Results 141 to 150 of about 18,997 (178)

Cytokines regulating lymphangiogenesis

Current Opinion in Immunology, 2018
Lymphatic vessels are established by differentiation of lymphendothelial progenitors during embryogenesis. Lymphangiogenesis, the formation of new lymphatic vessels from pre-existing ones is rare in the healthy adult but takes place during pathological conditions such as inflammation, tissue repair and tumor growth.
Miguel, Sáinz-Jaspeado, Lena, Claesson-Welsh   +1 more
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Molecular Mechanisms of Lymphangiogenesis

International Journal of Hematology, 2004
Although the process of vascular development has been well documented, little is understood about lymphatic vasculature formation, despite its importance in normal and pathologic conditions. The dysfunction or abnormal growth of lymphatic vessels is associated with lymphedema and cancer metastasis. The recent discovery of lymphangiogenic growth factors
Meiko, Takahashi, Takanobu, Yoshimoto, Hajime, Kubo   +2 more
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Inflammatory Triggers of Lymphangiogenesis

Lymphatic Research and Biology, 2003
Inflammation is the common denominator to the postnatal events that overlap with lymphatic vessel growth, or lymphangiogenesis. Undoubtedly, inflammation and accompanying fluid overload are cardinal factors in wound healing, lymphedema, the pathogenesis of some forms of lymphangiomatosis, and solid tumor lymphangiogenesis.
Carla, Mouta, Mélanie, Heroult
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Role of Lymphangiogenesis in Cancer

Journal of Clinical Oncology, 2007
Regional lymph node metastasis is a common event in solid tumors and is considered a marker for dissemination, increased stage, and worse prognosis. Despite rapid advances in tumor biology, the molecular processes that underpin lymphatic invasion and lymph node metastasis remain poorly understood.
Sudha S, Sundar, Trivadi S, Ganesan
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Signaling angiogenesis and lymphangiogenesis

Current Opinion in Cell Biology, 1998
Exciting progress has been made in elucidating the complex network of receptor-ligand interactions that regulate blood vessel growth. Understanding these control mechanisms is of interest not only because of their role in developmental biology, but because they provide potential therapeutic strategies for disease processes involving angiogenesis, such ...
E I, Korpelainen, K, Alitalo
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Molecular control of lymphangiogenesis

BioEssays, 2002
AbstractThe lymphatic vasculature plays a critical role in the regulation of body fluid volume and immune function. Extensive research into the molecular mechanisms that control blood vessel growth has led to identification of molecules that also regulate development and growth of the lymphatic vessels.
Megan E, Baldwin, Steven A, Stacker, Marc G, Achen   +2 more
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Lymphangiogenesis

Archives of Dermatology, 2008
Vernon K. Sondak, Jane L. Messina
  +4 more sources

Lymphangiogenesis and cancer metastasis

Nature Reviews Cancer, 2002
Lymphatic vessels are important for the spread of solid tumours, but the mechanisms that underlie lymphatic spread and the role of lymphangiogenesis (the growth of lymphatics) in tumour metastasis has been less clear. This article reviews recent experimental and clinico-pathological data indicating that growth factors that stimulate lymphangiogenesis ...
Steven A, Stacker, Marc G, Achen, Lotta, Jussila, Megan E, Baldwin, Kari, Alitalo   +4 more
openaire   +2 more sources

Molecular Regulation of Lymphangiogenesis

Annals of the New York Academy of Sciences, 2004
Abstract: The lymphatic vascular system is necessary for the return of extravasated interstitial fluid and macromolecules to the blood circulation, for immune defense, and for the uptake of dietary fats. Impaired functioning of lymphatic vessels results in lymphedema, whereas tumor‐associated lymphangiogenesis may contribute to the spread of cancer ...
Pipsa, Saharinen, Tatiana V, Petrova
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Lymphangiogenesis New Mechanisms

Annals of the New York Academy of Sciences, 2002
Abstract: A mouse model has been developed to study lymphangiogenesis dissociated from angiogenesis. bFGF implanted in a mouse cornea at a concentration below the threshold to induce angiogenesis potently induces lymphangiogenesis. This model has permitted a study of cellular and molecular mechanisms of lymphangiogenesis.
Lynn, Chang, Arja, Kaipainen, Judah, Folkman   +2 more
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