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Lymphangiogenesis and cancer metastasis
Nature Reviews Cancer, 2002Lymphatic vessels are important for the spread of solid tumours, but the mechanisms that underlie lymphatic spread and the role of lymphangiogenesis (the growth of lymphatics) in tumour metastasis has been less clear. This article reviews recent experimental and clinico-pathological data indicating that growth factors that stimulate lymphangiogenesis ...
Steven A, Stacker +4 more
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Molecular Regulation of Lymphangiogenesis
Annals of the New York Academy of Sciences, 2004Abstract: The lymphatic vascular system is necessary for the return of extravasated interstitial fluid and macromolecules to the blood circulation, for immune defense, and for the uptake of dietary fats. Impaired functioning of lymphatic vessels results in lymphedema, whereas tumor‐associated lymphangiogenesis may contribute to the spread of cancer ...
Pipsa, Saharinen, Tatiana V, Petrova
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Mouse corneal lymphangiogenesis model
Nature Protocols, 2011This protocol describes a powerful in vivo method to quantitatively study the formation of new lymphatic vessels in the avascular cornea without interference of pre-existing lymphatics. Implantation of 100 ng of lymphangiogenic factors such as vascular endothelial growth factor (VEGF)-A, VEGF-C or fibroblast growth factor-2, together with slow-release ...
Cao, Renhai +7 more
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Molecular control of lymphangiogenesis
BioEssays, 2002AbstractThe lymphatic vasculature plays a critical role in the regulation of body fluid volume and immune function. Extensive research into the molecular mechanisms that control blood vessel growth has led to identification of molecules that also regulate development and growth of the lymphatic vessels.
Megan E, Baldwin +2 more
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Historical overview of lymphangiogenesis
Current Opinion in Immunology, 2018The investigation of the lymphatic system has a very long and intriguing history, with several medical figures which brought important contributions. Work on the lymphatic system began in the 17th century, and by the beginning of the 19th century the anatomy of most of the lymphatic system had been described.
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A Fisheye View on Lymphangiogenesis
2013Zebrafish have been widely used to study vasculogenesis and angiogenesis, and the vascular system is one of the most intensively studied organ systems in teleosts. It is a little surprising, therefore, that the development of the zebrafish lymphatic network has only been investigated in any detail for less than a decade now.
van Impel, Andreas +1 more
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Molecular regulation of angiogenesis and lymphangiogenesis
Nature reviews. Molecular cell biology, 2007R. Adams, K. Alitalo
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