Results 231 to 240 of about 199,212 (293)

Glymphatic System Dysfunction in Epilepsy: Clinical and Translational Perspectives. [PDF]

Epilepsy Curr
Lee DA, Lee HJ, Park KM.
europepmc   +1 more source

Tyrosinase Driven‐Intracellular Polymerization of a Porphyrin Derivative Induced Immunogenic Death of Melanoma Cells and Strengthened Photodynamic Therapy

Advanced Science, EarlyView.
This study uses tyrosinase, which is highly expressed in melanoma, to drive porphyrins to polymerize and self‐assemble within tumor cells to form retented microstructures. This process induces immunogenic death and activates immune responses (M1 macrophages, dendritic cells, CD8+T cells), turning “cold” tumors into “hot” tumors.
Mian Tang, Junteng Qiu, Yunfeng Lu, Yahui Song, Xinyu Zhou, Tianshun Duan, Xuanqi Peng, Caixia Yin, Cheng Gao, Ruibing Wang   +9 more
wiley   +1 more source

Physiological Implications of Pancreatic Amyloid Polypeptide Aggregation and Its Inhibition by Melatonin. [PDF]

Int J Mol Sci
Yoo YM, Joo SS.
europepmc   +1 more source

SpaMode: A Broadly Applicable Framework for Deciphering Spatial Multi‐Omics Using Multimodal Mixture of Disentangled Experts

Advanced Science, EarlyView.
SpaMode introduces a versatile framework for spatial multi‐omics integration across vertical, horizontal, and mosaic scenarios. By disentangling modality‐invariant and variant features through a mixture‐of‐experts mechanism, it adaptively reconfigures spatially heterogeneous signals.
Xubin Zheng, Xinlei Huang, Xiang Zhou, Dian Meng, Ziyue Qiao, Zhiyuan Yuan, Lixin Cheng   +6 more
wiley   +1 more source

A retrospective clinical analysis of pediatric mediastinal space-occupying lesions in a Chinese children's hospital from 2015 to 2024. [PDF]

Front Oncol
Zhao M, Song L, Zhang H, Xue N, Chen S, Guo Q.   +5 more
europepmc   +1 more source

WTAP‐Mediated m6A Modification Targets the LRP1‐Lipid Metabolism Axis to Regulate Joint Cartilage Regeneration

Advanced Science, EarlyView.
WTAP drives cartilage regeneration by activating an LRP1‐dependent lipid metabolic program in macrophages, enhancing IL‐10 and TGF‐β secretion to promote chondrogenic differentiation. Leveraging this mechanism, virtual screening identifies LRP1‐targeting compounds that effectively stimulate cartilage repair, highlighting a druggable epigenetic ...
Chenyan Huang, Chenyu Deng, Zhengrong Gao, Chen Chen, Huimin Zheng, Yue Yang, Yan Wei   +6 more
wiley   +1 more source

Enablers of Post-Validation Surveillance for Lymphatic Filariasis in the Pacific Islands: A Nominal Group Technique and Expert Elicitation. [PDF]

Trop Med Infect Dis
Craig AT, Couteaux C, Jetton K, Nehemia R, Sokana O, Tong T, Bauro T, Baratio T, Tukai O, Takai J, Viali S, Soares NG, Ome-Kaius M, Yohogu M, Volavola L, Tatui P, Taleo F, Saketa S, Tucker A, Mackenzie C, Gass K, Jian H, Lau CL, Lawford HLS.   +23 more
europepmc   +1 more source

Quantum Dots for Biomedical Biosensing, NIR‐II Bioimaging, and Phototherapy: Materials Design, Signal Transduction, and Translational Barriers

Advanced Science, EarlyView.
This review outlines bottom‐up and biomimetic fabrication strategies of quantum dots, and highlights their emerging applications in biosensing, multimodal bioimaging, and intelligent cancer theranostics. It further discusses key translational barriers and future perspectives for advancing QD‐based nanomedicine toward clinical implementation.
Jie Ju, Zhifang Liu, Xinran Gao, Wen Sun, Wei Fu, Yanfei Wang   +5 more
wiley   +1 more source

Comprehensive assessment of a hotspot with persistent bancroftian filariasis in coastal Sri Lanka [PDF]

, 2018
Dassanayaka, Tharanga D. M., Goss, Charles W, Mendis, Devika, Nagodavithana, Kumara C, Punchihewa, Manjula W, Ranasinghe, Udaya S. B., Rao, Ramakrishna U, Samarasekera, Sandhya D, Weil, Gary J   +8 more
core   +1 more source

Eosinophilic plastic bronchitis - A case report. [PDF]

Respir Med Case Rep
Chapel AC, Mandal Y, Timmons C, Wang C, Ghera P.   +4 more
europepmc   +1 more source