Results 11 to 20 of about 214,299 (407)
ATP citrate lyase is increased in human breast cancer, depletion of which promotes apoptosis
Tumor Biology, 2017 Breast cancer is a malignant tumor that is harmful to women’s health around the world. Investigating the biological mechanism is, therefore, of pivotal importance to improve patients’ prognoses.
Diyu Wang +4 more
doaj +2 more sources
Acetyl-CoA-mediated activation of Mycobacterium tuberculosis isocitrate lyase 2
Nature Communications, 2019 Isocitrate lyase (ICL) isoforms 1 and 2 are enzymes in the glyoxylate and methylcitrate cycles that enable Mycobacterium tuberculosis (Mtb) to use lipids as a carbon source.
Ram Prasad Bhusal +7 more
doaj +2 more sources
Development of a versatile and efficient C-N lyase platform for asymmetric hydroamination via computational enzyme redesign [PDF]
Nature Catalysis, 2020 Although C–N bonds are ubiquitous in natural products, pharmaceuticals and agrochemicals, biocatalysts forging these bonds with high atom-efficiency and enantioselectivity have been limited to a few select enzymes.
Yinglu Cui +8 more
openalex +2 more sources
Screening of alginate lyase-excreting microorganisms from the surface of brown algae
AMB Express, 2017 Alginate lyase is a biocatalyst that degrades alginate to produce oligosaccharides, which have many bioactive functions and could be used as renewable biofuels.
Mingpeng Wang +5 more
doaj +2 more sources
Marine Drugs, 2022 Alginate oligosaccharides (AOS) have many biological activities and significant applications in prebiotics, nutritional supplements, and plant growth development. Alginate lyases have unique advantages in the preparation of AOS.
Z. Xue +7 more
semanticscholar +1 more source
Gellan lyases-novel polysaccharide lyases [PDF]
Microbiology, 1994 A number of bacterial strains capable of degrading the bacterial exopolysaccharide gellan have been isolated by standard enrichment procedures. They include several pink-pigmented Gram-negative rod-shaped bacteria. A red-pigmented Gram-positive bacillus earlier found to degrade the exopolysaccharide xanthan from Xanthomonas campestris also showed ...
L, Kennedy, I W, Sutherland
openaire +2 more sources
eLife, 2021 Dimethylsulfoniopropionate (DMSP) is an abundant and ubiquitous organosulfur molecule in marine environments with important roles in global sulfur and nutrient cycling.
Chunyang Li +17 more
semanticscholar +1 more source
Argininosuccinate lyase deficiency [PDF]
Genetics in Medicine, 2012 The urea cycle consists of six consecutive enzymatic reactions that convert waste nitrogen into urea. Deficiencies of any of these enzymes of the cycle result in urea cycle disorders (UCDs), a group of inborn errors of hepatic metabolism that often result in life-threatening hyperammonemia. Argininosuccinate lyase (ASL) catalyzes the fourth reaction in
Sandesh C S, Nagamani +2 more
openaire +2 more sources
Adenylosuccinate lyase deficiency [PDF]
Journal of Inherited Metabolic Disease, 2014 AbstractAdenylosuccinate lyase ADSL) deficiency is a defect of purine metabolism affecting purinosome assembly and reducing metabolite fluxes through purine de novo synthesis and purine nucleotide recycling pathways. Biochemically this defect manifests by the presence in the biologic fluids of two dephosphorylated substrates of ADSL enzyme ...
Jurecka, Agnieszka +3 more
openaire +2 more sources
Journal of Lipid Research, 2020 Sphingosine 1-phosphate (S1P) lyase is an intracellular enzyme that catalyzes the irreversible degradation of S1P and has been suggested as a therapeutic target for the treatment of psoriasis vulgaris. Because S1P induces differentiation of keratinocytes,
Suwon Jeon +9 more
doaj +1 more source