Results 121 to 130 of about 33,655 (235)

Expression and Prognostic Value of VEGF-C and Lymphangeogenesis 
in Lung Adenocarcinoma and Squamous Cell Carcinoma

Chinese Journal of Lung Cancer, 2011
Background and objective Vascular endothelial growth factor-C (VEGF-C), a member of the VEGF family, has been proven to be a relatively special VEGF. When binding to its receptor VEGFR-3, it activates lymphangiogenesis, which likely induces lymph node ...
Xueli DAI, Wenli WANG, Yang SHEN-TU, Jie ZHANG   +3 more
doaj   +1 more source

Role of Lymphatic Vessels in Tumor Immunity: Passive Conduits or Active Participants? [PDF]

, 2018
Research in lymphatic biology and cancer immunology may soon intersect as emerging evidence implicates the lymphatics in the progression of chronic inflammation and autoimmunity as well as in tumor metastasis and immune escape. Like the blood vasculature,
Lund, Amanda, Swartz, Melody
core  

Cyclooxygenase‐2 (COX‐2) as a Potential Prognostic Marker in Oral Squamous Cell Carcinoma: A Systematic Review and Meta‐Analysis

Health Science Reports, Volume 9, Issue 4, April 2026.
ABSTRACT Background and Aims Oral squamous cell carcinoma (OSCC) is the predominant form of head and neck squamous cell carcinoma (HNSCC), accounting for most cancer‐related deaths due to metastasis and recurrence. COX‐2, an inflammatory biomarker encoded by prostaglandin‐endoperoxide synthase 2 (PTGS2) gene, has been shown to play a significant role ...
Hanan M. Qasem, Ramez M. Odat, Sakhr Alshwayyat, Osama M. Younis, Jehad A. Yasin, Ayham Mohammad Hussein, Bara M. Hammadeh, Majed Ghlailat, Lujain Al Amayreh, Rukesh Yadav, Dang Nguyen, Hritvik Jain, Raveena Kelkar   +12 more
wiley   +1 more source

Lymphatic‐specific methyltransferase‐like 3‐mediated m6A modification drives vascular patterning through prostaglandin metabolism reprogramming

MedComm
Lymphangiogenesis plays a pivotal role in the pathogenesis of various vascular disorders, including ocular vascular diseases and cancers. Deregulation of N6‐methyladenosine (m6A) modification has been identified as a key contributor to human diseases ...
Lianjun Shi, Shuting Lu, Xue Han, Fan Ye, Xiumiao Li, Ziran Zhang, Qin Jiang, Biao Yan   +7 more
doaj   +1 more source

Lymphatics and Lymphangiogenesis in the Eye

Journal of Ophthalmology, 2012
Lymphatic is a prerequisite for the maintenance of tissue fluid balance and immunity in the body. A body of evidence also shows that lymphangiogenesis plays important roles in the pathogenesis of diseases such as tumor metastasis and inflammation.
Shintaro Nakao, Ali Hafezi-Moghadam, Tatsuro Ishibashi   +2 more
doaj   +1 more source

Tumor-induced lymphangiogenesis in cervical lymph nodes in oral melanoma-bearing mice

Journal of Experimental & Clinical Cancer Research, 2012
Background Metastasis via the lymphatic system is promoted by lymphangiogenesis. Alterations of the lymphatic channels during the progression of metastasis to regional lymph nodes (LNs) remain unexplored.
Ozasa Ryuki, Ohno Jun, Iwahashi Teruaki, Taniguchi Kunihisa   +3 more
doaj   +1 more source

The Homeobox Genes: Classification, Regulation, Biological Functions, and Diseases

MedComm, Volume 7, Issue 4, April 2026.
Overview of the homeobox gene superfamily and its pathophysiological roles. The homeobox superfamily comprises several major classes, including ANTP, PRD, TALE, LIM, POU, and others. Among these, the HOX clusters (A–D) play critical roles in embryonic development specifically in conferring cellular identity, regulating morphogenesis, and guiding axial ...
Maedeh Dadzadi, Shahin Ramazi, Mona Darvazi, Sepideh Yoosefi, Melika Abbasi, Shirin Farsad   +5 more
wiley   +1 more source

The global landscape and research trend of lymphangiogenesis in breast cancer: a bibliometric analysis and visualization

Frontiers in Oncology
BackgroundBreast cancer persists as a major public health issue on a global scale. Lymphangiogenesis is an indispensable element in the promotion of breast cancer metastasis.
Liuyan Xu, Xuan Wang, Beibei Wang, Bingxin Meng, Xiaohua Pei   +4 more
doaj   +1 more source

AI‐assisted design of a VEGFR2 agonistic peptide that promotes angiogenesis and wound repair

Protein Science, Volume 35, Issue 4, April 2026.
Abstract Vascular endothelial growth factor (VEGF) serves as a principal regulator of neovascularization and is essential for vascular regeneration. In this study, we identified and evaluated VEGF Mimetic Peptide3 (VMP3), a novel synthetic peptide developed as a potential VEGFR‐2/VEGF‐A modulator.
Farzana Yasmeen, Rajath Ramachandran, Rameez Hassan Pirzada, Bogeum Choi, Hana Seo, Wook Kim, Moon Suk Kim, Sangdun Choi   +7 more
wiley   +1 more source

Impact of Sequential Ramucirumab Plus Docetaxel After PD‐1 Inhibitors on Anti‐PD‐1 Antibody‐Bound T‐Cell Dynamics and Clinical Outcomes

Cancer Science, Volume 117, Issue 4, Page 929-942, April 2026.
Ramucirumab (RAM) plus docetaxel (DOC) after PD‐1 inhibitors showed clinical activity, with responders exhibiting maintained anti–PD‐1 (IgG4+)‐bound CD8+ T cells and decreased IgG4+ Tregs. A sequential strategy of administering RAM plus DOC during persistent anti–PD‐1 antibody binding may be beneficial in patients with advanced non‐small cell lung ...
Kinnosuke Matsumoto, Yujiro Naito, Takayuki Shiroyama, Motohiro Tamiya, Kazumi Nishino, Akihiro Tamiya, Kyoichi Okishio, Yuhei Kinehara, Tomoki Kuge, Masahide Mori, Shingo Satoh, Hidekazu Suzuki, Satoshi Tetsumoto, Toshie Niki, Yasuhiko Suga, Akio Osa, Toshiyuki Minami, Shohei Koyama, Yoshito Takeda, Nobuyuki Takakura, Atsushi Kumanogoh   +20 more
wiley   +1 more source