Adenylosuccinate lyase deficiency [PDF]
Journal of Inherited Metabolic Disease, 2014 AbstractAdenylosuccinate lyase ADSL) deficiency is a defect of purine metabolism affecting purinosome assembly and reducing metabolite fluxes through purine de novo synthesis and purine nucleotide recycling pathways. Biochemically this defect manifests by the presence in the biologic fluids of two dephosphorylated substrates of ADSL enzyme ...
Jurecka, Agnieszka +3 more
openaire +2 more sources
Cellular internalization of alpha-synuclein aggregates by cell surface heparan sulfate depends on aggregate conformation and cell type. [PDF]
, 2017 Amyloid aggregates found in the brain of patients with neurodegenerative diseases, including Alzheimer's and Parkinson's disease, are thought to spread to increasingly larger areas of the brain through a prion-like seeding mechanism.
Esko, Jeffrey D +5 more
core +2 more sources
Maize Phenylalanine Ammonia-Lyase Has Tyrosine Ammonia-Lyase Activity [PDF]
Plant Physiology, 1997 Abstract A full-length cDNA encoding phenylalanine ammonia-lyase (PAL) from Zea mays L. was isolated and the coding region was expressed in Escherichia coli as a C-terminal fusion to glutathione S-transferase. After purification by glutathione-Sepharose chromatography, the glutathione S-transferase moiety was cleaved off and the ...
J, Rösler +3 more
openaire +2 more sources
Evidence for the role of proteoglycans in cation-mediated gene transfer [PDF]
, 1996 We report evidence that gene complexes, consisting of polycations and plasmid DNA enter cells via binding to membrane-associated proteoglycans. Treatment of HeLa cells with sodium chlorate, a potent inhibitor of proteoglycan sulfation, reduced luciferase
Baldeschwieler, John D. +1 more
core +1 more source
Biocatalysis as Useful Tool in Asymmetric Synthesis: An Assessment of Recently Granted Patents (2014–2019) [PDF]
, 2019 The broad interdisciplinary nature of biocatalysis fosters innovation, as different technical fields are interconnected and synergized. A way to depict that innovation is by conducting a survey on patent activities.
Alcántara, Andrés R. +2 more
core +3 more sources
Modeling the architecture of depolymerase-containing receptor binding proteins in Klebsiella phages [PDF]
, 2019 Klebsiella pneumoniae carries a thick polysaccharide capsule. This highly variable chemical structure plays an important role in its virulence. Many Klebsiella bacteriophages recognize this capsule with a receptor binding protein (RBP) that contains a ...
Briers, Yves +3 more
core +2 more sources
Draft Genome Sequence of Botrytis cinerea BcDW1, Inoculum for Noble Rot of Grape Berries. [PDF]
, 2013 Botrytized wines are produced from grape berries infected by Botrytis cinerea under specific environmental conditions. Here, we report the draft genome sequence of B. cinerea BcDW1, a strain isolated from Sémillon grapes in Napa Valley in 1992 that ...
Allen, Greg +3 more
core +1 more source
Bacteriophage-encoded virion-associated enzymes to overcome the carbohydrate barriers during the infection process [PDF]
, 2017 Bacteriophages are bacterial viruses that infect the host after successful receptor recognition and adsorption to the cell surface. The irreversible adherence followed by genome material ejection into host cell cytoplasm must be preceded by the passage ...
Briers, Yves +4 more
core +1 more source
Postępy Higieny i Medycyny Doświadczalnej, 2014 γ-Cystathionase (CTH, EC: 4.4.1.1), an enzyme widely distributed in the world of prokaryotic and eukaryotic organisms, catalyzes the formation and transformations of sulfane sulfur-containing compounds and plays a pivotal role in the L-cysteine desulfuration pathway.
Halina, Jurkowska +3 more
openaire +2 more sources
Predictive modelling of the combined effect of temperature and water activity on the in vitro growth of Erwinia spp. infecting potato tubers in Belgium [PDF]
Biotechnologie, Agronomie, Société et Environnement, 2011 Erwinia carotovora ssp. atroseptica (Eca), Erwinia carotovora ssp. carotovora (Ecc) and Erwinia chrysanthemi (Ech), are the main cause of potato tuber decay (soft rot) in storage and stem rot in the field (blackleg). The bacteria are characterized by the
Moh, AA. +4 more
doaj