Results 31 to 40 of about 8,541 (196)

Highlights of the Brazilian Thoracic Association guidelines for interstitial lung diseases [PDF]

, 2012
Interstitial lung diseases (ILDs) are heterogeneous disorders, involving a large number of conditions, the approach to which continues to pose an enormous challenge for pulmonologists.
Aidé, Miguel Abidon, Algranti, Eduardo, Baldi, Bruno Guedes, Bethlem, Eduardo Pamplona, Capitani, Eduardo Mello de, Caramori, Marlova Luzzi, Carvalho, Carlos Roberto Ribeiro, Carvalho, Jozélio Freire de, Coletta, Ester Nei Aparecida Martins, Costa, André Nathan, Ferreira, Rimarcs Gomes, Jezler, Sérgio, Kairalla, Ronaldo Adib, Lima, Mariana Silva, Martinez, José Antônio Baddini, Oliveira, Rudolf Krawczenko Feitoza de, Ota-Arakaki, Jaquelina Sonoe, Pereira, Carlos Alberto de Castro, Pimenta, Suzana Pinheiro, Rocha, Marcelo Jorge Jacó, Rodrigues, Silvia Carla Sousa, Rubin, Adalberto Sperb, Santana, Alfredo Nicodemos da Cruz, Soares, Maria Raquel, Steidle, Leila John Marques   +24 more
core   +3 more sources

A Retrospective Study of Lung Transplantation in Patients With Lymphangioleiomyomatosis: Challenges and Outcomes

Frontiers in Medicine, 2021
Background: Lymphangioleiomyomatosis (LAM) is a rare systemic disease that generally leads to a progressive decline in pulmonary function. Experience, especially from the Asian population, including combined drug therapy before and after lung ...
Ji Zhang, Dong Liu, Bingqing Yue, Le Ban, Min Zhou, Hongmei Wang, Jian Lv, Bo Wu, Zhenguo Zhai, Zhenguo Zhai, Kai-Feng Xu, Wenhui Chen, Jingyu Chen, Jingyu Chen   +13 more
doaj   +1 more source

Sporadic Lymphangioleiomyomatosis Disease: A Case Report [PDF]

Iranian Journal of Medical Sciences, 2023
Pulmonary Lymphangioleiomyomatosis (LAM) is a rare disease of the lung and lymphatic system that primarily affects women of childbearing age. LAM is a progressive disease with a terrible prognosis, which worsens over time and is extremely difficult to ...
Yousef Nikmanesh, Mansoureh Shokripour, Maral Mokhtari, Mahdi Khazayi, Ahmad Monabati, Ramin Rezayi, Mehrzad Bahtouee   +6 more
doaj   +1 more source

Advanced gynecologic malignancies treated with a combination of the VEGF inhibitor bevacizumab and the mTOR inhibitor temsirolimus. [PDF]

, 2014
BackgroundBevacizumab and temsirolimus are active agents in gynecologic tumors. Temsirolimus attenuates upregulation of HIF-1α levels, a resistance mechanism for antiangiogenics, and targets the PI3-kinase/AKT/mTOR axis, commonly aberrant in these tumors.
Falchook, Gerald S, Fu, Siqing, Hong, David S, Kurzrock, Razelle, Levenback, Charles, Lu, Karen, Naing, Aung, Piha-Paul, Sarina A, Tsimberidou, Apostolia M, Wheler, Jennifer J   +9 more
core   +3 more sources

Osteoprotegerin Contributes to the Metastatic Potential of Cells with a Dysfunctional TSC2 Tumor-Suppressor Gene [PDF]

, 1974
In addition to its effects on bone metabolism, osteoprotegerin (OPG), a soluble member of the tumor necrosis factor family of receptors, promotes smooth muscle cell proliferation and migration and may act as a survival factor for tumor cells.
Steagall, Wendy K., Pacheco-Rodriguez, Gustavo, Glasgow, Connie G., Ikeda, Yoshihiko, Lin, Jing-Ping, Zheng, Gang, Moss, Joel   +6 more
core   +1 more source

Retroperitoneal Lympathic Malformations as First Presentation of Lymphangioleiomyomatosis

