Results 61 to 70 of about 13,250 (289)
A 2-year randomised placebo-controlled trial of doxycycline for lymphangioleiomyomatosis [PDF]
, 2014 Lymphangioleiomyomatosis (LAM) is characterised by lung cysts and airflow obstruction. Matrix metalloproteinases have been implicated in lung destruction in LAM.
Cane, Jennifer L. +5 more
core +2 more sources
Single Cell Transcriptomic Analysis Identifies a Unique Pulmonary Lymphangioleiomyomatosis Cell.
American Journal of Respiratory and Critical Care Medicine, 2020 RATIONALE Lymphangioleiomyomatosis (LAM) is a metastatic neoplasm of reproductive age women associated with mutations in tuberous sclerosis complex (TSC) genes. LAM causes cystic remodeling of the lung and progressive respiratory failure. The sources and
M. Guo +17 more
semanticscholar +1 more source
Scientific Reports, 2021 There are few published data on long-term treatment with sirolimus in lymphangioleiomyomatosis (LAM). The objective of this study was to describe the long-term effect of sirolimus in a series of LAM patients followed up in a referral centre, focusing on ...
Eva Revilla-López +23 more
semanticscholar +1 more source
Recent advances in the management of lymphangioleiomyomatosis [version 1; referees: 4 approved]
F1000Research, 2018 Lymphangioleiomyomatosis is a rare disorder that predominantly affects women and is characterized by progressive cystic changes in the lung, leading to gradually worsening shortness of breath and lung function impairment.
Kai-Feng Xu, Xinlun Tian, Jay H Ryu
doaj +1 more source
Frontiers in Medicine, 2021 Background: The desaturation–distance ratio (DDR), the ratio of the desaturation area to the distance walked, is a promising, reliable, and simple physiologic tool for functional evaluation in subjects with interstitial lung diseases ...
Douglas Silva Queiroz +8 more
doaj +1 more source
Lymphangioleiomyomatosis and pregnancy: a mini-review
Archives of Gynecology and ObstetricsLymphangioleiomyomatosis(LAM) is a slow progressive, rare cystic lung disease in women of reproductive age, associated with infiltration of the lung by atypical smooth muscle like cells, leading to the cystic destruction of the lung parenchyma.
Jieshu Zhou, Min Diao
semanticscholar +1 more source
Scientific Reports, 2021 Lymphangioleiomyomatosis (LAM) is a rare destructive lung disease characterized by multiple thin-walled pulmonary cysts. The currently proposed diagnostic algorithm emphasizes the characteristic cystic appearance on high-resolution computed tomography ...
Yasuhito Sekimoto +11 more
semanticscholar +1 more source
Retroperitoneal Lympathic Malformations as First Presentation of Lymphangioleiomyomatosis
Journal of the Belgian Society of Radiology, 2021 Teaching Point: This case highlights the extrapulmonary lymphatic abnormalities that may be associated with pulmonary lymphangioleiomyomatosis.
Christine Lenfant, Cristina Anca Dragean
doaj +1 more source
Osteoprotegerin Contributes to the Metastatic Potential of Cells with a Dysfunctional TSC2 Tumor-Suppressor Gene [PDF]
, 1974 In addition to its effects on bone metabolism, osteoprotegerin (OPG), a soluble member of the tumor necrosis factor family of receptors, promotes smooth muscle cell proliferation and migration and may act as a survival factor for tumor cells.
Steagall, Wendy K. +6 more
core +1 more source
Lymphangioleiomyomatosis (LAM) [PDF]
Breathe, 2017 LAM is characterised by lung cysts (air-filled sacs which gradually destroy the lung), changes to the lymphatic system and tumours in the kidneys.
openaire +2 more sources