Results 41 to 50 of about 130,431 (351)

Pharmacokinetics, pharmacodynamics and safety of vutiglabridin after multiple oral administrations in healthy female and obese subjects

British Journal of Clinical Pharmacology, EarlyView.
Aims Vutiglabridin (HSG4112) is a novel drug under clinical development for antiobesity treatment. This study aimed to evaluate the pharmacokinetics (PKs) and safety of vutiglabridin after multiple oral administrations in healthy Korean female and obese subjects and explore short‐term pharmacodynamic (PD) responses.
Sooyoun Lee, Hyun Chul Kim, Young Ran Yoon, In‐Jin Jang, Sang‐Ku Yoo, Kyung‐Sang Yu   +5 more
wiley   +1 more source

Association of the genetic variants of luteinizing hormone, luteinizing hormone receptor and polycystic ovary syndrome

Reproductive Biology and Endocrinology, 2012
Background High circulating luteinizing hormone (LH) level is a typical biochemical feature of polycystic ovary syndrome (PCOS) whose pathophysiology is still unclear.
Liu Nana, Ma Yanmin, Wang Shuyu, Zhang Xiaowei, Zhang Qiufang, Zhang Xue, Fu Li, Qiao Jie   +7 more
doaj   +1 more source

Low estrogen doses normalize testosterone and estradiol levels to the female range in transgender women

Clinics, 2018
OBJECTIVE: The ideal dosage of cross-sex hormones remains unknown. The aim of this study was to evaluate the luteinizing hormone, follicle-stimulating hormone, testosterone, estradiol and prolactin levels after low-dose estrogen therapy with or without ...
Flávia Siqueira Cunha, Sorahia Domenice, Maria Helena Palma Sircili, Berenice Bilharinho de Mendonca, Elaine Maria Frade Costa   +4 more
doaj   +1 more source

Utility of Ovarian Tumour Marker Cancer Antigen-125 and Endocrine Hormonal Status in Polycystic Ovary Syndrome [PDF]

Journal of Clinical and Diagnostic Research, 2018
Introduction: Polycystic Ovary Syndrome (PCOS) is the most common endocrinopathy in women of reproductive age. Women with PCOS are at increased risk of reproductive abnormalities with a prevalence of up to 10%.
Shahid Akbar Mujawar, Vilas Namdeorao Kurude, Harshada Ashok Gaikwad, Vinayak Wamanrao Patil   +3 more
doaj   +1 more source

Mapping molluscan endocrinology: a systematic and critical appraisal

Biological Reviews, EarlyView.
ABSTRACT Historically, a vertebrate‐centric paradigm has framed our interpretation of molluscan endocrinology, with considerable research focusing on vertebrate‐type steroid hormones (e.g. oestrogens, testosterone). However, contradictory evidence on the occurrence of vertebrate‐type steroid hormones in molluscan tissues, and a lack of the specific ...
Konstantinos Panagiotidis, Thomas H. Miller, Olwenn V. Martin, Alice Baynes   +3 more
wiley   +1 more source

Dose-Response relationship of luteinizing hormone to luteinizing hormone—releasing hormone in man [PDF]

Journal of Clinical Investigation, 1971
In previous clinical studies with highly purified porcine luteinizing hormone-releasing hormone (LH-RH), administration of the somewhat arbitrarily chosen doses of 700-1500 mug resulted in increased serum levels of luteinizing hormone (LH) and follicle-stimulating hormone (FSH).
A J, Kastin, A V, Schally, C, Gual, A R, Midgley, M C, Miller, A, Cabez   +5 more
openaire   +2 more sources

Real‐World Effectiveness and Safety of Recombinant Human Follicle‐Stimulating Hormone (rhFSH) in Infertile Women undergoing Assisted Reproductive Technology (ART): A Korean Nationwide Cohort Study

Clinical Pharmacology &Therapeutics, EarlyView.
Despite widespread rhFSH use in infertile women undergoing ART, real‐world comparative data on its effectiveness and safety across different rhFSH types remain limited. Using the HIRA claims database, we included 10,684 women aged 20–39 with infertility (2016–2021) who used only rhFSH in their first in vitro fertilization–embryo transfer (IVF‐ET ...
Joong Yeup Lee, Eun‐Young Choi, Jung Ryeol Lee, Young Sik Choi, Ji Hyang Kim, Chang‐Woo Choo, Yunju Choe, Hee‐Jin Seo, Hyesung Lee, Yujeong Shin, Yejin Jeon, Ju‐Young Shin, Hoon Kim   +12 more
wiley   +1 more source

Persistent organochlorine pollutants with endocrine activity and blood steroid hormone levels in middle-aged men. [PDF]

PLoS ONE, 2013
BACKGROUND: Studies relating long-term exposure to persistent organochlorine pollutants (POPs) with endocrine activities (endocrine disrupting chemicals) on circulating levels of steroid hormones have been limited to a small number of hormones and ...
Elise Emeville, Frank Giton, Arnaud Giusti, Alejandro Oliva, Jean Fiet, Jean-Pierre Thomé, Pascal Blanchet, Luc Multigner   +7 more
doaj   +1 more source

Role of androgen and gonadotrophins in the development and function of the Sertoli cells and Leydig cells: data from mutant and genetically modified mice [PDF]

, 2009
Development and maintenance of the male phenotype and establishment of fertility are all dependent upon the activity of the Sertoli cells and Leydig cells of the testis.
Abel, M.H., Baker, P.J., Huhtaniemi, I., Morris, I.D., O'Shaughnessy, P.J.   +4 more
core   +1 more source

Pituitary response to luteinizing hormone-releasing hormone in women with variant luteinizing hormone [PDF]

European Journal of Endocrinology, 2000
OBJECTIVE: To assess the LH response of the pituitary gland to GnRH stimulation in healthy women with a mutant beta-subunit (Trp8 to Arg8 and Ile15 to Thr15). DESIGN: Clinical study. PATIENTS: We studied 40 healthy non-pregnant Japanese women of known zygosity for the LH beta-subunit gene (3 homozygotes for the mutant gene, 17 heterozygotes, and 20 ...
K, Takahashi, H, Kurioka, T, Ozaki, H, Kanasaki, K, Miyazaki, K, Karino   +5 more
openaire   +2 more sources