Results 241 to 250 of about 2,612,610 (300)

NSUN3‐Associated m5C Modification of tRF5‐GlyTCC Suppresses Colorectal Cancer Progression via RPL23‐Linked Nucleolar Stress and p53‐Associated Autophagy and Enhances 5‐FU Sensitivity

Advanced Science, EarlyView.
This study identifies that NSUN3‐mediated m5C modification stabilizes tRF5‐GlyTCC, linking ribosomal homeostasis, nucleolar stress responses, and p53 signaling changes. This regulatory axis suppresses colorectal cancer and enhances chemotherapy response to 5‐FU, positioning tRF5‐GlyTCC as a potential therapeutic target for improving drug sensitivity in
Xinhui Lv, Can Tang, Feiyang Song, Yu Wu, Yafang Chen, Sicong Liu, Ziwen Yuan, Guihua Wang, Xudong Wang   +8 more
wiley   +1 more source

GLP-1 receptor agonists and lymphedema: from weight loss to potential direct modulation of lymphatic function. [PDF]

Front Endocrinol (Lausanne)
Merzel Šabović EK, Janić M, Planinšek Ručigaj T.   +2 more
europepmc   +1 more source

Pyruvate Kinase M2‐Mediated H3K9 Lactylation and XBP1 Signaling Positive Feedback Loop Facilitates CD4+ T Cell Spinal Recruitment and Central Sensitization in Rheumatoid Arthritis

Advanced Science, EarlyView.
In collagen‐induced arthritis (CIA) mice, increased CD4+ T cell accumulation in the spinal dorsal horn induces pain hypersensitivity. Mechanistically, PKM2‐mediated H3K9 lactylation and XBP1 signaling positive feedback loop facilitates CD4+ T cell spinal migration and induces central sensitization‐like behaviors in CIA mice.
Yuepeng Jiang, Xiaoxuan Zhao, Xiao Ma, Mengjia Zheng, Junjun Wen, Yujie Li, Yue Wu, Yun Zhang, Jie Yu, Charles R. Ashby Jr, Chengping Wen   +10 more
wiley   +1 more source

Malar Edema after Hyaluronic Acid Dermal Fillers: Expert Recommendations on Etiology, Prevention, and Management. [PDF]

Dermatol Ther (Heidelb)
Baranska-Rybak W, Lajo-Plaza JV, Walker L, Alizadeh N.   +3 more
europepmc   +1 more source

An Explainable Multimodal Deep‐Learning Model Using Histopathological Image and Clinical Information for Prognosis Prediction in Colorectal Cancer: A Multi‐Center Cohort Study

Advanced Science, EarlyView.
This study develops a multimodal deep‐learning model that integrates clinical variables and histopathological images to predict survival outcomes in colorectal cancer. The multimodal model effectively stratifies patients into low‐ and high‐risk groups, demonstrating superior accuracy and generalizability across multiple independent cohorts.
Zhihan Jiang, Xiangchao Shi, Chenghan Su, Yao Ma, Rui Li, Menglei Chen, Jianxin Cui, Nicholas Hawkins, Robyn Ward, Xiangzhi Bai, Jitendra Jonnagaddala, Wei Fu, Xin Zhou   +12 more
wiley   +1 more source

Breakdown of adipocyte-endothelial communication as a driver of adipose tissue dysfunction in obesity. [PDF]

Front Endocrinol (Lausanne)
Chaurasiya V, Pham DD, Olkkonen VM.
europepmc   +1 more source

Biomimetic Nanoplatform for Fibrosis Remodeling and Anti‐PD‐1 Potentiation via Cu+/Ca2+ Ion Dysregulation and TGF‐β Inhibition in PDAC

Advanced Science, EarlyView.
A biomimetic nanoplatform (RPm@CC‐LY) remodels fibrotic stroma via sustained TGF‐β inhibition, triggers oxidative stress and apoptosis through Cu+‐mediated Fenton chemistry and Ca2+ overload, and reprograms macrophages and dendritic cells to boost CD8+ T cell infiltration.
Jianmei Li, Qinlong Wen, Jie Dai, Li Yang, Feng Xiong, Zhigong Wei, Xingchen Peng   +6 more
wiley   +1 more source

<i>Fusobacterium</i><i>nucleatum</i>-Stimulated OSCC Cell-Derived Exosomes Induce a Pro-Adhesive Phenotype in Lymphatic Endothelial Cells <i>via</i> the ROS/NF-κB/ICAM1 Axis. [PDF]

Microorganisms
Wei L, He Q, Gao H, Li W, Sun T, Feng Q.
europepmc   +1 more source

RAS-PI3Kα signaling regulates KrasG12D-induced lymphangiogenesis in complex lymphatic anomalies. [PDF]

Dis Model Mech
Fernandes LM, Tresemer J, Vallejo A, Yao A, Scallan JP, Dellinger MT.   +5 more
europepmc   +1 more source