Journal of the Belgian Society of Radiology, 2021
Teaching Point: This case highlights the extrapulmonary lymphatic abnormalities that may be associated with pulmonary lymphangioleiomyomatosis.
Christine Lenfant, Cristina Anca Dragean
doaj   +1 more source

Cathepsin K in lymphangioleiomyomatosis: LAM cell-fibroblast Interactions enhance protease activity by extracellular acidification [PDF]

, 2017
Lymphangioleiomyomatosis (LAM) is a rare disease in which clonal ‘LAM’ cells infiltrate the lungs and lymphatics. In association with recruited fibroblasts, LAM cells form nodules adjacent to lung cysts. It is assumed LAM nodule derived proteases lead to
Akhenblit, Andrew J. Fisher, Arundhati Dongre, Atochina-Vasserman, Badri, Bee, Boonen, Bromme, Chang, Chang, Chilosi, Clements, Debbie Clements, Ferri, Finlay, Goldberg, Goncharova, Goncharova, Greenlee, Hayashi, Henske, Inoue, Johnson, Kaluz, Kang, Kant, Kneissel, Lecaille, Lee, Levy, Livak, Lou, Martignoni, Matsui, McCormack, McCormack, McDonald, McIntyre, Montgomery, Odajima, Onda, Pacchiano, Parkhitko, Pea, Punturieri, Repnik, Riihonen, Romero, Simon R. Johnson, Touisni, Turk, Yu, Zhao, Zhe   +53 more
core   +2 more sources

Histamine signaling and metabolism identify potential biomarkers and therapies for lymphangioleiomyomatosis

EMBO Molecular Medicine, 2021
Inhibition of mTOR is the standard of care for lymphangioleiomyomatosis (LAM). However, this therapy has variable tolerability and some patients show progressive decline of lung function despite treatment.
Carmen Herranz, Francesca Mateo, Alexandra Baiges, Gorka Ruiz de Garibay, Alexandra Junza, Simon R Johnson, Suzanne Miller, Nadia García, Jordi Capellades, Antonio Gómez, August Vidal, Luis Palomero, Roderic Espín, Ana I Extremera, Eline Blommaert, Eva Revilla‐López, Berta Saez, Susana Gómez‐Ollés, Julio Ancochea, Claudia Valenzuela, Tamara Alonso, Piedad Ussetti, Rosalía Laporta, Antoni Xaubet, José A Rodríguez‐Portal, Ana Montes‐Worboys, Carlos Machahua, Jaume Bordas, Javier A Menendez, Josep M Cruzado, Roser Guiteras, Christophe Bontoux, Concettina La Motta, Aleix Noguera‐Castells, Mario Mancino, Enrique Lastra, Raúl Rigo‐Bonnin, Jose C Perales, Francesc Viñals, Alvaro Lahiguera, Xiaohu Zhang, Daniel Cuadras, Coline H M van Moorsel, Joanne J van der Vis, Marian J R Quanjel, Harilaos Filippakis, Razq Hakem, Chiara Gorrini, Marc Ferrer, Aslihan Ugun‐Klusek, Ellen Billett, Elżbieta Radzikowska, Álvaro Casanova, María Molina‐Molina, Antonio Roman, Oscar Yanes, Miquel A Pujana   +56 more
doaj   +1 more source

Successful management of bilateral refractory chylothorax after double lung transplantation for lymphangioleiomyomatosis

Annals of Thoracic Medicine, 2014
Lymphangioleiomyomatosis (LAM) is a rare disease that leads to airways and lymphatic channels obstruction due to abnormal smooth muscle proliferation. It presents with dyspnea, pneumothorax or chylothorax.
Mohammed Hussein, Yasser M Aljehani, Imran Nizami, Waleed Saleh   +3 more
doaj   +1 more source

An entity that poses continuous challenge despite treatment attempt: lymphangioleiomyomatosis

The Pan African Medical Journal, 2020
In May of 2016, a 37-years-old Hispanic female, with no significant past medical history was brought to our hospital with right-sided chest pain. Chest X ray revealed large right pneumothorax (A) and she underwent chest tube placement.
Munish Sharma, Salim Surani
doaj   +1 more source