Results 261 to 270 of about 2,097,175 (381)

Targeting Intratumoral Copper Inhibits Tumor Progression via p62‐Mediated EZH2 Degradation and Potentiates Anti‐PD‐1 Immunotherapy in Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
The authors find that by targeting intratumoral copper, they can enhance p62‐mediated ubiquitination of EZH2 at the Ub‐K63 site by suppressing copper binding to SMURF2, an E3 ligase of EZH2, leading to its autophagic degradation. This mechanism suppressed OSCC progression and potentiated anti‐PD‐1 immunotherapy, highlighting a potential new therapeutic
Xiaohu Lin, Wanling Chen, Bo Li, Zhang Zhao, Zhonglin Yu, Xu‐Yun Zhao, Xuan Zhou, Zhien Feng, Chengzhong Lin, Wei Cao   +9 more
wiley   +1 more source

Lymph Node Yield and Lymph Node Ratio for Prognosis of Long-Term Survival in Gastric Carcinoma. [PDF]

Cancers (Basel)
Jannasch O, Schwanz M, Otto R, Mik M, Lippert H, Mroczkowski P.   +5 more
europepmc   +1 more source

Observations on the Mechanism of Secretion of γ-Globulins by Isolated Lymph Node Cells

, 1962
Ernst Helmreich, Milton Kern, Herman N. Eisen   +2 more
openalex   +1 more source

Integrated Transcriptome and Metabolomics Analyses Show MYC as a Potential Therapeutic Target for Behçet's Uveitis

Advanced Science, EarlyView.
Integrated single‐cell transcriptomic and metabolomic analyses reveal that MYC‐driven glycolysis activates the PI3K‐AKT‐FOXO1 pathway, disrupting Th17/Treg balance and promoting uveitis. MYC inhibition restores immune homeostasis and alleviates disease symptoms.
He Li, Lei Zhu, Zhaohuai Li, Yihan Zhang, Genxian Zhang, Xuening Peng, Dongting Wu, Qi Jiang, Rong Wang, Renbing Jia, Song Guo Zheng, Wenru Su   +11 more
wiley   +1 more source

Rare paracholedochal lymph node metastasis in lung cancer. [PDF]

J Surg Case Rep
Marín-Cuartas T, Ritz JP, Getz A, Wöhlke M, Sporn J.   +4 more
europepmc   +1 more source

MTCH2 Deficiency Promotes E2F4/TFRC‐Mediated Ferroptosis and Sensitizes Colorectal Cancer Liver Metastasis to Sorafenib

Advanced Science, EarlyView.
This study identifies MTCH2 as a crucial regulator of ferroptosis in colorectal cancer (CRC) progression. High expression of MTCH2 is correlated with poor prognosis in CRC patients. Furthermore, MTCH2 depletion induces ferroptosis to suppress CRC liver metastasis via the E2F4/TFRC axis and sensitizes tumors to sorafenib treatment, supporting MTCH2 as a
Pu Xing, Jiangbo Chen, Hao Hao, Xiaowen Qiao, Xinying Yang, Kai Weng, Jie Chen, Lin Song, Tianqi Liu, Yifan Hou, Tongkun Song, Yumeng Ran, Bo Chen, Hong Yang, Wei Zhao, Zaozao Wang, Jiabo Di, Beihai Jiang, Xiangqian Su   +18 more
wiley   +1 more source

Molecular profiling of primary renal marginal zone lymphoma reveals overlapping features with extranodal marginal zone lymphoma

Blood Advances
Axel Künstner, Vera von Kopylow, Philipp Lohneis, Matthias Kümmel, Hanno M. Witte, Veronica Bernard, Stephanie Stölting, Kathrin Kusch, Sivahari Gorantla, Manuela Krokowski, Nikolas von Bubnoff, Hartmut Merz, Hauke Busch, Alfred C. Feller, Niklas Gebauer   +14 more
doaj  

Body mass index is not associated with lymph node metastasis, infection, and seroma after sentinel lymph node biopsy in cutaneous melanoma. [PDF]

JAAD Int
Abu Rached N, Leifeld F, Stockfleth E, Myszkowski D, Haven Y, Bechara FG, Gambichler T.   +6 more
europepmc   +1 more source

Structure-based programming of lymph-node targeting in molecular vaccines

Nature, 2014
Haipeng Liu, K. Moynihan, Yiran Zheng, G. Szeto, Adrienne V. Li, Bonnie Huang, Debra S. Van Egeren, Clara Park, D. Irvine   +8 more
semanticscholar   +1 more source

Synthesis and Secretion of γ-Globulin by Lymph Node Cells

, 1967
Robert M. Swenson, Milton Kern
openalex   +1 more source