Results 11 to 20 of about 850,147 (309)

Representing Catalytic Mechanisms with Rule Composition

Journal of Chemical Information and Modeling, 2022
Preprint
Jakob L. Andersen, Rolf Fagerberg, Christoph Flamm, Walter Fontana, Juri Kolčák, Christophe V.F.P. Laurent, Daniel Merkle, Nikolai Nøjgaard   +7 more
openaire   +6 more sources

Co-Catalytic Metallopeptidases as Pharmaceutical Targets [PDF]

, 2003
Understanding the reaction mechanism of co-catalytic metallopeptidases provides a starting point for the design and synthesis of new molecules that can be screened as potential pharmaceuticals. Many of the enzymes that contain co-catalytic metallo-active
Bzymek, Krzysztof P., Holz, Richard C., Swierczek, Sabina I.   +2 more
core   +2 more sources

Structural and Mechanistic Insights Into Dimethylsulfoxide Formation Through Dimethylsulfide Oxidation

Frontiers in Microbiology, 2021
Dimethylsulfide (DMS) and dimethylsulfoxide (DMSO) are widespread in marine environment, and are important participants in the global sulfur cycle. Microbiol oxidation of DMS to DMSO represents a major sink of DMS in marine surface waters.
Xiu-Juan Wang, Xiu-Juan Wang, Xiu-Juan Wang, Nan Zhang, Zhao-Jie Teng, Peng Wang, Peng Wang, Wei-Peng Zhang, Xiu-Lan Chen, Xiu-Lan Chen, Yu-Zhong Zhang, Yu-Zhong Zhang, Yu-Zhong Zhang, Yin Chen, Yin Chen, Hui-Hui Fu, Chun-Yang Li, Chun-Yang Li   +17 more
doaj   +1 more source

Catalysis by hen egg-white lysozyme proceeds via a covalent intermediate [PDF]

, 2001
Hen egg-white lysozyme (HEWL) was the first enzyme to have its three-dimensional structure determined by X-ray diffraction techniques(1). A catalytic mechanism, featuring a long-lived oxo-carbenium-ion intermediate, was proposed on the basis of model ...
A Federov, AL Fink, AT Brünger, BA Malcolm, BL Mark, CC Blake, Collaborative Computational Project Number 4, DC Phillips, DE Koshland, DM Chipman, E Holler, FW Ballardie, FW Dahlquist, G Sulzenbacher, GJ Davies, GJ Davies, GN Murshodov, I Matsumura, I Tews, ML Sinnott, NCJ Strynadka, Q Wang, R Kuroki, S Rosenberg, T Rand-Meir, TL Amyes, V Notenboom, WP Burmeister, Z Otwinowski   +28 more
core   +1 more source

Glycoside Hydrolase Family 48 Cellulase: A Key Player in Cellulolytic Bacteria for Lignocellulose Biorefinery

Fermentation, 2023
Cellulases from glycoside hydrolase family 48 (GH48) are critical components of natural lignocellulose-degrading systems. GH48 cellulases are broadly distributed in cellulolytic microorganisms.
Cai You, Ya-Jun Liu, Qiu Cui, Yingang Feng   +3 more
doaj   +1 more source

A structural and biochemical model of processive chitin synthesis [PDF]

, 2014
Chitin synthases (CHS) produce chitin, an essential component of the fungal cell wall. The molecular mechanism of processive chitin synthesis is not understood, limiting the discovery of new inhibitors of this enzyme class.
Andrew T. Ferenbach, Atkinson, Barny, Bond, Bowen, Cabib, Charnock, Coutinho, D'Haeze, Daan M.F. van Aalten, Debellé, Drew, Gaughran, Helge C. Dorfmueller, Imai, Kamst, Kamst, Kamst, Karnezis, Kathiravan, Källberg, Manoil, Martínez-Rucobo, Masubuchi, Mavingui, Morgan, Nagahashi, Orlean, Rao, Ruiz-Herrera, Semino, Shaw, Streng, Sudoh, Thompson, Uchida, Vladimir S. Borodkin, Xie, Yabe   +38 more
core   +3 more sources

Substrate specificity provides insights into the sugar donor recognition mechanism of O-GlcNAc transferase (OGT). [PDF]

, 2013
O-Linked β-N-acetylglucosaminyl transferase (OGT) plays an important role in the glycosylation of proteins, which is involved in various cellular events.
Chen, Xi, Chen, Yi, Li, Lei, Liu, Pi, Liu, Xiaoyan, Ma, Xiaofeng, Muthana, Musleh M, Sun, Hong, Wang, Peng G, Yan, Hui, Zhang, Lianwen, Zhou, Feng   +11 more
core   +6 more sources

Molecular Insight into the Acryloyl-CoA Hydration by AcuH for Acrylate Detoxification in Dimethylsulfoniopropionate-Catabolizing Bacteria

Frontiers in Microbiology, 2017
Microbial cleavage of dimethylsulfoniopropionate (DMSP) producing dimethyl sulfide (DMS) and acrylate is an important step in global sulfur cycling. Acrylate is toxic for cells, and thus should be metabolized effectively for detoxification. There are two
Hai-Yan Cao, Peng Wang, Fei Xu, Ping-Yi Li, Bin-Bin Xie, Qi-Long Qin, Yu-Zhong Zhang, Yu-Zhong Zhang, Chun-Yang Li, Xiu-Lan Chen   +9 more
doaj   +1 more source

UDP-Glycosyltransferases in Edible Fungi: Function, Structure, and Catalytic Mechanism

Fermentation, 2023
UDP-glycosyltransferases (UGTs) are the most studied glycosyltransferases, and belong to large GT1 family performing the key roles in antibiotic synthesis, the development of bacterial glycosyltransferase inhibitors, and in animal inflammation.
Yumeng Yang, Yingying Liang, Fengjie Cui, Yongli Wang, Lei Sun, Xinyi Zan, Wenjing Sun   +6 more
doaj   +1 more source

Catalytic mechanism of thioltransferase

Journal of Biological Chemistry, 1991
To evaluate potential catalytic mechanism for thioltransferase thiol-disulfide exchange reactions, seven pig liver mutants were constructed by site-directed mutagenesis. All the expressed enzymes, including wild-type and mutants with the exception of the inactive mutant, ETT-C22S, were variably inhibited by iodoacetamide, and similar results were ...
Y F, Yang, W W, Wells
openaire   +2 more sources