Supplementary Table and Figure from Phase I Study of Seviteronel, a Selective CYP17 Lyase and Androgen Receptor Inhibitor, in Men with Castration-Resistant Prostate Cancer [PDF]
, 2023 Shilpa Gupta +8 more
openalex +1 more source
Scientific Reports, 2018 Ulvan, which is one of the major structural polysaccharides of the cell walls of green macroalgae, is degraded by ulvan lyases via the β-elimination mechanism with the release of oligosaccharides that have unsaturated 4-deoxy-L-threo-hex-4 ...
Venkat Rao Konasani +3 more
semanticscholar +1 more source
Engineering a Virus‐Derived X Family DNA Polymerase FvPolX for de novo DNA Synthesis
Advanced Science, EarlyView.In this study, a Faustovirus‐derived polymerase (FvPolX) is engineered based on structural and sequence analysis of PolX enzymes. The optimal mutants demonstrate substantially enhanced catalytic activity toward dNTPs and 3′‐ONH2‐dNTPs compared to the wild‐type enzyme.
Chengjie Zhang, Lei Du, Shengying Li
wiley +1 more source
Shipin gongye ke-jiObjective: This study aimed to screen a strain with high alginate lyase activity, identify it, optimize the fermentation conditions, and evaluate the degradation effect on Sargassum of the strain.
Shuang LUO +8 more
doaj +1 more source
Characterization of a Novel PolyM-Preferred Alginate Lyase from Marine Vibrio splendidus OU02
Marine Drugs, 2018 Alginate lyases are enzymes that degrade alginate into oligosaccharides which possess a variety of biological activities. Discovering and characterizing novel alginate lyases has great significance for industrial and medical applications.
Jingjing Zhuang +5 more
semanticscholar +1 more source
Association of immune response with efficacy and safety outcomes in adults with phenylketonuria administered pegvaliase in phase 3 clinical trials [PDF]
, 2018 Background: This study assessed the immunogenicity of pegvaliase (recombinant Anabaena variabilis phenylalanine [Phe] ammonia lyase [PAL] conjugated with polyethylene glycol [PEG]) treatment in adults with phenylketonuria (PKU) and its impact on safety ...
Atkinson, John P +14 more
core +2 more sources
Advanced Science, EarlyView.Dysregulated TCA cycle contributes to Alzheimer's disease (AD) pathogenesis. Here, we show that microglial isocitrate dehydrogenase 1 (IDH1) is a critical driver. Elevated IDH1 disrupts citrate metabolism and mitochondrial function, exacerbating AD pathology.
Qianqian Li +13 more
wiley +1 more source
Supplementary Figure 4 from ATP Citrate Lyase Knockdown Induces Growth Arrest and Apoptosis through Different Cell- and Environment-Dependent Mechanisms [PDF]
, 2023 Nousheen Zaidi +3 more
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Selenium‐Based Nanoplatforms: An Emerging Theranostic Paradigm for Gynecological Cancers
Advanced Science, EarlyView.This reivew summarizes Selenium as a multifunctional anticancer regulator in gynecological cancers. It reduces tumor risk, enhances therapeutic efficacy, and reduces treatment toxicity. Selenium also overcomes chemoraditherapy resistance, improving overall treatment outcomes. ABSTRACT Gynecological cancers present significant therapeutic challenges due
Hejing Liu +9 more
wiley +1 more source
Screening and identification of marine alginate lyase-producing bacteria and optimization of enzyme production conditions [PDF]
Zhongguo niangzaoAlginate lyases are mostly derived from marine bacteria with unique living environments. Using sodium alginate as the sole carbon source, a strain with high-yield alginate lyase from 56 strains of marine bacteria was screened using primary screening by ...
HU Mengdi, LI Yaozu, ZHANG Xiaoyong, MO Meiqing, GAO Xiangyang
doaj +1 more source