Results 21 to 30 of about 157 (83)

Chemical inhibition of cPLA₂ affects the A. phagocytophilum-induced NLRC4 inflammasome.

, 2016
Wildtype (WT) BMDMs (1 x106 cells) pre-treated for 30 minutes with pharmacological inhibitors of secreted PLA2 (sPLA2) (LY315920–10μM), cPLA2 (AACOCF3–10μM), phospholipase C (PLC) (U73122- 10μM) and phospholipase D (PLD) (FIPI– 0.3μM) and infected with A.
Fayyaz S. Sutterwala (260673), Kari Ann Shirey (2902034), Lauren VieBrock (2902016), Michail Kotsyfakis (181487), Joao H. F. Pedra (409726), Karen M. Scanlon (2902010), Manira Rayamajhi (2902022), Dana K. Shaw (2902025), Darren J. Perkins (432774), Nicholas H. Carbonetti (224045), Thangam S. Velayutham (2902013), Sean M. Evans (2902031), Kyle G. Rodino (2902019), Edward A. Miao (631540), Jere W. McBride (207089), Holly L. Hammond (2902028), Joseph V. Bonventre (310369), Jason A. Carlyon (690352), Xiaowei Wang (27921)   +18 more
core   +1 more source

Regioselective Synthesis of 4- and 7-Alkoxyindoles from 2,3-Dihalophenols:  Application to the Preparation of Indole Inhibitors of Phospholipase A₂

, 2016
An efficient and regioselective synthesis of 4- and 7-alkoxyindoles has been developed from commercially available starting materials such as 3-halophenols and 3-chloroanisole.
Roberto Sanz (1508221), Francisco J. Fañanás (2482219), Antonio Pérez (2485648), Verónica Guilarte (2485651), M. Pilar Castroviejo (2202601)   +4 more
core   +1 more source

Functional and structural characterization of toxins from Bothrops jararacussu snake venom and influence of varespladib

, 2023
According to the World Health Organization, there are approximately 5.4 million snake bites each year, resulting in 2.7 million poisonings and 100.000 deaths.
Êmylle Karoline Ramos Pinto
core  

Molecular docking analysis of MCL-1 inhibitors for breast cancer management. [PDF]

Bioinformation, 2023
Abdulrahman A, Mohammad Azhar K, Asif Hussain A, Ali Abdullah A, Marui IS, Mohammed Hadi G, Hanan Mamdouh A, Qamre A.   +7 more
europepmc   +1 more source

The Search for Natural and Synthetic Inhibitors That Would Complement Antivenoms as Therapeutics for Snakebite Envenoming. [PDF]

Toxins (Basel), 2021
Gutiérrez JM, Albulescu LO, Clare RH, Casewell NR, Abd El-Aziz TM, Escalante T, Rucavado A.   +6 more
europepmc   +1 more source

Oral and IV Varespladib Rescue Experiments in Juvenile Pigs with Weakness Induced by Australian and Papuan Oxyuranus scutellatus Venoms. [PDF]

Toxins (Basel), 2023
Gilliam LL, Gilliam J, Samuel SP, Carter RW, Ritchey J, Bulfone T, Gutiérrez JM, Williams DJ, Durkin DM, Stephens SI, Lewin MR.   +10 more
europepmc   +1 more source

In Silico Evaluation of Quercetin Methylated Derivatives on the Interaction with Secretory Phospholipases A2 from Crotalus durissus terrificus and Bothrops jararacussu. [PDF]

Pharmaceuticals (Basel), 2023
Belchor MN, Costa CRDC, Roggero A, Moraes LLF, Samelo R, Annunciato I, de Oliveira MA, Sousa SF, Toyama MH.   +8 more
europepmc   +1 more source

In Vitro Efficacy of Antivenom and Varespladib in Neutralising Chinese Russell's Viper (Daboia siamensis) Venom Toxicity. [PDF]

Toxins (Basel), 2023
Lay M, Liang Q, Isbister GK, Hodgson WC.
europepmc   +1 more source

In Vitro Neutralization of the Myotoxicity of Australian Mulga Snake (Pseudechis australis) and Sri Lankan Russell's Viper (Daboia russelii) Venoms by Australian and Indian Polyvalent Antivenoms. [PDF]

Toxins (Basel), 2022
Thakshila P, Hodgson WC, Isbister GK, Silva A.   +3 more
europepmc   +1 more source

Quercitrin neutralizes sPLA2IIa activity, reduces the inflammatory IL-6 level in PC3 cell lines, and exhibits anti-tumor activity in the EAC-bearing mice model. [PDF]

Front Pharmacol, 2022
Sophiya P, Urs D, K Lone J, Giresha AS, Krishna Ram H, Manjunatha JG, El-Serehy HA, Narayanappa M, Shankar J, Bhardwaj R, Ahmad Guru S, Dharmappa KK.   +11 more
europepmc   +1 more source