Results 71 to 80 of about 13,250 (289)

Cathepsin K in lymphangioleiomyomatosis: LAM cell-fibroblast Interactions enhance protease activity by extracellular acidification [PDF]

, 2017
Lymphangioleiomyomatosis (LAM) is a rare disease in which clonal ‘LAM’ cells infiltrate the lungs and lymphatics. In association with recruited fibroblasts, LAM cells form nodules adjacent to lung cysts. It is assumed LAM nodule derived proteases lead to
Akhenblit, Andrew J. Fisher, Arundhati Dongre, Atochina-Vasserman, Badri, Bee, Boonen, Bromme, Chang, Chang, Chilosi, Clements, Debbie Clements, Ferri, Finlay, Goldberg, Goncharova, Goncharova, Greenlee, Hayashi, Henske, Inoue, Johnson, Kaluz, Kang, Kant, Kneissel, Lecaille, Lee, Levy, Livak, Lou, Martignoni, Matsui, McCormack, McCormack, McDonald, McIntyre, Montgomery, Odajima, Onda, Pacchiano, Parkhitko, Pea, Punturieri, Repnik, Riihonen, Romero, Simon R. Johnson, Touisni, Turk, Yu, Zhao, Zhe   +53 more
core   +2 more sources

Microscopic precursor lesions of uterine lymphangioleiomyomatosis associated with incidental nodal lymphangioleiomyomatosis: A case report and discussion of pathogenesis

Human Pathology: Case Reports, 2020
A 47 yo woman underwent resection of an endometrial adenocarcinoma with pelvic lymph node biopsies. She was found to have incidental nodal lymphangioleiomyomatosis (LAM).
Charles M. Lombard
doaj  

Highlights of the Brazilian Thoracic Association guidelines for interstitial lung diseases [PDF]

, 2012
Interstitial lung diseases (ILDs) are heterogeneous disorders, involving a large number of conditions, the approach to which continues to pose an enormous challenge for pulmonologists.
Aidé, Miguel Abidon, Algranti, Eduardo, Baldi, Bruno Guedes, Bethlem, Eduardo Pamplona, Capitani, Eduardo Mello de, Caramori, Marlova Luzzi, Carvalho, Carlos Roberto Ribeiro, Carvalho, Jozélio Freire de, Coletta, Ester Nei Aparecida Martins, Costa, André Nathan, Ferreira, Rimarcs Gomes, Jezler, Sérgio, Kairalla, Ronaldo Adib, Lima, Mariana Silva, Martinez, José Antônio Baddini, Oliveira, Rudolf Krawczenko Feitoza de, Ota-Arakaki, Jaquelina Sonoe, Pereira, Carlos Alberto de Castro, Pimenta, Suzana Pinheiro, Rocha, Marcelo Jorge Jacó, Rodrigues, Silvia Carla Sousa, Rubin, Adalberto Sperb, Santana, Alfredo Nicodemos da Cruz, Soares, Maria Raquel, Steidle, Leila John Marques   +24 more
core   +3 more sources

Meningiomas in Lymphangioleiomyomatosis [PDF]

JAMA, 2001
Lymphangioleiomyomatosis (LAM), a cystic lung disease associated with progressive respiratory failure, is found predominantly in women of childbearing age and therefore has been treated with progesterone and other hormonal agents. However, meningiomas have progesterone receptors, and progesterone is believed to be a mitogen for meningioma cells in ...
Angelo M. Taveira-DaSilva, Rosamma DeCastro, Nicolas J. Patronas, Joel Moss   +3 more
openaire   +3 more sources

Protease activity sensors enable real-time treatment response monitoring in lymphangioleiomyomatosis

European Respiratory Journal, 2021
Background Biomarkers of disease progression and treatment response are urgently needed for patients with lymphangioleiomyomatosis (LAM). Activity-based nanosensors, an emerging biosensor class, detect dysregulated proteases in vivo and release a ...
Jesse D. Kirkpatrick, Ava P. Soleimany, Jaideep S. Dudani, Heng-Jia Liu, H. Lam, C. Priolo, E. Henske, S. Bhatia   +7 more
semanticscholar   +1 more source

Epitheloid Variant of Angiomyolipoma in a Patient with Tuberous Sclerosis. [PDF]

, 2013
Epitheloid angiomyolipoma of kidney is a type of Perivascular endothelial cell derived tumor with an aggressive behaviour with specific pathological, immunohistochemistrical and genetic characteristics.
Amirtham, U, Challa, VR, Goud, BYG, Rangappa, P, Swamyvelu, K   +4 more
core   +1 more source

Advanced gynecologic malignancies treated with a combination of the VEGF inhibitor bevacizumab and the mTOR inhibitor temsirolimus. [PDF]

, 2014
BackgroundBevacizumab and temsirolimus are active agents in gynecologic tumors. Temsirolimus attenuates upregulation of HIF-1α levels, a resistance mechanism for antiangiogenics, and targets the PI3-kinase/AKT/mTOR axis, commonly aberrant in these tumors.
Falchook, Gerald S, Fu, Siqing, Hong, David S, Kurzrock, Razelle, Levenback, Charles, Lu, Karen, Naing, Aung, Piha-Paul, Sarina A, Tsimberidou, Apostolia M, Wheler, Jennifer J   +9 more
core   +3 more sources

CrossTORC and WNTegration in Disease: Focus on Lymphangioleiomyomatosis

International Journal of Molecular Sciences, 2021
The mechanistic target of rapamycin (mTOR) and wingless-related integration site (Wnt) signal transduction networks are evolutionarily conserved mammalian growth and cellular development networks. Most cells express many of the proteins in both pathways,
Jilly F. Evans, K. Obraztsova, Susan M. Lin, V. Krymskaya   +3 more
semanticscholar   +1 more source

Maternal Sirolimus Treatment Reverses Cardiac Rhabdomyoma‐Induced Hydrops Fetalis in a Twin Gestation With Tuberous Sclerosis Complex

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Cardiac rhabdomyomas are often the presenting sign of tuberous sclerosis complex (TSC). Prior reports have shown that maternal sirolimus treatment can reduce rhabdomyomas. We used maternal sirolimus to reverse hydrops fetalis due to a massive cardiac rhabdomyoma in a twin gestation.
David M. Ritter, Kristin Schneider, Nkiru Ezeakudo, Darcy A. Krueger, Tomoyuki Mizuno, Timothy K. Knilans, David N. Franz   +6 more
wiley   +1 more source

The UK guidelines for management and surveillance of Tuberous Sclerosis Complex. [PDF]

, 2018
Background: The severity of Tuberous Sclerosis Complex (TSC) can vary among affected individuals. Complications of TSC can be life threatening, with significant impact on patients' quality of life.
Amin, S, Bolton, PF, Elmslie, F, Gale, DP, Harland, C, Johnson, SR, Kingswood, JC, O'Callaghan, FJ, Parker, A, Sampson, JR, Smeaton, M, Wright, I   +11 more
core   +3 more sources