Results 171 to 180 of about 88,079 (354)

ETV1 Drives CD4+ T Cell‐Mediated Intestinal Inflammation in Inflammatory Bowel Disease Through Amino Acid Transporter Slc7a5

Advanced Science, EarlyView.
This study identifies the transcription factor ETV1 as a key driver of CD4⁺ T cell‐mediated intestinal inflammation in inflammatory bowel disease (IBD). ETV1 promotes CD4⁺ T cell activation, proliferation, and Th17 differentiation by activating the amino acid transporter SLC7A5, fueling metabolic reprogramming.
Yan Shi, Song Wang, Yuqing Yan, Wei Chen, Yingying Cao, Dafan Chen, Wei Chen, Caiyun Ma, Xinjian Wan   +8 more
wiley   +1 more source

Notch2 Directs aTreg Cell Fate toward Immunoregulation or Inflammatory Pyroptosis

Advanced Science, EarlyView.
Schematic illustration showing that the Notch2 intracellular domain (NICD2) facilitates pyroptosis resistance in activated Tregs through the RREB1/Foxo1 signaling pathway. In addition, Notch2‐mediated pyroptosis resistance in activated Tregs promotes immunoregulatory capacity, thereby attenuating Th2‐driven inflammatory responses in allergic rhinitis ...
Yue‐Long Qiao, Shan Xu, You Zou, Rui Yang, Han Zheng, Jia‐Yu Liu, Hui‐Ming Fan, Yuan‐Yuan Zhang, Yong‐Gang Kong, Wo‐Er Jiao, Shi‐Ming Chen   +10 more
wiley   +1 more source

Lipid‐Driven OLR1/FOXM1/FGF19 Axis Orchestrates Crosstalk in an Epithelial‐Fibroblast Positive Feedback Promoting Progesterone Resistance in Endometrial Cancer

Advanced Science, EarlyView.
It is revealed that a metabolic–stromal loop driven by oxLDL–OLR1–FOXM1–FGF19 signaling promotes progesterone resistance in endometrial cancer. OxLDL activates epithelial–fibroblast crosstalk, enhancing proliferation and hormonal insensitivity. Disruption of this circuit, especially with resveratrol, restores MPA sensitivity, highlighting a potential ...
Xingchen Li, Yue Qi, Yuman Wu, Xinyi Bi, Yiqin Wang, Jiaqi Wang, Jingyuan Wang, Lingpu Zhang, Haihua Xiao, Jianliu Wang   +9 more
wiley   +1 more source

Frequency of Occult Residual Melanoma After Excision of a Clinically Positive Regional Lymph Node

, 1987
Michael P. Kane, Edward F. McClay, Robert E. Bellet   +2 more
openalex   +2 more sources

Nanoparticle Adjuvant Design Enhances Germinal Center Responses Targeting Conserved Subdominant Epitopes for Pan‐Coronavirus Vaccine Development

Advanced Science, EarlyView.
Current SARS‐CoV‐2 vaccines generate short‐lived, strain‐specific immunity. A polymeric TLR7 agonist nanoparticle (TLR7‐NP) adjuvant enhances lymph node targeting and promotes early and sustained germinal center responses toward conserved S2 epitopes of the spike protein.
Sijin Huang, Kanella M. Cohen, Liqiang Chen, Xiaowo Kang, Chang Liu, Megan E. Demouth, Wenxia Jiang, Alexander R. Maldeney, Rong Tong, Zunlong Ke, Kartik Chandran, Wei Luo, Qian Yin   +12 more
wiley   +1 more source

Prognostic value of lymph node metastases of differentiated thyroid cancer (DTC) according to the local advancement and range of surgical excision [PDF]

, 2010
Agnieszka Czarniecka, Michał Jarząb, Jolanta Krajewska, Ewa Chmielik, Bogna Szcześniak-Kłusek, Ewa Stobiecka, Robert Kokot, Aleksander Sacher, Stanisław Półtorak, Jan Włoch   +9 more
openalex   +1 more source

Lymph node excisions provide more precise lymphoma diagnoses than core biopsies: a French Lymphopath network survey [PDF]

, 2022
Charlotte Syrykh, Charlotte Chaouat, Elsa Poullot, Nadia Amara, Virginie Fataccioli, Marie Parrens, Alexandra Traverse‐Glehen, Thierry Jo Molina, Luc Xerri, Laurent Martin, Romain Dubois, Vanessa Szablewski, Marie‐Christine Copin, Philippe Moreau, Marie‐Pierre Chenard, Bastien Cabarrou, Amélie Lusque, Philippe Gaulard, Pierre Brousset, Camille Laurent   +19 more
openalex   +1 more source

A Microbiota‐ and IL‐15‐Dependent Innate‐Like B Cell Progenitor Expressing E4BP4

Advanced Science, EarlyView.
This work identifies CD3.NKp46.CD19.NK1.1. NK‐B cells enriched in PDK1‐deficient yet present in wild‐type bone marrow. IL‐15 (via CD122) and TLR9‐microbiota signaling maintain their E4BP4 expression. These cells demonstrate innate immunity, preferentially differentiate into B cells, and unveil a novel microbiota‐ and IL‐15‐dependent regulatory pathway ...
Junming He, Xinlei Hou, Xiaomei Feng, Yayun Dong, Mengqi Ren, Surong Deng, Xinru Yang, Donglin Chen, Lingna Zhao, Shasha Chen, Meixiang Yang, Zhongjun Dong   +11 more
wiley   +1 more source

The diagnostic pathway to lymph node excision biopsy in an HIV- and tuberculosis-endemic region. [PDF]

South Afr J HIV Med
Potelwa C, Gray S, Malherbe F, Kloppers C, Richardson D, Bailey J, Brown K, Verburgh E.   +7 more
europepmc   +1 more source

Primary invasive lobular carcinoma arising in mammary‐like glands of the vulva managed with neoadjuvant trastuzumab‐based chemotherapy, excision, and sentinel lymph node biopsy [PDF]

, 2020
Shiva Niakan, Heather Love, Qing Cao, Nada Kawar   +3 more
openalex   +1 more source