Results 81 to 90 of about 26,475 (231)
Stem Cell‐Based Approaches for Neurotrophic Keratopathy: From Ocular Surface to Neuro‐Ophthalmology
Sensory Neuroscience, EarlyView.ABSTRACT Neurotrophic keratopathy is an uncommon, but potentially sight‐threatening, corneal disorder that results from impaired trigeminal sensory innervation. The loss of corneal sensation disrupts epithelial stability, weakens wound healing, and may lead to persistent epithelial defects, stromal ulceration, and, in the most advanced cases, corneal ...
Matteo Capobianco, Marco Zeppieri
wiley +1 more source
Corneal transplantation: Restoring sight to the blind
Acta Ophthalmologica, EarlyView.Abstract Corneal blindness is one of the leading causes of vision loss worldwide. Transplantation of the cornea can restore vision and make blind patients see again. Corneal transplant surgery has undergone major evolution in recent decades with the advent of minimally invasive lamellar surgical approaches such as DMEK and DALK.
Claus Cursiefen
wiley +1 more source
Cell Transplantation, 2022 Extracellular vesicles from adipose-derived mesenchymal stem cells (ADSCs) play an important role in lymphangiogenesis; however, the underlying mechanisms are not fully understood.
Yi Yang +8 more
doaj +1 more source
New perspectives on VEGF signalling in Alzheimer's disease
Brain Pathology, EarlyView.Emery et al. bring together findings from recent multi‐omic studies, including single‐cell mRNA analysis of human post‐mortem brain tissue, and proteomic analysis of matched CSF and blood samples in large clinical studies. The authors present evidence of the involvement of altered VEGF signalling in vascular and immune dysfunction and neurodegeneration
Cherelle E. G. Emery +2 more
wiley +1 more source
British Journal of Pharmacology, EarlyView.Abstract Vascular toxicity is a growing concern in cancer patients receiving vascular endothelial growth factor inhibitor (VEGFi) therapy, posing a significant threat to patient prognosis. While the primary mechanism of VEGFi‐induced vascular toxicity is linked to redox‐sensitive reactions that disrupt vascular tone, leading to hypertension and ...
Grace Whelan, Karla B. Neves
wiley +1 more source
Targeting glycolytic reprogramming by tsRNA-0032 for treating pathological lymphangiogenesis
Cell Death and DiseaseLymphangiogenesis is vital for tissue fluid homeostasis, immune function, and lipid absorption. Abnormal lymphangiogenesis has been implicated in several diseases such as cancers, inflammatory, and autoimmune diseases.
Fan Ye +7 more
doaj +1 more source
Adenosine A2a receptor promotes lymphangiogenesis and lymph node metastasis
OncoImmunology, 2019 The formation of new lymphatic vessels, or lymphangiogenesis, is a critical step of the tissue repair program. In pathological conditions involving chronic inflammation or tumorigenesis, this process is often dysregulated and can contribute to disease ...
Bertrand Allard +6 more
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CRIP1 Reshapes the Gastric Cancer Microenvironment to Facilitate Development of Lymphatic Metastasis
Advanced Science, 2023 Lymphangiogenesis in tumors provides an auxiliary route for cancer cell invasion to drainage lymph nodes, facilitating the development of lymphatic metastasis (LM).
Zhonghua Wu +9 more
doaj +1 more source
Cancer Science, EarlyView.UBE2C upregulates cellular CD147 and enhances its release into the tumor microenvironment both as soluble CD147 (sCD147) and packaged within tumor‐derived exosomes. These CD147‐bearing signals induce T‐cell exhaustion, marked by elevated CTLA‐4 expression and reduced secretion of effector cytokines (IFN‐γ, TNF‐α, TGF‐β), ultimately diminishing CD8+ T ...
Xuwei Hong +7 more
wiley +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2020 Significance Endometriosis is a highly prevalent proinflammatory disease without reliable diagnostic biomarkers and cannot be cured by nowadays’ medical treatments.
Wan-Ning Li +8 more
semanticscholar +1 more source