Results 201 to 210 of about 244,685 (245)

Genetic Ablation and Multi‐Omics Profiling Reveal CEP55 as a Key Driver of Tumorigenesis in Diverse Cancer Models

Advanced Science, EarlyView.
Genetic ablation of Cep55 in Pten‐deficient mouse models delays tumorigenesis. Integrated multi‐omics analyses (proteomics, phosphoproteomics, and spatial transcriptomics) reveal that CEP55 regulates oncogenic signaling (RAS/ERK, PI3K/AKT), integrin/FAK‐mediated adhesion, extracellular matrix (ECM) remodeling, and endocytosis.
Behnam Rashidieh, Yuanhao Yang, Amanda Louise Bain, Phillip Theron, Catharina Vosloo, Sahar Keshvari, Parinaz Ahangar, Brydie Bowden, Simon M. Tria, Ben B. Wang, Sandra Isenmann, Nicholas J. Westra van Holthe, Zherui Xiong, Hani Vu, Sowmya Sharma, Asmerom Sengal, J. Alejandro Lopez, John Finnie, Antonella Papa, Pascal H.G. Duijf, Quan Nguyen, Pirjo M. Apaja, Kum Kum Khanna   +22 more
wiley   +1 more source

The role of the cardiac lymphatic system in heart failure "reverse remodeling": from developmental signals to druggable targets. [PDF]

Front Immunol
Huang T, Qi T, Yao L, Zhu Z, Li C, Tang P, Meng Z, Wen Z, Wang T, Liu S, Xie P, Li Z, Hu J.   +12 more
europepmc   +1 more source

EDNRA Forms a Positive Feedback Loop with the Hippo/YAP Axis to Drive Triple‐Negative Breast Cancer Progression

Advanced Science, EarlyView.
Endothelin receptor type A (EDNRA) and the Hippo/YAP pathway form a self‐reinforcing loop that sustains triple‐negative breast cancer. EDNRA activates YAP through Gαq/11–Rho/ROCK–LATS signaling, while YAP/TEAD4 reciprocally drives EDNRA transcription.
Zehao Hong, Boyang Li, Jiahui Xu, Ruonan Lin, Jinghao Pan, Chenlu Fang, Boxiang Zhang, Lucy Yue Lau, Richard J. Aldridge, Elizabeth A. Whitmore, Yi Chen   +10 more
wiley   +1 more source

Diagnostic value of combined computed tomography lymphangiography and technetium-99m dextran lymphoscintigraphy in systemic lupus erythematosus complicated with chylous effusion and/or lymphedema. [PDF]

Quant Imaging Med Surg
Guo L, Zhang C, Sun Y, Sun Y, Wen Z, Guo J, Yan X, Wang M, Yang L, Wang R, Yue Y.   +10 more
europepmc   +1 more source

Dual Lineages of Langerhans Cells Cooperate to Restore the Immune Barrier after Skin Injury

Advanced Science, EarlyView.
After skin injury, the epidermal immune barrier is rebuilt by two sources of Langerhans cells. Resident Langerhans cells first move into the wound during re‐epithelialization, guided by CXCR2 signaling. Later, recruited monocytes become long‐lived Langerhans cells.
Axel D. Schmitter‐Sánchez, Nicholas Basista, Sudhanshu Mishra, Hyeri Kim, Audrey Bench, Catherine Matte‐Martone, Min‐Soo Seo, Gun Woo Lee, Sangbum Park   +8 more
wiley   +1 more source

Evolution of the Caprini risk assessment score: 1991 to present: A living risk assessment tool. [PDF]

J Vasc Surg Venous Lymphat Disord
Lohr J.
europepmc   +1 more source

Multifocal lymphangioma involving the liver, spleen, and retroperitoneum: A rare adult presentation. [PDF]

Radiol Case Rep
Bagheri M, Moharrami Yeganeh P, Fakhar N, Ayoobi Yazdi N, Salahshour F.   +4 more
europepmc   +1 more source

Mechanisms and treatments of lymphedema. [PDF]

Front Immunol
Ren H, Gong Y, Zhang S, Liu J, Shen J, Gizinger O, Aripova T, Liu J.   +7 more
europepmc   +1 more source

Effects of monoglucosyl hesperidin on human lymphatic circulatory function: A randomized placebo-controlled, double-blind, crossover trial. [PDF]

Sci Rep
Shinaoka A, Honjo T, Takata K, Karasudani Y, Moriguchi S, Tanaka Y, Minami H, Maekawa T, Maeda A, Kimata Y.   +9 more
europepmc   +1 more source

VEGF-D-induced intraosseous lymphangiogenesis drives site-specific heterotopic bone resorption. [PDF]

Proc Natl Acad Sci U S A
Vishlaghi N, Griswold-Wheeler D, Korlakunta S, Vallejo A, Mittal M, Sun Y, Zhao P, Yang YP, Rutkowski JM, Levi B, Dellinger M.   +10 more
europepmc   +1 more source