Role of the LuxR solo, SdiA, in eavesdropping on foreign bacteria
Abstract Bacteria can cooperate by coordinating their gene expression through the production, release, and detection of small molecules, a phenomenon known as quorum sensing (QS). One type of QS commonly found in Gram-negative bacteria utilizes a LuxI-type enzyme to produce a signaling molecule of the N-acyl-homoserine lactone (AHL ...
Andrew Schwieters, Brian M M Ahmer
openaire +2 more sources
Structure and schematic behaviour of the LuxR-repressible promoters. [PDF]
A) Schematic representation of the working principle of the repressible promoters. In the blue and red boxes the two synthetic networks representing the constitutive LuxR expression cassette and the LuxR-regulated RFP expression cassette are shown ...
Giuliano Mazzini (122977) +6 more
core +1 more source
We developed a genome‐integrated CRISPR/Cas12a system for Xenorhabdus budapestensis XBD8, which enables precise deletion or replacement of DNA fragments ranging from 379 to 45,168 bp, with a success rate exceeding 90%. Application of this tool for the dynamic regulation of fabclavine‐8 biosynthesis resulted in a 1.90‐fold increase in production ...
Wenfeng Gan +4 more
wiley +1 more source
LuxR Solos in the Plant Endophyte Kosakonia sp. Strain KO348
Cell-cell signaling in bacteria allows a synchronized and coordinated behavior of a microbial community. LuxR solos represent a subfamily of proteins in proteobacteria which most commonly detect and respond to signals produced exogenously by other microbes or eukaryotic hosts.
Mosquito Susan +9 more
openaire +3 more sources
Analysis of LuxR Regulon Gene Expression during Quorum Sensing in Vibrio fischeri [PDF]
The regulation of the lux operon (luxICDABEG) of Vibrio fischeri has been intensively studied as a model for quorum sensing in proteobacteria. Two-dimensional sodium dodecyl sulfate-polyacrylamide gel electrophoresis analysis previously identified ...
Sean M. Callahan +7 more
core +1 more source
A Burkholderia cenocepacia Orphan LuxR Homolog Is Involved in Quorum-Sensing Regulation [PDF]
ABSTRACT Burkholderia cenocepacia utilizes quorum sensing to control gene expression, including the expression of genes involved in virulence. In addition to CepR and CciR, a third LuxR homolog, CepR2, was found to regulate gene expression and virulence factor production. All B.
Malott Rebecca J +5 more
openaire +3 more sources
Halogenated furanones inhibit quorum sensing through accelerated LuxR turnover [PDF]
N-acyl-L-homoserine lactones (AHLs) are co-regulatory ligands required for control of the expression of genes encoding virulence traits in many Gram-negative bacterial species.
Steinberg, Peter +11 more
core
An Evolving Perspective on the Pseudomonas aeruginosa Orphan Quorum Sensing Regulator QscR
Many Proteobacteria govern responses to changes in cell density by using acyl-homoserine lactone (AHL) quorum-sensing (QS) signaling. Similar to the LuxI-LuxR system described in Vibrio fischeri, a minimal AHL QS circuit comprises a pair of genes, a luxI-
Everett Peter Greenberg, Sudha eChugani
doaj +1 more source
LuxR-dependent quorum sensing: Computer aided discovery of new inhibitors structurally unrelated to N-acylhomoserine lactones [PDF]
International audienceA virtual screening, involving flexible docking sequences within the LuxR, TraR and LasR binding sites, was used as a structural binding sites similarity filter to specifically target conserved residues in the proteins of the LuxR ...
Laurent Soulère +9 more
core +1 more source
2-Substituted Aniline as a Simple Scaffold for LuxR-Regulated QS Modulation
The ability of the 2-substituted aniline motif to serve as a scaffold for designing potential LuxR-regulated quorum sensing (QS) modulators has been investigated, using docking experiments and biological evaluation of a series of 15 specially synthesized
Sizhe Li +3 more
doaj +1 more source

