Hyun Chul Kim, Young Ran Yoon, In‐Jin Jang, Sang‐Ku Yoo, Kyung‐Sang Yu   +5 more
wiley   +1 more source

Assessment of hormonal activity in patients with premature ejaculation

International Brazilian Journal of Urology
Purpose Premature ejaculation is considered the most common type of male sexual dysfunction. Hormonal controls of ejaculation have not been exactly elucidated. The aim of our study is to investigate the role of hormonal factors in patients with premature
Lütfi Canat, Akif Erbin, Masum Canat, Mehmet Dinek, Turhan Çaşkurlu   +4 more
doaj   +1 more source

Success Rates of Clomiphene Citrate and Recombinant Gonadotropin Cycles: A Single-Center Experience

Gynecology Obstetrics & Reproductive Medicine, 2020
Objective: This aim of this study is to assess the ovulation induction cycles based on clomiphene citrate and gonadotropin administration and specify the factors associated with successful outcomes.
Beril Gurlek, Ali Sertac Batioglu, Mine Kanat-Pektas, Ibrahim Kale, Ozgur Onal, Nafiye Yilmaz-Karakas   +5 more
doaj   +1 more source

Pharmacokinetics, Tolerability, and Biomarker Profile of the Neurokinin 3 Receptor Antagonist Fezolinetant in Healthy Japanese Individuals: A 2‐Part, Randomized, Phase 1 Study

Clinical Pharmacology in Drug Development, EarlyView.
Abstract This 2‐part, randomized, placebo‐controlled, double‐blind, Phase 1 study analyzed the pharmacokinetics, safety, and biomarker profile of fezolinetant in healthy Japanese individuals. Part 1: male participants received single doses of placebo or fezolinetant 15 or 60 mg.
Akira Koibuchi, Megumi Iwai, Kanji Komatsu, Kentaro Kuroishi, Mai Shibata, Masako Saito, Jace Nielsen, Jiayin Huang, Shunji Matsuki   +8 more
wiley   +1 more source

Decreased Ovarian Reserve Predicts Inexplicability of Recurrent Miscarriage? A Retrospective Analysis. [PDF]

PLoS ONE, 2016
OBJECTIVE:To evaluate anti-Mullerian hormone, basal follicle stimulating hormone, luteinizing hormone, estradiol, and female age in women with recurrent miscarriage and to compare women with explained and idiopathic recurrent miscarriage.
Sophie Pils, Regina Promberger, Stephanie Springer, Elmar Joura, Johannes Ott   +4 more
doaj   +1 more source

Prevalence of AAS‐Positive Samples at Drug Abuse Laboratory Sweden Between 2014 and 2023 and Sub‐Study of Dual Use of AAS and Narcotics

Drug Testing and Analysis, EarlyView.
Throughout 2014–2023, over 20,000 AAS analyses have been conducted at the drug of abuse laboratory, Karolinska University Hospital. Approximately 20% and 2% of the samples have been positive for AAS, with no trends of increase or decrease. Around 50% of the AAS‐positive samples were also positive for narcotics (year 2022–2023), with gender differences;
Kim Petterson Bohlin, Tomas Villén, Oscar Hopcraft, Anton Pohanka, Lena Ekström   +4 more
wiley   +1 more source

Luteinizing hormone beta gene polymorphism and its effect on semen quality traits and luteinizing hormone concentrations in Murrah buffalo bulls [PDF]

Asian-Australasian Journal of Animal Sciences, 2018
Objective Present investigation was aimed to study the Single Nucleotide Variants of the luteinizing hormone beta (LHβ) gene and to analyze their association with the semen quality (fresh and post-thawed frozen semen) and luteinizing hormone (LH ...
Jagish Kour Reen, Ramesha Kerekoppa, Revanasiddu Deginal, Maneesh Kumar Ahirwar, Uday Kannegundla, Satish Chandra, Divya Palat, Dayal Nitai Das, Mukund Amritrao Kataktalware, Sakthivel Jeyakumar, Shri krishna Isloor   +10 more
doaj   +1 more source

A review of the impact of micro‐ and nanoplastics on female reproduction: What we know and gaps in knowledge

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Micro‐and nanoplastics (MNPs) are breakdown products of plastics, and humans are exposed to these particles through air, water, food, and soil. There is a growing concern that human exposure to MNPs negatively impacts health. In this review we will discuss the potential health impact of MNPs on ovarian function and the hypothalamic–pituitary ...
Sanchayana Raghuvir, Shawn Alex, Deborah Clegg   +2 more
wiley   +1 more source

Evaluation of the diagnostic value of different serum biomarkers in girls with central precocious puberty

Egyptian Pediatric Association Gazette
Background Alarming trends show an increase in referrals of girls with suspected early puberty. However, variations in defining precocious puberty exist.
Yasmine Abdelmeguid, Omneya Abdelkarem, Shaymaa Raafat   +2 more
doaj   +1 more source

Pregnancy via Testicular Sperm Extraction for Anejaculation After Neuroblastoma Surgery

IJU Case Reports, EarlyView.
ABSTRACT Background Surgical treatment of a neuroblastoma, a malignant tumor of the sympathetic nervous system, may result in ejaculatory disorder. There are no reports examining ejaculation disorders after neuroblastoma surgery. Case Presentation The patient was a 31‐year‐old Japanese male who had undergone surgery for neuroblastoma of the abdomen at ...
Jurii Karibe, Teppei Takeshima, Daiji Takamoto, Takashi Kawahara, Kimito Osaka, Jun‐ichi Teranishi, Kazuhide Makiyama, Hiroji Uemura, Yasushi Yumura   +8 more
wiley   +1 more source