Results 1 to 10 of about 433,280 (265)
New Catalytic Residues and Catalytic Mechanism of the RNase T1 Family [PDF]
ACS Bio & Med Chem AuThe ribonuclease T1 family, including RNase Po1 secreted by Pleurotus ostreatus, exhibits antitumor activity. Here, we resolved the Po1/guanosine-3'-monophosphate complex (3'GMP) structure at 1.75 Å. Structure comparison and fragment molecular orbital (FMO) calculation between the apo form and the Po1/3'GMP complex identified Phe38, Phe40, and Glu42 as
Katsuki Takebe +9 more
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Catalytic mechanism of F1-ATPase
Biochimica Et Biophysica Acta - Bioenergetics, 1997 The structure of the core catalytic unit of ATP synthase, alpha 3 beta 3 gamma, has been determined by X-ray crystallography, revealing a roughly symmetrical arrangement of alternating alpha and beta subunits around a central cavity in which helical portions of gamma are found.
Alan E Senior, Joachim Weber
exaly +3 more sources
Structural and Functional Basis of JAMM Deubiquitinating Enzymes in Disease
Biomolecules, 2022 Deubiquitinating enzymes (DUBs) are a group of proteases that are important for maintaining cell homeostasis by regulating the balance between ubiquitination and deubiquitination.
Xin Pan +5 more
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Marine Drugs, 2021 Recent explorations of tool-like alginate lyases have been focused on their oligosaccharide-yielding properties and corresponding mechanisms, whereas most were reported as endo-type with α-L-guluronate (G) preference.
Lianghuan Zeng +6 more
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Evolution of a Catalytic Mechanism [PDF]
Molecular Biology and Evolution, 2015 The means by which superfamilies of specialized enzymes arise by gene duplication and functional divergence are poorly understood. The escape from adaptive conflict hypothesis, which posits multiple copies of a gene encoding a primitive inefficient and highly promiscuous generalist ancestor, receives support from experiments showing that resurrected ...
Alissa, Rauwerdink +8 more
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Research Progress on Preparation of Marine Oligosaccharides by Enzymatic Method
Shipin gongye ke-ji, 2023 Marine oligosaccharides, which are prepared by degradation of marine polysaccharides, are carbohydrate compounds composed of two to ten monosaccharide residues.
Zixiang YANG +9 more
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Catalytic mechanisms for phosphotriesterases [PDF]
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2013 Phosphotriesters are one class of highly toxic synthetic compounds known as organophosphates. Wide spread usage of organophosphates as insecticides as well as nerve agents has lead to numerous efforts to identify enzymes capable of detoxifying them. A wide array of enzymes has been found to have phosphotriesterase activity including phosphotriesterase (
Andrew N, Bigley, Frank M, Raushel
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Recent Advances and Promises in Nitrile Hydratase: From Mechanism to Industrial Applications
Frontiers in Bioengineering and Biotechnology, 2020 Nitrile hydratase (NHase, EC 4.2.1.84) is one type of metalloenzyme participating in the biotransformation of nitriles into amides. Given its catalytic specificity in amide production and eco-friendliness, NHase has overwhelmed its chemical counterpart ...
Zhongyi Cheng, Yuanyuan Xia, Zhemin Zhou
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eLife, 2020 Synaptojanin1 (Synj1) is a phosphoinositide phosphatase, important in clathrin uncoating during endocytosis of presynaptic vesicles. It was identified as a potential drug target for Alzheimer’s disease, Down syndrome, and TBC1D24-associated epilepsy ...
Jone Paesmans +10 more
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Advanced Science, 2021 Shifting electrochemical oxygen reduction reaction (ORR) via two‐electron pathway becomes increasingly crucial as an alternative/green method for hydrogen peroxide (H2O2) generation. Here, the development of 2e− ORR catalysts in recent years is reviewed,
Nan Wang +4 more
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