Results 41 to 50 of about 246 (103)

A Nutrient‐Responsive LuxR Regulator Orchestrates Effector Gene Expression Across the Legionella Genus

open access: yesMolecular Microbiology, Volume 126, Issue 3, Page 283-300, September 2026.
LexR1 is a LuxR‐type regulator that links nutrient sensing to effector gene expression in Legionella. Activated by a casamino acid‐derived ligand, LexR1 directly controls multiple effector genes using a conserved regulatory element present in numerous putative effectors across different Legionella species.
Chen Adler, Gil Segal
wiley   +1 more source

Unlocking the Bioactive Potential of Streptomyces: A Multidisciplinary Approach to Strain Improvement

open access: yesMicrobiologyOpen, Volume 15, Issue 4, August 2026.
This paper aims to address critical gaps in the literature by providing a comprehensive, integrative synthesis of recent advances in Streptomyces strain improvement, with a particular focus on optimizing secondary metabolite production through a multidisciplinary approach.
Anum Goraya   +5 more
wiley   +1 more source

LuxR Solos are Becoming Major Players in Cell-Cell Communication in Bacteria

open access: yes, 2016
The most common quorum sensing (QS) system in Gram-negative bacteria occurs via N-acyl homoserine lactone (AHLs) signals. An archetypical system consists of a LuxI-family protein synthesizing the AHL signal which binds at quorum concentrations to the cognate LuxR-family transcription factors which then control gene expression by binding to specific ...
Vittorio Venturi, Brian M.M. Ahmer
openaire   +3 more sources

Living Microbial Drugs

open access: yesChemistry – A European Journal, Volume 32, Issue 26, 11 July 2026.
The introduction outlines the review scope. Microbial cell factories as living drugs cover host–gut microbiota, bacteria, yeast, and other microbial systems, with comparative host advantages. Engineering strategies include synthetic circuits, quorum sensing, and memory.
Cemile Elif Özçelik   +3 more
wiley   +1 more source

A genome‐integrated CRISPR/Cas12a system enables efficient genetic engineering in Xenorhabdus budapestensis XBD8

open access: yesNew Plant Protection, Volume 3, Issue 2, June 2026.
We developed a genome‐integrated CRISPR/Cas12a system for Xenorhabdus budapestensis XBD8, which enables precise deletion or replacement of DNA fragments ranging from 379 to 45,168 bp, with a success rate exceeding 90%. Application of this tool for the dynamic regulation of fabclavine‐8 biosynthesis resulted in a 1.90‐fold increase in production ...
Wenfeng Gan   +4 more
wiley   +1 more source

Functional Characterisation of the Quorum‐Sensing Regulator ExpREcz in Modulation of Dickeya oryzae Motility and Virulence

open access: yesMolecular Plant Pathology, Volume 27, Issue 6, June 2026.
In the absence of OHHL synthase ExpIEcz, ExpREcz represses self‐expression via EDDR region and regulates Dickeya oryzae virulence traits. OHHL synthesised via ExpIEcz abolishes ExpREcz function but promotes OHHL production and D. oryzae virulence.
Zhibin Liang   +8 more
wiley   +1 more source

Attenuated Bacteria‐Based Tumor Therapy: Clinical Application Risks, Marketing Approval Restrictions, and Coping Strategies

open access: yesAdvanced Science, Volume 13, Issue 16, 18 March 2026.
This review comprehensively overviews attenuated bacteria‐based tumor therapy, highlighting key methodologies and recent progress. It examines strategies for enhancing safety, stabilizing efficacy, optimizing manufacturing, and navigating regulatory pathways.
Yucheng Liu   +8 more
wiley   +1 more source

A Comprehensive Review of the Multitarget Effects of Subinhibitory Concentrations of Essential Oils Against Salmonella

open access: yesComprehensive Reviews in Food Science and Food Safety, Volume 25, Issue 2, March 2026.
ABSTRACT Essential oils (EOs) exhibit antimicrobial activity against foodborne pathogens due to their chemical composition. This review investigates the mechanisms of action of EOs at subinhibitory concentrations against Salmonella strains. Even at subinhibitory concentrations, EOs induce cellular stress and modulate bacterial metabolism. EOs interfere
Carolina Ramos   +5 more
wiley   +1 more source

SUPER: Upcycling Genetic Parts for Precise Gene Expression Control, Leakage Minimization, and Genetic Circuit Stability

open access: yesAdvanced Science, Volume 13, Issue 12, 27 February 2026.
To precisely modulate natural and synthetic regulatory parts, SUPER is introduced as a sophisticated and tunable controller of genetic devices without requiring sequence modification on the target. SUPER enhances dynamic range of RNA‐, chemical‐, temperature‐, and protein‐responsive biosensors up to 1011%, and converts biosensors to cover an expanded ...
Taeyang Heo   +3 more
wiley   +1 more source

Pan‐Genomic and Phenotypic Characterisation of Petroleum Hydrocarbon Degradation by Pseudomonas Species

open access: yesEnvironmental Microbiology Reports, Volume 18, Issue 1, February 2026.
Pseudomonas is one of the most significant bacterial genus involved in the petroleum hydrocarbon bioremediation. Innovatively, through pan‐genomic analysis at the genus level, we found that different Pseudomonas strains have excellent complementarity at the nodes of the degradation pathway of petroleum hydrocarbons.
Xiaopeng Guo   +9 more
wiley   +1 more source

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