From data to discovery: leveraging big data in plant natural products biosynthesis research
The Plant Journal, Volume 122, Issue 6, June 2025.SUMMARY Plant natural products or specialized metabolites play a vital role in drug discovery and development, with many clinically important derivatives such as the anticancer drugs topotecan (derived from the natural alkaloid camptothecin) and etoposide (derived from the natural polyphenol podophyllotoxin).
Matthew McConnachie +4 more
wiley +1 more source
In Memoriam: The Life and Scientific Accomplishments of Frank A. L. Anet (1926–2024)
Journal of Physical Organic Chemistry, Volume 37, Issue 12, December 2024.A memorial review and tribute detailing the life and scientific accomplishments of Frank A. L. Anet, a pioneer of NMR spectroscopy who discovered bedrock principles in organic chemistry and magnetic resonance. ABSTRACT A memorial tribute detailing the life and scientific accomplishments of Frank A. L. Anet, a pioneer of nuclear magnetic resonance (NMR)
Darón I. Freedberg +4 more
wiley +1 more source
The genomic and enzymatic basis for iridoid biosynthesis in cat thyme (Teucrium marum)
The Plant Journal, Volume 118, Issue 5, Page 1589-1602, June 2024.SUMMARY Iridoids are non‐canonical monoterpenoids produced by both insects and plants. An example is the cat‐attracting and insect‐repelling volatile iridoid nepetalactone, produced by Nepeta sp. (catmint) and aphids. Recently, both nepetalactone biosynthetic pathways were elucidated, showing a remarkable convergent evolution. The iridoid, dolichodial,
Samuel J. Smit +8 more
wiley +1 more source
Total Synthesis of the Myrioneuron Alkaloid (−)‐Schoberine B and Its Enantiomer (+)‐Schoberine B
Advanced Synthesis &Catalysis, Volume 366, Issue 4, Page 948-954, February 20, 2024.Abstract A dynamic kinetic asymmetric transformation, involving the generation of four stereogenic centers with a well‐defined configuration, occurs in the cyclocondensation of diastereomeric mixtures of 2‐oxocyclohexanepropionic acid racemates 6 with (1S,2R)‐cis‐aminoindanol: two major tetracyclic lactams, 7 a and 7 b, that differ in the configuration
Arnau Calbó +3 more
wiley +1 more source
Components and Anti-HepG2 Activity Comparison of Lycopodium Alkaloids from Four Geographic Origins. [PDF]
Evid Based Complement Alternat Med, 2016 Tian YQ, Hu GW, Guo MQ.
europepmc +1 more source
Carinatines A and B, Lycopodium Alkaloids from Phlegmariurus carinatus. [PDF]
Nat Prod Bioprospect, 2014 Liu F +8 more
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Effect of protic additives in Cu-catalysed asymmetric Diels-Alder cycloadditions of doubly activated dienophiles: towards the synthesis of magellanine-type Lycopodium alkaloids. [PDF]
Chem Commun (Camb), 2017 Lindsay VNG, Murphy RA, Sarpong R.
europepmc +1 more source
Direct methoxypyridine functionalization approach to magellanine-type Lycopodium alkaloids. [PDF]
Org Lett, 2012 Murphy RA, Sarpong R.
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Plant carbonic anhydrase-like enzymes in neuroactive alkaloid biosynthesis. [PDF]
Nature, 2023 Nett RS +6 more
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Deconstructive and Divergent Synthesis of Bioactive Natural Products. [PDF]
Molecules, 2023 Hou SH, Zhou FF, Sun YH, Li QZ.
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