Results 91 to 100 of about 214,299 (407)

Minimizing acetate formation in E. coli fermentations [PDF]

, 2007
Escherichia coli remains the best established production organisms in industrial biotechnology. However, during aerobic fermentation runs at high growth rates, considerable amounts of acetate are accumulated as by-product.
De Maeseneire, Sofie, De Mey, Marjan, Soetaert, Wim, Vandamme, Erick   +3 more
core   +2 more sources

Targeted H2S Delivery System Attenuates Blood‐Spinal Cord Barrier Disruption after Spinal Cord Injury by Reshaping the Ferritinophagy Pathway

Advanced Science, EarlyView.
The αvβ3‐mediated SPRC@MPDA‐RGD targets broken endothelial cells and controllably releases SPRC. CSE is then activated to produce endogenous H2S, which inhibits ferritinophagy. In brief, H2S inhibits autophagy by activating the PI3K/Akt/mTOR pathway, thereby suppressing the ferroptosis process mediated by NCOA4, and ultimately promoting the ...
Zhiheng Chen, Xinkai Pu, Ruiyang Li, Yuezhou Wu, Qirong Zhou, Jian Wang, Yuxuan Qian, Fengjie Lu, Jian‐Yuan Zhao, Zhida Su, Jiacan Su, Xiaofeng Lian   +11 more
wiley   +1 more source

Encapsulated Escherichia coli in alginate beads capable of secreting a heterologous pectin lyase

Microbial Cell Factories, 2005
Background Production of heterologous proteins in the E. coli periplasm, or into the extracellular fluid has many advantages; therefore naturally occurring signal peptides are selected for proteins translocation.
Trikka Fotini A, Chaitidou Sotiria A, Papi Rigini M, Kyriakidis Dimitrios A   +3 more
doaj   +1 more source

YsHyl8A, an Alkalophilic Cold-Adapted Glycosaminoglycan Lyase Cloned from Pathogenic Yersinia sp. 298

Molecules, 2022
A high enzyme-yield strain Yersinia sp. 298 was screened from marine bacteria harvested from the coastal water. The screening conditions were extensive, utilizing hyaluronic acid (HA)/chondroitin sulfate (CS) as the carbon source.
Shilong Zhang, Yujiao Li, Feng Han, Wengong Yu   +3 more
doaj   +1 more source

Novel Molecular Insights into the Catalytic Mechanism of Marine Bacterial Alginate Lyase AlyGC from Polysaccharide Lyase Family 6*

Journal of Biological Chemistry, 2017
Alginate lyases that degrade alginate via a β-elimination reaction fall into seven polysaccharide lyase (PL) families. Although the structures and catalytic mechanisms of alginate lyases in the other PL families have been clarified, those in family PL6 ...
Fei Xu, F. Dong, Peng Wang, H. Cao, Chunyang Li, Ping-Yi Li, Xiuhua Pang, Yu-Zhong Zhang, Xiulan Chen   +8 more
semanticscholar   +1 more source

A Microbial Lipid‐ATP Synthase Axis Fuels NK Cell Antitumor Activity

Advanced Science, EarlyView.
This study focuses on the mechanism by which gut microbiota‐derived outer membrane vesicles (OMVs) regulate NK cell antitumor activity. B. intestinalis is identified to decrease extra‐intestinal tumor growth via its OMVs enriched in sphingosine (SP).
Kaiyuan Yu, Xinyu Sun, Wanxia Ma, Jianming Yang, Xuan Sun, Lisong Zhang, Yumeng Liu, Tianshu Ren, Qi Wang, Jingyu Wang, Xiao Li, Xianping Peng, Liu Yang, Junqiang Lv, Zhi Yao, Zhi‐Song Zhang, Quan Wang   +16 more
wiley   +1 more source

The Rewiring of Ubiquitination Targets in a Pathogenic Yeast Promotes Metabolic Flexibility, Host Colonization and Virulence [PDF]

, 2016
Funding: This work was funded by the European Research Council [http://erc.europa.eu/], AJPB (STRIFE Advanced Grant; C-2009-AdG-249793). The work was also supported by: the Wellcome Trust [www.wellcome.ac.uk], AJPB (080088, 097377); the UK Biotechnology ...
A Brand, A Enache-Angoulvant, A Rodaki, A Rosenbach, AJP Brown, AJP Brown, AL Diaz-Perez, Alistair J. P. Brown, AM New, B Gorke, C Fradin, C Janke, C Taxis, CJ Barelle, CR Rocha, D Lohr, D Sandai, DA Opulente, David Stead, Delma S. Childers, DH Owen, DM MacCallum, Donna M. MacCallum, DS Childers, EJ Munoz-Elias, Elizabeth R. Ballou, F Cao, F Sherman, FC Odds, Gabriela Mol Avelar, H Holzer, H Zhou, HG Crabtree, HL Cheah, Ingrida Raziunaite, IV Ene, IV Ene, J Piskur, J Regelmann, J Shen, JA Sexton, JH Hegemann, JK Byron, JM Gancedo, Joanna Mackie, JP Barford, K Piekarska, K Ueno, M Carlson, M Hammerle, M Johnston, M Niimi, MA Navas, MA Ramirez, MC Lorenz, MC Lorenz, Megan D. Lenardon, MS Price, Neil A. R. Gow, O Santt, P Miramon, P Radivojac, PL Fidel Jr., R Menssen, R Sabouraud, R Sharma, RA Calderone, RA Calderone, Robert A. Cramer, S Funayama, Susan Budge, T Inada, T Schule, TH Rude, YS Lopez-Boado, Z Yin   +75 more
core   +4 more sources

Plant Genetic Engineering: Technological Pathways, Application Scenarios, and Future Directions

Advanced Science, EarlyView.
This review maps the fast‐evolving landscape of plant genetic engineering, linking enabling platforms with trait‐focused applications in architecture optimization, stress resilience, yield improvement, and quality enhancement. It highlights how genome editing, transgenic strategies, and emerging multi‐gene approaches reshape breeding pipelines, while ...
Peilin Wang, Wenzhi Wang, Dongjiao Wang, Qibin Wu, Youxiong Que   +4 more
wiley   +1 more source

Is acetylation a metabolic rheostat that regulates skeletal muscle insulin action? [PDF]

, 2015
Skeletal muscle insulin resistance, which increases the risk for developing various metabolic diseases, including type 2 diabetes, is a common metabolic disorder in obesity and aging.
LaBarge, Samuel, Migdal, Christopher, Schenk, Simon   +2 more
core   +2 more sources

Pneumococcal galactose catabolism is controlled by multiple regulators acting on pyruvate formate lyase

Scientific Reports, 2017
Catabolism of galactose by Streptococcus pneumoniae alters the microbe’s metabolism from homolactic to mixed acid fermentation, and this shift is linked to the microbe’s virulence. However, the genetic basis of this switch is unknown.
F. Al-Bayati, H. Kahya, Andreas C. Damianou, Sulman Shafeeq, O. Kuipers, P. Andrew, H. Yesilkaya   +6 more
semanticscholar   +1 more source